User:Tkadm30/Notebook/Paliperidone/2013/10/10: Difference between revisions
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(New page: == 9-OH (risperidone) degradation scrachpad== * Todo: # Investigate CYP2D6 # Establish Role of [http://www.uniprot.org/uniprot/Q06278 Aldehyde oxidase] in paliperidone metabolite degrad...) |
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== 9-hydroxyrisperidone degradation and racemization == | |||
# | |||
# Establish | === From PLP substrate: The road to PMP === | ||
# | |||
#Goal: Transamination of 9-OH to inactivated PLP racemase | |||
#Method: Racemization of optically-active metabolite to produce pyridoxal phosphate as a Schiff base/intermediate to PMP. | |||
#Notebooks: | |||
## [[User:Etienne_Robillard/Notebook/Paliperidone/2013/06/21|Part 1: PLP biosynthesis from 9-hydroxyrisperidone metabolite]] | |||
# CYP2D6: Metabolite degradation, liver enzymes (NADPH?), | |||
## http://dmd.aspetjournals.org/content/29/10/1263.full | |||
## Establish role of [http://www.uniprot.org/uniprot/Q06278 Aldehyde oxidase] in paliperidone metabolite degradation | |||
# ATP hydrolysis: | |||
## Enzyme assisted metabolite racemization (serine racemase): [http://www.uniprot.org/uniprot/Q9GZT4 Uniprot] | |||
### Note: "Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP. Competitively inhibited by malonate.") | |||
#keywords: TCA | |||
==See also== | |||
[[User:Etienne_Robillard/Notebook/OPH|OPH Notebook]] |
Revision as of 06:15, 6 December 2013
9-hydroxyrisperidone degradation and racemization
From PLP substrate: The road to PMP
- Goal: Transamination of 9-OH to inactivated PLP racemase
- Method: Racemization of optically-active metabolite to produce pyridoxal phosphate as a Schiff base/intermediate to PMP.
- Notebooks:
- CYP2D6: Metabolite degradation, liver enzymes (NADPH?),
- http://dmd.aspetjournals.org/content/29/10/1263.full
- Establish role of Aldehyde oxidase in paliperidone metabolite degradation
- ATP hydrolysis:
- Enzyme assisted metabolite racemization (serine racemase): Uniprot
- Note: "Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP. Competitively inhibited by malonate.")
- Enzyme assisted metabolite racemization (serine racemase): Uniprot
- keywords: TCA