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'''This page has moved [https://www.isotoperesearch.ca/wiki/User:Tkadm30/Research here]. This page is less frequently updated!'''
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== Research Interests ==
== Research interests ==




Line 6: Line 8:
** Gulf war syndrome
** Gulf war syndrome
* Glutamatergic system/neurotransmission
* Glutamatergic system/neurotransmission
** Glutamate-induced excitotoxicity
** Glutamate-induced NMDA excitotoxicity
** Glutaminase
** Glutaminase
* Astrocytes/mitochondria
* Astrocytes/mitochondria interactions
** CB1 expression in hippocampal astrocytes and mitochondria
** Glutamatergic CB1 expression in hippocampal astrocytes and mitochondria
* Astrocytes/microglia
* Astrocytes/microglia interactions
** astrocytes-mediated neuroprotection
** Astrocytes-mediated neuroprotection (Traumatic brain injury)
** astroglia
** Astroglia
* Intracellular DHA delivery to striatal neurons
** Astrocyte-neuron lactate 
* Intracellular DHA delivery to corticostriatal neurons
** Corticostriatal synaptic plasticity and connectivity
* Neuroprotective effects of PPAR-gamma agonists  
* Neuroprotective effects of PPAR-gamma agonists  
** Extracellular ATP releases/ATP-mediated gliotransmission
* Extracellular ATP releases (ATP-mediated gliotransmission)
** Effects of adenosine antagonism on retrograde synaptic activity
* Effects of adenosine antagonists on retrograde synaptic activity (caffeine)
* Neuroprotection by endocannabinoids of the hippocampus
* Neuroprotection by endocannabinoids of the limbic system
** Adult hippocampal neurogenesis regulation by CB1 receptor
** Adult hippocampal neurogenesis regulation by CB1 receptor
** Endocannabinoid-mediated neuroprotection against synthetic neurotoxicants of the CNS
** Endocannabinoid-mediated neuroprotection against synthetic neurotoxicants of the CNS
* Intrinsic brain activity modulation by atypical antipsychotics
* Intrinsic brain activity modulation by atypical antipsychotics
** Drug-induced parkinsonism/schizophrenia (neuronal injury)
** Antipsychotic-induced parkinsonism/schizophrenia (neuronal injury)
** Antipsychotic-induced dopamine hypersensitivity
** Antipsychotic-induced dopamine alterations (ex vivo)
* Interneuronal quantum coherence in microtubules: Implications for quantum processing of consciousness and free will
*** Iatrogenic dopamine supersensitivity
** Orch OR theory of consciousness
** Antipsychotic-induced hyperprolactinemia (HPRL)
** Neuronal morphogenesis and maturation
** Antipsychotic-induced oxidative stress
** Synaptogenesis
* Interneuronal quantum coherence in microtubules
** Quantum entanglement of biophotons and tubulins (superradiance)
** Orch OR theory of consciousness
* Neuronal migration, morphogenesis and maturation
* Synaptogenesis
** Endocannabinoid-mediated synaptogenesis
* Monoamine oxidase inhibitors
* Monoamine oxidase inhibitors
** Monoaminergic neurotransmission
** Monoaminergic neurotransmission
* Synaptic quantum tunnelling
* Synaptic quantum tunnelling
** Neural synchronicity and communication in the gamma range
* Supramolecular properties of water in biological systems
* Supramolecular properties of water in biological systems
** Vibrational spectrum of biological water activity
** Vibrational spectrum of biological water resonance
* Biological hypercomputation
* Neuronal hypercomputation
** Neuronal phase coherence of synaptic hypercomputation
** Neuronal phase coherence  
* Long-term memory formation
* Long-term memory formation
* Vitamin D binding protein
* Vitamin D gene expression
** Vitamin D binding protein
** Vitamin D receptor (VDR)
* Fatty acid binding proteins
* Fatty acid binding proteins
* Self-organized criticality (SOC) in microtubules dynamics
* Self-organized criticality (SOC) in microtubules dynamics
Line 41: Line 53:
* Neurexins/neuroligins modulation of endocannabinoid signaling
* Neurexins/neuroligins modulation of endocannabinoid signaling
* Chronic obstructive pulmonary disease (COPD)
* Chronic obstructive pulmonary disease (COPD)
** Accumulative effects of metal oxide nanoparticles exposure on AECOPD.
** Accumulative effects of fine particulate matter (PM2.5) exposure on AECOPD
* Regulation of homeostatic synaptic plasticity by endocannabinoids
* On-demand regulation of homeostatic synaptic plasticity by endocannabinoids
* Phase-transition-driven synaptic exocytosis and neurotransmission
* Phase-transition-driven synaptic exocytosis and glutamatergic neurotransmission
** Synaptic phase transition
** Synaptic phase transitions
** Voltage-gated calcium channels (VGCC)
* Reactive microgliosis
* Reactive microgliosis
** microglial internalization
** Microglial internalization
* Endogenous retrograde signaling
* Endocannabinoid-mediated retrograde signaling
* Neuroendocrine responses
* Neuroendocrine system
** PM2.5 translocation and internalization (microglia)
** Neurogenesis-mediated serotonergic modulation of stress hormones
* Arachidonic acid
* PM2.5-mediated nanoparticle translocation and internalization  
* Arachidonic acid signaling
* Quantum cognition
* Quantum cognition
** Artificial telepathy
** Artificial telepathy (Mind reading)
** Corticostriatal connectivity
** Brain-to-brain quantum connectivity
** Psychocollective consciousness
** Neuropolitics
* Fos-like immunoreactivity (FLI)
* Fos-like immunoreactivity (FLI)
* Bioelectromagnetism
* Bioelectromagnetism
* Experimental parapsychology
* Experimental parapsychology
* Neural synchronicity
** Psychedelic research
** Calmodulin-mediated dopaminergic neuromodulation of musical memory
* Calmodulin-mediated dopaminergic neuromodulation of cognitive memory
* The radicalisation of science and geoengineering
* The radicalisation of science and geoengineering
* Calcium signaling and homeostasis
* Presynaptic dopamine/calcium signaling and homeostasis
* Extrasynaptic dopamine exocytosis
* Extrasynaptic dopamine/glutamate exocytosis
* Biological entanglement of neural communication
* Biological entanglement of optical communication channels in the brain
* AKT1/GSK3 signaling
* Purinergic P2X7 receptor
* Caffeine pharmacodynamics
** Caffeine-induced diuresis
** Effects of caffeine on executive function
* Condensation (monodisperse) aerosols
* Phenomenology of consciousness/free will
* MicroRNA (miRNA)
** PM2.5-mediated TLR signaling and alteration of miRNA expression
* Social neuroscience
** The neuroscience of empathy
** Hyperscanning
** Mentalization
* Mirror neurons
* Limbic resonance
* Autoimmune limbic encephalitis (LE)
* Atypical psychosis
* Organic retrograde amnesia (RA)
* Dissociative amnesia
* Remote memory
* Cognitive flexibility
** Executive function
* Fatty acid amide hydrolase (FAAH)
** Anandamide/CYP2D6 metabolic pharmacokinetics
** Mecanism-based inactivation of cytochrome P450 isoforms
* Psychocomputational energetics
* Atherosclerosis management and prevention
** Protective effect of garlic on atherosclerosis
* Synaptic latency
** Presynaptic action potential
* Phospholipase C (PLC)
* Neural transmission asynchrony
* Neurotelemetry
** Transparent EEG acquisition
** Frontal EEG asymmetry
* Wnt signaling
* Biophotons
** Biophotonic quantum beats (coherent energy transfer) in microtubules
* Oxytocin
** Oxytocin/vitamin D/anandamide signal transduction
** Oxytocin trafficking
* Cyberhomophobia
* Distant healing
** The healing power of plants (Biophilia)
* Quantum biology
** Quantum coherence in photosynthesis
* Aripiprazole pharmacodynamics
** Effects of prolonged, low-dose aripiprazole on the cardiovascular system
** Aripiprazole functional dopaminergic psychoactivity (pharmacokinetics)
* Aerosol radiative forcing
* Lipid rafts
* Neuroholography
* Cardioprotection
** Effects of acetic acid on the cardiovascular system
** Effects of garlic on the cardiovascular system
* Neuropsychology of dancing
* DNA methylation
** DNA methyltransferase inhibitors
* Mind-wandering
** Cannabinoids for racing thoughts
** Hyperdreaming
** Task-negative network
* Cognitive neuronarratology
* Functionalized gold nanoparticles
* Clinical relevance of melatonin
** Cannabinoid-induced attenuation of melatonin synthesis
** Dopamine/melatonin interactions
* Participation of endocannabinoid mobilization in REM sleep
* Atomic singularity of human consciousness
* Plant protoconsciousness
* Oneirology
** Psychological lucidity
* RNA-guided dopamine neurotransmission
** Dopamine transcription factors (Nurr1, Notch1)
* Eicosanoids and docosanoids lipidomics
* THCA decarboxylation
* Neurodiversity
* Metabolic homeostasis
* Synaptogenic endocannabinoids
** Arachidonoyl serotonin (AA-5-HT)
** Docosahexaenoyl serotonin (DHA-5-HT)
** N-docosahexaenoylethanolamine (DHEA)
** N-docosahexaenoyl dopamine (DHDA)
* Tubulin heterodimerization
* Slow wave sleep (SWS) dreaming
* Phosphatidylcholine curcumin (Meriva)
* Axon guidance
* Novel opioid receptor antagonists
* Subcellular neuronal quasicrystals
* Effects of nicotine addiction on psychomotor performance
* Ionospheric heating
** Directed ULF/VLF signal propagation in the lower ionosphere
* Clinical pharmacodynamics of endocannabinoid-based signaling
* Novel ACE inhibitors
** ACE-inhibitory activity of probiotic yogurt
* Caffeine potentiation of cannabinoids transmission
* THC-mediated RNA interference
* Human magnetoreception
** Allocentric spatial memory
* Deep programming
* Isoflavones
** Red clover-derived isoflavone supplementation
* Drug-induced REM sleep disorders
* Psychosomatic disorders
* Nicotinic facilitation of long-term memory
* Remote ultrasonic neuromodulation of the central nervous system
* Shared neural pathways in opioid addiction and Alzheimer disease
* Cognitive neuroimmunity
* Human neurosecurity
** Neuroprivacy
** Neurosurveillance


== Retrograde signaling as a novel neuroprotection model ==
== Endocannabinoid research ==
The neuropsychological aspects of endocannabinoid based neuroprotection has emerged as
The neurocomputational aspects of endocannabinoid-based neuroprotection has emerged as
a mature research area. My current research aim to investigate methods for exploiting
a mature research area. My current research aim to investigate experimental methods for exploiting
the endocannabinoid levels for neuroprotection purpose. In particular, the study of retrograde  
the endocannabinoid levels for neuroprotection purpose. In particular, the study of retrograde  
signaling can be helpful to understand how endocannabinoid signaling fine-tune dopaminergic receptors availability
signaling (anandamide trafficking) can be helpful to understand how on-demand anandamide mobilization
and synaptic connectivity.
fine-tune dopamine receptors availability, density, and connectivity in the PFC, striatum, and microglia.
 
Furthermore, the study of endocannabinoid-mediated synaptic hypercomputation is under investigation.
In specific, the role and mecanism of intracellular CB1 activation in the regulation of synchronized gamma-band
oscillations (neuronal phase coherence?) by dopamine is poorly documented.  
 
=== Retrograde signaling dynamics ===
Notebook:
* [[User:Tkadm30/Notebook/Endocannabinoids|Endocannabinoids Notebook]]
* [[User:Tkadm30/Notebook/Endocannabinoids/Synopsis|Synopsis]]
Research subtopics:
* Eicosanoids synthesis
* '''Microglial/dopamine neuroprotection'''


===Synaptogenic effects of DHA-5-HT, a putative endocannabinoid transporter===
Notebook:
* [[User:Tkadm30/Notebook/DHA|DHA Notebook]]
Research subtopics:
* DHA-5-HT signaling
** Intracellular signal transduction pathways of synaptamide
** P2X7 receptor pharmacodynamics
See also:
* [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749532/ Modulation of excitatory neurotransmission by neuronal/glial signalling molecules: interplay between purinergic and glutamatergic systems]


=== Intracellular delivery of synaptamide to neurons by endocannabinoids ===
===Neuroprotective effects of cannabinoids for traumatic brain injury and drug-induced neuronal damage===
This notebook propose a experimental method for intracellular delivery of synaptamide (DHA) to glutamatergic neurons using anandamide trafficking.
Intracellular CB1 activation by cannabinoids (THC) may mediate monoaminergic cross-talk and GPCR receptor
* [[User:Etienne_Robillard/Notebook/Endocannabinoids|Endocannabinoids Notebook]]
heteromization, a potential neuroprotective mecanism for drug-induced neuronal damage.
* [[User:Tkadm30/Notebook/THC|THC Notebook]]
* [[User:Tkadm30/Notebook/THCV|THCV Notebook]]


===Purinergic effects of DHA on neurotransmission, a putative endocannabinoid induced by P2X7 agonists===
===On-demand programming of neural stem cells by anandamide trafficking===
P2X7 receptor mediate synaptogenic DHA signaling and intracellular signal transduction pathways
Anandamide trafficking may activate AKT1/CREB signaling (phosphorylation) in the brain.
relevant to PPAR-induced neural differentiation. Hence, intracellular THC delivery may induce PPAR-dependent
* [[User:Tkadm30/Notebook/Anandamide|Anandamide Notebook]]
activity for DHA-mediated neural differentiation and proliferation of hippocampal progenitor cells through
====Anandamide/AKT signaling====
modulation of P2X7 receptor.
* [[User:Tkadm30/Notebook/AKT1|AKT1 Notebook]]
* [[User:Etienne_Robillard/Notebook/DHA|DHA Notebook]]
* Review: [https://www.ncbi.nlm.nih.gov/pubmed/10749665 The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt.]
===Neuroprotective effects of cannabinoids after traumatic brain injury and drug-induced neuronal damage===
* [[User:Etienne_Robillard/Notebook/THC|THC Notebook]]
* [[User:Etienne_Robillard/Notebook/THCV|THCV Notebook]]


===Programming of hippocampal progenitor cells by anandamide trafficking===
====Anandamide/Oxytocin signaling====
* [[User:Etienne_Robillard/Notebook/Anandamide|Anandamide Notebook]]
* [[User:Tkadm30/Notebook/Oxytocin|Oxytocin Notebook]]
* [https://www.mrnice.nl/forum/9-patients-forum/16287-cannabis-erectile-dysfunction.html Cannabis for erectile dysfunction?]


==Hypercomputation in living organisms==
==Hypercomputation in living organisms==
I aim to understand how biological hypercomputation evolved in living organisms.  
I aim to understand how biological hypercomputation evolved in living organisms.  
* [[User:Etienne_Robillard/Notebook/Hypercomputation|Hypercomputation Notebook]]
* [[User:Tkadm30/Notebook/Hypercomputation|Hypercomputation Notebook]]
* [[User:Etienne_Robillard/Notebook/Synaptic_exocytosis|Synaptic exocytosis Notebook]]
===Computational domains of synaptic dopamine exocytosis===
Quantum-like computational domains in dopaminergic neurons:
* [[User:Tkadm30/Notebook/Synaptic_exocytosis|Synaptic exocytosis Notebook]]
===Psychocomputational energetics===
* [https://www.isotoperesearch.ca/wiki/Psychoenergetics Psychoenergetics Notebook]
 
===RNA-guided dopamine neurotransmission and gene expression===
The study of RNA-guided dopamine neurotransmission require further research to understand
how transcriptional genes (Nurr1, Notch1) influence computational dopamine expression and modulation in vivo.
* [[User:Tkadm30/Notebook/Dopamine|Dopamine Notebook]]
* [[User:Tkadm30/Notebook/miRNA|MicroRNA Notebook]]
 
==Solar geoengineering research==
Clandestine (solar) geoengineering activity is a source of air pollution and fine particulate matter,
a major health and environmental issue.
* [[User:Tkadm30/Notebook/chim_trills_notebook|Notebook]]
* [[User:Tkadm30/Notebook/chim_trills_notebook/Research|Research Notebook]]
 
==See also==
==See also==
* [[User:Etienne_Robillard/Notebook/Brainstorming|Brainstorming]]
* [[User:Tkadm30/Notebook/Brainstorming|Brainstorming]]
 
==Food for thoughts==
<blockquote>
The only thing necessary for the triumph of evil is for good men to do nothing. -Edmund Burke
</blockquote>

Latest revision as of 03:40, 9 February 2019

This page has moved here. This page is less frequently updated!

Research interests

  • Aluminium-induced oxidative stress and chronic neuroinflammation of the CNS
    • Gulf war syndrome
  • Glutamatergic system/neurotransmission
    • Glutamate-induced NMDA excitotoxicity
    • Glutaminase
  • Astrocytes/mitochondria interactions
    • Glutamatergic CB1 expression in hippocampal astrocytes and mitochondria
  • Astrocytes/microglia interactions
    • Astrocytes-mediated neuroprotection (Traumatic brain injury)
    • Astroglia
    • Astrocyte-neuron lactate
  • Intracellular DHA delivery to corticostriatal neurons
    • Corticostriatal synaptic plasticity and connectivity
  • Neuroprotective effects of PPAR-gamma agonists
  • Extracellular ATP releases (ATP-mediated gliotransmission)
  • Effects of adenosine antagonists on retrograde synaptic activity (caffeine)
  • Neuroprotection by endocannabinoids of the limbic system
    • Adult hippocampal neurogenesis regulation by CB1 receptor
    • Endocannabinoid-mediated neuroprotection against synthetic neurotoxicants of the CNS
  • Intrinsic brain activity modulation by atypical antipsychotics
    • Antipsychotic-induced parkinsonism/schizophrenia (neuronal injury)
    • Antipsychotic-induced dopamine alterations (ex vivo)
      • Iatrogenic dopamine supersensitivity
    • Antipsychotic-induced hyperprolactinemia (HPRL)
    • Antipsychotic-induced oxidative stress
  • Interneuronal quantum coherence in microtubules
    • Quantum entanglement of biophotons and tubulins (superradiance)
    • Orch OR theory of consciousness
  • Neuronal migration, morphogenesis and maturation
  • Synaptogenesis
    • Endocannabinoid-mediated synaptogenesis
  • Monoamine oxidase inhibitors
    • Monoaminergic neurotransmission
  • Synaptic quantum tunnelling
    • Neural synchronicity and communication in the gamma range
  • Supramolecular properties of water in biological systems
    • Vibrational spectrum of biological water resonance
  • Neuronal hypercomputation
    • Neuronal phase coherence
  • Long-term memory formation
  • Vitamin D gene expression
    • Vitamin D binding protein
    • Vitamin D receptor (VDR)
  • Fatty acid binding proteins
  • Self-organized criticality (SOC) in microtubules dynamics
  • Biological utilization of quantum nonlocality
  • Neurexins/neuroligins modulation of endocannabinoid signaling
  • Chronic obstructive pulmonary disease (COPD)
    • Accumulative effects of fine particulate matter (PM2.5) exposure on AECOPD
  • On-demand regulation of homeostatic synaptic plasticity by endocannabinoids
  • Phase-transition-driven synaptic exocytosis and glutamatergic neurotransmission
    • Synaptic phase transitions
    • Voltage-gated calcium channels (VGCC)
  • Reactive microgliosis
    • Microglial internalization
  • Endocannabinoid-mediated retrograde signaling
  • Neuroendocrine system
    • Neurogenesis-mediated serotonergic modulation of stress hormones
  • PM2.5-mediated nanoparticle translocation and internalization
  • Arachidonic acid signaling
  • Quantum cognition
    • Artificial telepathy (Mind reading)
    • Brain-to-brain quantum connectivity
    • Psychocollective consciousness
    • Neuropolitics
  • Fos-like immunoreactivity (FLI)
  • Bioelectromagnetism
  • Experimental parapsychology
    • Psychedelic research
  • Calmodulin-mediated dopaminergic neuromodulation of cognitive memory
  • The radicalisation of science and geoengineering
  • Presynaptic dopamine/calcium signaling and homeostasis
  • Extrasynaptic dopamine/glutamate exocytosis
  • Biological entanglement of optical communication channels in the brain
  • AKT1/GSK3 signaling
  • Purinergic P2X7 receptor
  • Caffeine pharmacodynamics
    • Caffeine-induced diuresis
    • Effects of caffeine on executive function
  • Condensation (monodisperse) aerosols
  • Phenomenology of consciousness/free will
  • MicroRNA (miRNA)
    • PM2.5-mediated TLR signaling and alteration of miRNA expression
  • Social neuroscience
    • The neuroscience of empathy
    • Hyperscanning
    • Mentalization
  • Mirror neurons
  • Limbic resonance
  • Autoimmune limbic encephalitis (LE)
  • Atypical psychosis
  • Organic retrograde amnesia (RA)
  • Dissociative amnesia
  • Remote memory
  • Cognitive flexibility
    • Executive function
  • Fatty acid amide hydrolase (FAAH)
    • Anandamide/CYP2D6 metabolic pharmacokinetics
    • Mecanism-based inactivation of cytochrome P450 isoforms
  • Psychocomputational energetics
  • Atherosclerosis management and prevention
    • Protective effect of garlic on atherosclerosis
  • Synaptic latency
    • Presynaptic action potential
  • Phospholipase C (PLC)
  • Neural transmission asynchrony
  • Neurotelemetry
    • Transparent EEG acquisition
    • Frontal EEG asymmetry
  • Wnt signaling
  • Biophotons
    • Biophotonic quantum beats (coherent energy transfer) in microtubules
  • Oxytocin
    • Oxytocin/vitamin D/anandamide signal transduction
    • Oxytocin trafficking
  • Cyberhomophobia
  • Distant healing
    • The healing power of plants (Biophilia)
  • Quantum biology
    • Quantum coherence in photosynthesis
  • Aripiprazole pharmacodynamics
    • Effects of prolonged, low-dose aripiprazole on the cardiovascular system
    • Aripiprazole functional dopaminergic psychoactivity (pharmacokinetics)
  • Aerosol radiative forcing
  • Lipid rafts
  • Neuroholography
  • Cardioprotection
    • Effects of acetic acid on the cardiovascular system
    • Effects of garlic on the cardiovascular system
  • Neuropsychology of dancing
  • DNA methylation
    • DNA methyltransferase inhibitors
  • Mind-wandering
    • Cannabinoids for racing thoughts
    • Hyperdreaming
    • Task-negative network
  • Cognitive neuronarratology
  • Functionalized gold nanoparticles
  • Clinical relevance of melatonin
    • Cannabinoid-induced attenuation of melatonin synthesis
    • Dopamine/melatonin interactions
  • Participation of endocannabinoid mobilization in REM sleep
  • Atomic singularity of human consciousness
  • Plant protoconsciousness
  • Oneirology
    • Psychological lucidity
  • RNA-guided dopamine neurotransmission
    • Dopamine transcription factors (Nurr1, Notch1)
  • Eicosanoids and docosanoids lipidomics
  • THCA decarboxylation
  • Neurodiversity
  • Metabolic homeostasis
  • Synaptogenic endocannabinoids
    • Arachidonoyl serotonin (AA-5-HT)
    • Docosahexaenoyl serotonin (DHA-5-HT)
    • N-docosahexaenoylethanolamine (DHEA)
    • N-docosahexaenoyl dopamine (DHDA)
  • Tubulin heterodimerization
  • Slow wave sleep (SWS) dreaming
  • Phosphatidylcholine curcumin (Meriva)
  • Axon guidance
  • Novel opioid receptor antagonists
  • Subcellular neuronal quasicrystals
  • Effects of nicotine addiction on psychomotor performance
  • Ionospheric heating
    • Directed ULF/VLF signal propagation in the lower ionosphere
  • Clinical pharmacodynamics of endocannabinoid-based signaling
  • Novel ACE inhibitors
    • ACE-inhibitory activity of probiotic yogurt
  • Caffeine potentiation of cannabinoids transmission
  • THC-mediated RNA interference
  • Human magnetoreception
    • Allocentric spatial memory
  • Deep programming
  • Isoflavones
    • Red clover-derived isoflavone supplementation
  • Drug-induced REM sleep disorders
  • Psychosomatic disorders
  • Nicotinic facilitation of long-term memory
  • Remote ultrasonic neuromodulation of the central nervous system
  • Shared neural pathways in opioid addiction and Alzheimer disease
  • Cognitive neuroimmunity
  • Human neurosecurity
    • Neuroprivacy
    • Neurosurveillance

Endocannabinoid research

The neurocomputational aspects of endocannabinoid-based neuroprotection has emerged as a mature research area. My current research aim to investigate experimental methods for exploiting the endocannabinoid levels for neuroprotection purpose. In particular, the study of retrograde signaling (anandamide trafficking) can be helpful to understand how on-demand anandamide mobilization fine-tune dopamine receptors availability, density, and connectivity in the PFC, striatum, and microglia.

Furthermore, the study of endocannabinoid-mediated synaptic hypercomputation is under investigation. In specific, the role and mecanism of intracellular CB1 activation in the regulation of synchronized gamma-band oscillations (neuronal phase coherence?) by dopamine is poorly documented.

Retrograde signaling dynamics

Notebook:

Research subtopics:

  • Eicosanoids synthesis
  • Microglial/dopamine neuroprotection

Synaptogenic effects of DHA-5-HT, a putative endocannabinoid transporter

Notebook:

Research subtopics:

  • DHA-5-HT signaling
    • Intracellular signal transduction pathways of synaptamide
    • P2X7 receptor pharmacodynamics

See also:

Neuroprotective effects of cannabinoids for traumatic brain injury and drug-induced neuronal damage

Intracellular CB1 activation by cannabinoids (THC) may mediate monoaminergic cross-talk and GPCR receptor heteromization, a potential neuroprotective mecanism for drug-induced neuronal damage.

On-demand programming of neural stem cells by anandamide trafficking

Anandamide trafficking may activate AKT1/CREB signaling (phosphorylation) in the brain.

Anandamide/AKT signaling

Anandamide/Oxytocin signaling

Hypercomputation in living organisms

I aim to understand how biological hypercomputation evolved in living organisms.

Computational domains of synaptic dopamine exocytosis

Quantum-like computational domains in dopaminergic neurons:

Psychocomputational energetics

RNA-guided dopamine neurotransmission and gene expression

The study of RNA-guided dopamine neurotransmission require further research to understand how transcriptional genes (Nurr1, Notch1) influence computational dopamine expression and modulation in vivo.

Solar geoengineering research

Clandestine (solar) geoengineering activity is a source of air pollution and fine particulate matter, a major health and environmental issue.

See also

Food for thoughts

The only thing necessary for the triumph of evil is for good men to do nothing. -Edmund Burke

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