User:Etienne Robillard/Notebook/Piperidine

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  • An important secondary amine used as precursor to alkylamines with a aryl-ketone (heteroarylalkyl) moeity when the reaction is performed in presence of a [cyanide anion] as the nitrogen substitution group .
  • In organic synthesis, piperidine may participate in hydrogenation of C=N double bounds where the N-substituted chiral imine center may be converted to a enamine, the tautomeric form of a imine. 1

Reductive alkylation of N-aryl substituted imines via piperidine-derived enamines

Piperidine derivatives in nucleophilic keto-enol (imine) substitutions

  • For DNA depurination with a 2-cyanoethyl hetero-aryl-alkyl moeity (ie: a N-methyl cyanide anion), see Ethanamine
  • For in situ polymer-based drug delivery of phenethylamine substituted imines, see Phenethylamine and Grignard reagents .

See also

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