User:Tkadm30/Notebook/Research

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Research interests

• Aluminium-induced oxidative stress and chronic neuroinflammation of the CNS
  • Gulf war syndrome
• Glutamatergic system/neurotransmission
  • Glutamate-induced NMDA excitotoxicity
  • Glutaminase
• Astrocytes/mitochondria interactions
  • Glutamatergic CB1 expression in hippocampal astrocytes and mitochondria
• Astrocytes/microglia interactions
  • Astrocytes-mediated neuroprotection (Traumatic brain injury)
  • Astroglia
  • Astrocyte-neuron lactate
• Intracellular DHA delivery to corticostriatal neurons
  • Corticostriatal synaptic plasticity and connectivity
• Neuroprotective effects of PPAR-gamma agonists
• Extracellular ATP releases (ATP-mediated gliotransmission)
• Effects of adenosine antagonists on retrograde synaptic activity (caffeine)
• Neuroprotection by endocannabinoids of the limbic system
  • Adult hippocampal neurogenesis regulation by CB1 receptor
  • Endocannabinoid-mediated neuroprotection against synthetic neurotoxicants of the CNS
• Intrinsic brain activity modulation by atypical antipsychotics
  • Antipsychotic-induced parkinsonism/schizophrenia (neuronal injury)
  • Antipsychotic-induced dopamine alterations (ex vivo)
    • Iatrogenic dopamine supersensitivity
  • Antipsychotic-induced hyperprolactinemia (HPRL)
  • Antipsychotic-induced oxidative stress
• Interneuronal quantum coherence in microtubules
  • Quantum entanglement of biophotons and tubulins (superradiance)
  • Orch OR theory of consciousness
• Neuronal migration, morphogenesis and maturation
• Synaptogenesis
  • Endocannabinoid-mediated synaptogenesis
• Monoamine oxidase inhibitors
  • Monoaminergic neurotransmission
• Synaptic quantum tunnelling
  • Neural synchronicity and communication in the gamma range
• Supramolecular properties of water in biological systems
  • Vibrational spectrum of biological water resonance
• Neuronal hypercomputation
  • Neuronal phase coherence
• Long-term memory formation
• Vitamin D gene expression
  • Vitamin D binding protein
  • Vitamin D receptor (VDR)
• Fatty acid binding proteins
• Self-organized criticality (SOC) in microtubules dynamics
• Biological utilization of quantum nonlocality
• Neurexins/neuroligins modulation of endocannabinoid signaling
• Chronic obstructive pulmonary disease (COPD)
  • Accumulative effects of fine particulate matter (PM2.5) exposure on AECOPD
• On-demand regulation of homeostatic synaptic plasticity by endocannabinoids
• Phase-transition-driven synaptic exocytosis and glutamatergic neurotransmission
  • Synaptic phase transitions
  • Voltage-gated calcium channels (VGCC)
• Reactive microgliosis
  • Microglial internalization
• Endocannabinoid-mediated retrograde signaling
• Neuroendocrine system
  • Neurogenesis-mediated serotonergic modulation of stress hormones
• PM2.5-mediated nanoparticle translocation and internalization
• Arachidonic acid signaling
• Quantum cognition
  • Artificial telepathy (Mind reading)
  • Brain-to-brain quantum connectivity
  • Psychocollective consciousness
  • Neuropolitics
• Fos-like immunoreactivity (FLI)
• Bioelectromagnetism
• Experimental parapsychology
  • Psychedelic research
• Calmodulin-mediated dopaminergic neuromodulation of cognitive memory
• The radicalisation of science and geoengineering
• Presynaptic dopamine/calcium signaling and homeostasis
• Extrasynaptic dopamine/glutamate exocytosis
• Biological entanglement of optical communication channels in the brain
• AKT1/GSK3 signaling
• Purinergic P2X7 receptor
• Caffeine pharmacodynamics
  • Caffeine-induced diuresis
  • Effects of caffeine on executive function
• Condensation (monodisperse) aerosols
• Phenomenology of consciousness/free will
• MicroRNA (miRNA)
  • PM2.5-mediated TLR signaling and alteration of miRNA expression
• Social neuroscience
  • The neuroscience of empathy
  • Hyperscanning
  • Mentalization
• Mirror neurons
• Limbic resonance
• Autoimmune limbic encephalitis (LE)
• Atypical psychosis
• Organic retrograde amnesia (RA)
• Dissociative amnesia
• Remote memory
• Cognitive flexibility
  • Executive function
• Fatty acid amide hydrolase (FAAH)
  • Anandamide/CYP2D6 metabolic pharmacokinetics
  • Mecanism-based inactivation of cytochrome P450 isoforms
• Psychocomputational energetics
• Atherosclerosis management and prevention
  • Protective effect of garlic on atherosclerosis
• Synaptic latency
  • Presynaptic action potential
• Phospholipase C (PLC)
• Neural transmission asynchrony
• Neurotelemetry
  • Transparent EEG acquisition
  • Frontal EEG asymmetry
• Wnt signaling
• Biophotons
  • Biophotonic quantum beats (coherent energy transfer) in microtubules
• Oxytocin
  • Oxytocin/vitamin D/anandamide signal transduction
  • Oxytocin trafficking
• Cyberhomophobia
• Distant healing
  • The healing power of plants (Biophilia)
• Quantum biology
  • Quantum coherence in photosynthesis
• Aripiprazole pharmacodynamics
  • Effects of prolonged, low-dose aripiprazole on the cardiovascular system
  • Aripiprazole functional dopaminergic psychoactivity (pharmacokinetics)
• Aerosol radiative forcing
• Lipid rafts
• Neuroholography
• Cardioprotection
  • Effects of acetic acid on the cardiovascular system
  • Effects of garlic on the cardiovascular system
• Neuropsychology of dancing
• DNA methylation
  • DNA methyltransferase inhibitors
• Mind-wandering
  • Cannabinoids for racing thoughts
  • Hyperdreaming
  • Task-negative network
• Cognitive neuronarratology
• Functionalized gold nanoparticles
• Clinical relevance of melatonin
  • Cannabinoid-induced attenuation of melatonin synthesis
  • Dopamine/melatonin interactions
• Participation of endocannabinoid mobilization in REM sleep
• Atomic singularity of human consciousness
• Plant protoconsciousness
• Oneirology
  • Psychological lucidity
• RNA-guided dopamine neurotransmission
  • Dopamine transcription factors (Nurr1, Notch1)
• Eicosanoids and docosanoids lipidomics
• THCA decarboxylation
• Neurodiversity
• Metabolic homeostasis
• Synaptogenic endocannabinoids
  • Arachidonoyl serotonin (AA-5-HT)
  • Docosahexaenoyl serotonin (DHA-5-HT)
  • N-docosahexaenoylethanolamine (DHEA)
  • N-docosahexaenoyl dopamine (DHDA)
• Tubulin heterodimerization
• Slow wave sleep (SWS) dreaming
• Phosphatidylcholine curcumin (Meriva)
• Axon guidance
• Novel opioid receptor antagonists
• Subcellular neuronal quasicrystals
• Effects of nicotine addiction on psychomotor performance
• Ionospheric heating
  • Directed ULF/VLF signal propagation in the lower ionosphere
• Clinical pharmacodynamics of endocannabinoid-based signaling
• Novel ACE inhibitors
  • ACE-inhibitory activity of probiotic yogurt
• Caffeine potentiation of cannabinoids transmission
• THC-mediated RNA interference
• Human magnetoreception
  • Allocentric spatial memory
• Deep programming
• Isoflavones
  • Red clover-derived isoflavone supplementation
• Drug-induced REM sleep disorders
• Psychosomatic disorders
• Nicotinic facilitation of long-term memory
• Remote ultrasonic neuromodulation of the central nervous system
• Shared neural pathways in opioid addiction and Alzheimer disease
• Cognitive neuroimmunity
• Human neurosecurity
  • Neuroprivacy
  • Neurosurveillance

Endocannabinoid research

The neurocomputational aspects of endocannabinoid-based neuroprotection has emerged as a mature research area. My current research aim to investigate experimental methods for exploiting the endocannabinoid levels for neuroprotection purpose. In particular, the study of retrograde signaling (anandamide trafficking) can be helpful to understand how on-demand anandamide mobilization fine-tune dopamine receptors availability, density, and connectivity in the PFC, striatum, and microglia.

Furthermore, the study of endocannabinoid-mediated synaptic hypercomputation is under investigation. In specific, the role and mecanism of intracellular CB1 activation in the regulation of synchronized gamma-band oscillations (neuronal phase coherence?) by dopamine is poorly documented.

Retrograde signaling dynamics

Notebook:

• Endocannabinoids Notebook
• Synopsis

Research subtopics:

• Eicosanoids synthesis
• Microglial/dopamine neuroprotection

Synaptogenic effects of DHA-5-HT, a putative endocannabinoid transporter

Notebook:

• DHA Notebook

Research subtopics:

• DHA-5-HT signaling
  • Intracellular signal transduction pathways of synaptamide
  • P2X7 receptor pharmacodynamics

See also:

• Modulation of excitatory neurotransmission by neuronal/glial signalling molecules: interplay between purinergic and glutamatergic systems

Neuroprotective effects of cannabinoids for traumatic brain injury and drug-induced neuronal damage

Intracellular CB1 activation by cannabinoids (THC) may mediate monoaminergic cross-talk and GPCR receptor heteromization, a potential neuroprotective mecanism for drug-induced neuronal damage.

• THC Notebook
• THCV Notebook

On-demand programming of neural stem cells by anandamide trafficking

Anandamide trafficking may activate AKT1/CREB signaling (phosphorylation) in the brain.

• Anandamide Notebook

Anandamide/AKT signaling

• AKT1 Notebook
• Review: The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt.

Anandamide/Oxytocin signaling

• Oxytocin Notebook
• Cannabis for erectile dysfunction?

Hypercomputation in living organisms

I aim to understand how biological hypercomputation evolved in living organisms.

• Hypercomputation Notebook

Computational domains of synaptic dopamine exocytosis

Quantum-like computational domains in dopaminergic neurons:

• Synaptic exocytosis Notebook

Psychocomputational energetics

• Psychoenergetics Notebook

RNA-guided dopamine neurotransmission and gene expression

The study of RNA-guided dopamine neurotransmission require further research to understand how transcriptional genes (Nurr1, Notch1) influence computational dopamine expression and modulation in vivo.

• Dopamine Notebook
• MicroRNA Notebook

Solar geoengineering research

Clandestine (solar) geoengineering activity is a source of air pollution and fine particulate matter, a major health and environmental issue.

• Notebook
• Research Notebook

See also

• Brainstorming

Food for thoughts

The only thing necessary for the triumph of evil is for good men to do nothing. -Edmund Burke