User:Etienne Robillard/Notebook/Paliperidone/2013/10/10

From OpenWetWare

< User:Etienne Robillard | Notebook | Paliperidone(Difference between revisions)
Jump to: navigation, search
Current revision (09:15, 6 December 2013) (view source)
(From PLP substrate: The road to PMP)
 
Line 8: Line 8:
#Method: Racemization of optically-active metabolite to produce pyridoxal phosphate as a Schiff base/intermediate to PMP.
#Method: Racemization of optically-active metabolite to produce pyridoxal phosphate as a Schiff base/intermediate to PMP.
#Notebooks:
#Notebooks:
-
## [[User:Etienne_Robillard/Notebook/Paliperidone/2013/06/21|Part 1: PLP biosynthesis from 9-hydroxyrisperidone]]
+
## [[User:Etienne_Robillard/Notebook/Paliperidone/2013/06/21|Part 1: PLP biosynthesis from 9-hydroxyrisperidone metabolite]]
# CYP2D6: Metabolite degradation, liver enzymes (NADPH?),  
# CYP2D6: Metabolite degradation, liver enzymes (NADPH?),  
## http://dmd.aspetjournals.org/content/29/10/1263.full
## http://dmd.aspetjournals.org/content/29/10/1263.full

Current revision

Contents


9-hydroxyrisperidone degradation and racemization

From PLP substrate: The road to PMP

  1. Goal: Transamination of 9-OH to inactivated PLP racemase
  2. Method: Racemization of optically-active metabolite to produce pyridoxal phosphate as a Schiff base/intermediate to PMP.
  3. Notebooks:
    1. Part 1: PLP biosynthesis from 9-hydroxyrisperidone metabolite
  4. CYP2D6: Metabolite degradation, liver enzymes (NADPH?),
    1. http://dmd.aspetjournals.org/content/29/10/1263.full
    2. Establish role of Aldehyde oxidase in paliperidone metabolite degradation
  5. ATP hydrolysis:
    1. Enzyme assisted metabolite racemization (serine racemase): Uniprot
      1. Note: "Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP. Competitively inhibited by malonate.")
  6. keywords: TCA

See also

OPH Notebook

Personal tools