User:Tkadm30/Notebook/Research: Difference between revisions

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'''This page has moved [https://www.isotoperesearch.ca/wiki/User:Tkadm30/Research here]. This page is less frequently updated!'''
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== Research Interests ==
== Research interests ==




Line 9: Line 11:
** Glutaminase
** Glutaminase
* Astrocytes/mitochondria interactions
* Astrocytes/mitochondria interactions
** CB1 expression in hippocampal astrocytes and mitochondria
** Glutamatergic CB1 expression in hippocampal astrocytes and mitochondria
* Astrocytes/microglia interactions
* Astrocytes/microglia interactions
** Astrocytes-mediated neuroprotection (Traumatic brain injury)
** Astrocytes-mediated neuroprotection (Traumatic brain injury)
** Astroglia
** Astroglia
** Astrocyte-neuron lactate 
* Intracellular DHA delivery to corticostriatal neurons
* Intracellular DHA delivery to corticostriatal neurons
** Corticostriatal synaptic plasticity and connectivity
** Corticostriatal synaptic plasticity and connectivity
* Neuroprotective effects of PPAR-gamma agonists  
* Neuroprotective effects of PPAR-gamma agonists  
** Extracellular ATP releases/ATP-mediated gliotransmission
* Extracellular ATP releases (ATP-mediated gliotransmission)
** Effects of adenosine antagonism on retrograde synaptic activity
* Effects of adenosine antagonists on retrograde synaptic activity (caffeine)
* Neuroprotection by endocannabinoids of the limbic system
* Neuroprotection by endocannabinoids of the limbic system
** Adult hippocampal neurogenesis regulation by CB1 receptor
** Adult hippocampal neurogenesis regulation by CB1 receptor
** Endocannabinoid-mediated neuroprotection against synthetic neurotoxicants of the CNS
** Endocannabinoid-mediated neuroprotection against synthetic neurotoxicants of the CNS
* Intrinsic brain activity modulation by atypical antipsychotics
* Intrinsic brain activity modulation by atypical antipsychotics
** Drug-induced parkinsonism/schizophrenia (neuronal injury)
** Antipsychotic-induced parkinsonism/schizophrenia (neuronal injury)
** Antipsychotic-induced dopamine alterations (ex vivo)
** Antipsychotic-induced dopamine alterations (ex vivo)
*** Iatrogenic dopamine supersensitivity
*** Iatrogenic dopamine supersensitivity
** Antipsychotic-induced hyperprolactinemia (HPRL)
** Antipsychotic-induced oxidative stress
* Interneuronal quantum coherence in microtubules
* Interneuronal quantum coherence in microtubules
** Quantum entanglement of biophotons and tubulins (superradiance)
** Quantum entanglement of biophotons and tubulins (superradiance)
Line 37: Line 42:
* Supramolecular properties of water in biological systems
* Supramolecular properties of water in biological systems
** Vibrational spectrum of biological water resonance
** Vibrational spectrum of biological water resonance
* Biological hypercomputation
* Neuronal hypercomputation
** Neuronal phase coherence of synaptic hypercomputation
** Neuronal phase coherence  
* Long-term memory formation
* Long-term memory formation
* Vitamin D gene expression
* Vitamin D gene expression
Line 48: Line 53:
* Neurexins/neuroligins modulation of endocannabinoid signaling
* Neurexins/neuroligins modulation of endocannabinoid signaling
* Chronic obstructive pulmonary disease (COPD)
* Chronic obstructive pulmonary disease (COPD)
** Accumulative effects of metal oxide particulate matter (PM2.5) exposure on AECOPD.
** Accumulative effects of fine particulate matter (PM2.5) exposure on AECOPD
* On-demand regulation of homeostatic synaptic plasticity by endocannabinoids
* On-demand regulation of homeostatic synaptic plasticity by endocannabinoids
* Phase-transition-driven synaptic exocytosis and glutamatergic neurotransmission
* Phase-transition-driven synaptic exocytosis and glutamatergic neurotransmission
** Synaptic phase transition
** Synaptic phase transitions
** Voltage-gated calcium channels (VGCC)
** Voltage-gated calcium channels (VGCC)
* Reactive microgliosis
* Reactive microgliosis
** Microglial internalization
** Microglial internalization
* Endogenous retrograde signaling
* Endocannabinoid-mediated retrograde signaling
* Neuroendocrine system
* Neuroendocrine system
** Neurogenesis-mediated serotonergic modulation of stress hormones
** Neurogenesis-mediated serotonergic modulation of stress hormones
* PM2.5-mediated nanoparticle translocation and internalization  
* PM2.5-mediated nanoparticle translocation and internalization  
* Arachidonic acid
* Arachidonic acid signaling
* Quantum cognition
* Quantum cognition
** Artificial telepathy (Mind reading)
** Artificial telepathy (Mind reading)
** Brain-to-brain quantum connectivity
** Brain-to-brain quantum connectivity
** Psychocollective consciousness
** Psychocollective consciousness
** Neuropolitics
* Fos-like immunoreactivity (FLI)
* Fos-like immunoreactivity (FLI)
* Bioelectromagnetism
* Bioelectromagnetism
Line 70: Line 76:
* Calmodulin-mediated dopaminergic neuromodulation of cognitive memory
* Calmodulin-mediated dopaminergic neuromodulation of cognitive memory
* The radicalisation of science and geoengineering
* The radicalisation of science and geoengineering
* Calcium signaling and homeostasis
* Presynaptic dopamine/calcium signaling and homeostasis
* Extrasynaptic dopamine/glutamate exocytosis
* Extrasynaptic dopamine/glutamate exocytosis
* Biological entanglement of neural communication
* Biological entanglement of optical communication channels in the brain
** Quantum channels in microtubules
* AKT1/GSK3 signaling
* AKT1/GSK3 signaling
* P2X7 purinergic receptor
* Purinergic P2X7 receptor
* Caffeine-induced diuresis
* Caffeine pharmacodynamics
** Caffeine-induced diuresis
** Effects of caffeine on executive function
* Condensation (monodisperse) aerosols
* Condensation (monodisperse) aerosols
* Phenomenology of consciousness/free will
* Phenomenology of consciousness/free will
Line 83: Line 90:
* Social neuroscience
* Social neuroscience
** The neuroscience of empathy
** The neuroscience of empathy
** Hyperscanning
** Mentalization
* Mirror neurons
* Mirror neurons
* Limbic resonance
* Limbic resonance
Line 93: Line 102:
** Executive function
** Executive function
* Fatty acid amide hydrolase (FAAH)
* Fatty acid amide hydrolase (FAAH)
** CYP2D6 metabolic kinetics
** Anandamide/CYP2D6 metabolic pharmacokinetics
* Computational nanoscience
** Mecanism-based inactivation of cytochrome P450 isoforms
** Neurocomputational nanotechnology
* Psychocomputational energetics
* Atherosclerosis management and prevention
* Atherosclerosis management and prevention
** Protective effect of garlic on atherosclerosis
* Synaptic latency
* Synaptic latency
** Presynaptic action potential
** Presynaptic action potential
Line 102: Line 112:
* Neural transmission asynchrony
* Neural transmission asynchrony
* Neurotelemetry
* Neurotelemetry
** Wireless EEG acquisition
** Transparent EEG acquisition
** Frontal EEG asymmetry
* Wnt signaling
* Wnt signaling
* Biophotons
* Biophotons
** Biophotonic quantum beats in microtubules
** Biophotonic quantum beats (coherent energy transfer) in microtubules
* Oxytocin
* Oxytocin
** Oxytocin/vitamin D/anandamide signal transduction
** Oxytocin/vitamin D/anandamide signal transduction
** Oxytocin trafficking
* Cyberhomophobia
* Cyberhomophobia
* Distant healing
* Distant healing
Line 114: Line 126:
** Quantum coherence in photosynthesis
** Quantum coherence in photosynthesis
* Aripiprazole pharmacodynamics
* Aripiprazole pharmacodynamics
** Cardiovascular effects of prolonged, low-dose aripiprazole
** Effects of prolonged, low-dose aripiprazole on the cardiovascular system
** Aripiprazole functional dopaminergic psychoactivity (pharmacokinetics)
* Aerosol radiative forcing
* Aerosol radiative forcing
* Lipid rafts
* Lipid rafts
* Neuroholography
* Neuroholography
* Acetic acid effects on cardiovascular system
* Cardioprotection
** Effects of acetic acid on the cardiovascular system
** Effects of garlic on the cardiovascular system
* Neuropsychology of dancing
* Neuropsychology of dancing
* DNA methyltransferase inhibitors
* DNA methylation
* Mind wandering
** DNA methyltransferase inhibitors
* Mind-wandering
** Cannabinoids for racing thoughts
** Cannabinoids for racing thoughts
** Hyperdreaming
** Task-negative network
* Cognitive neuronarratology
* Functionalized gold nanoparticles
* Clinical relevance of melatonin
** Cannabinoid-induced attenuation of melatonin synthesis
** Dopamine/melatonin interactions
* Participation of endocannabinoid mobilization in REM sleep
* Atomic singularity of human consciousness
* Plant protoconsciousness
* Oneirology
** Psychological lucidity
* RNA-guided dopamine neurotransmission
** Dopamine transcription factors (Nurr1, Notch1)
* Eicosanoids and docosanoids lipidomics
* THCA decarboxylation
* Neurodiversity
* Metabolic homeostasis
* Synaptogenic endocannabinoids
** Arachidonoyl serotonin (AA-5-HT)
** Docosahexaenoyl serotonin (DHA-5-HT)
** N-docosahexaenoylethanolamine (DHEA)
** N-docosahexaenoyl dopamine (DHDA)
* Tubulin heterodimerization
* Slow wave sleep (SWS) dreaming
* Phosphatidylcholine curcumin (Meriva)
* Axon guidance
* Novel opioid receptor antagonists
* Subcellular neuronal quasicrystals
* Effects of nicotine addiction on psychomotor performance
* Ionospheric heating
** Directed ULF/VLF signal propagation in the lower ionosphere
* Clinical pharmacodynamics of endocannabinoid-based signaling
* Novel ACE inhibitors
** ACE-inhibitory activity of probiotic yogurt
* Caffeine potentiation of cannabinoids transmission
* THC-mediated RNA interference
* Human magnetoreception
** Allocentric spatial memory
* Deep programming
* Isoflavones
** Red clover-derived isoflavone supplementation
* Drug-induced REM sleep disorders
* Psychosomatic disorders
* Nicotinic facilitation of long-term memory
* Remote ultrasonic neuromodulation of the central nervous system
* Shared neural pathways in opioid addiction and Alzheimer disease
* Cognitive neuroimmunity
* Human neurosecurity
** Neuroprivacy
** Neurosurveillance


== Retrograde signaling as a novel neuroprotection model ==
== Endocannabinoid research ==
The neuropsychological aspects of endocannabinoid-based neuroprotection has emerged as
The neurocomputational aspects of endocannabinoid-based neuroprotection has emerged as
a mature research area. My current research aim to investigate experimental methods for exploiting
a mature research area. My current research aim to investigate experimental methods for exploiting
the endocannabinoid levels for neuroprotection purpose. In particular, the study of retrograde  
the endocannabinoid levels for neuroprotection purpose. In particular, the study of retrograde  
signaling (anandamide trafficking) can be helpful to understand how endocannabinoid mobilization  
signaling (anandamide trafficking) can be helpful to understand how on-demand anandamide mobilization  
fine-tune monoaminergic receptors availability and synaptogenesis at corticostriatal synapses.  
fine-tune dopamine receptors availability, density, and connectivity in the PFC, striatum, and microglia.
 
Furthermore, the study of endocannabinoid-mediated synaptic hypercomputation is under investigation.
In specific, the role and mecanism of intracellular CB1 activation in the regulation of synchronized gamma-band
oscillations (neuronal phase coherence?) by dopamine is poorly documented.  


=== Intracellular delivery of synaptamide to neurons by endocannabinoids ===
=== Retrograde signaling dynamics ===
This notebook propose a experimental method for intracellular delivery of synaptamide (DHA) to glutamatergic neurons using anandamide trafficking.
Notebook:
* [[User:Etienne_Robillard/Notebook/Endocannabinoids|Endocannabinoids Notebook]]
* [[User:Tkadm30/Notebook/Endocannabinoids|Endocannabinoids Notebook]]
* [[User:Tkadm30/Notebook/Endocannabinoids/Synopsis|Synopsis]]
Research subtopics:
* Eicosanoids synthesis
* '''Microglial/dopamine neuroprotection'''


===Purinergic effects of DHA on glutamate neurotransmission, a putative endocannabinoid enhancer induced by P2X7 agonists===
===Synaptogenic effects of DHA-5-HT, a putative endocannabinoid transporter===
P2X7 receptor mediate synaptogenic DHA signaling and intracellular signal transduction pathways
Notebook:
relevant to PPARgamma-induced neural differentiation. Hence, intracellular CB1 activation may induce PPAR-mediated neural differentiation and proliferation of hippocampal progenitor cells through modulation of purinergic P2X7 receptor.
* [[User:Tkadm30/Notebook/DHA|DHA Notebook]]
* [[User:Etienne_Robillard/Notebook/DHA|DHA Notebook]]
Research subtopics:
* Review: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749532/ Modulation of excitatory neurotransmission by neuronal/glial signalling molecules: interplay between purinergic and glutamatergic systems]
* DHA-5-HT signaling
** Intracellular signal transduction pathways of synaptamide
** P2X7 receptor pharmacodynamics
See also:  
* [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749532/ Modulation of excitatory neurotransmission by neuronal/glial signalling molecules: interplay between purinergic and glutamatergic systems]


===Neuroprotective effects of cannabinoids after traumatic brain injury and drug-induced neuronal damage===
===Neuroprotective effects of cannabinoids for traumatic brain injury and drug-induced neuronal damage===
Intracellular CB1 activation by cannabinoids (THC) may mediate monoaminergic cross-talk and GPCR receptor
Intracellular CB1 activation by cannabinoids (THC) may mediate monoaminergic cross-talk and GPCR receptor
heteromization, a potential neuroprotective mecanism for drug-induced neuronal damage.
heteromization, a potential neuroprotective mecanism for drug-induced neuronal damage.
* [[User:Etienne_Robillard/Notebook/THC|THC Notebook]]
* [[User:Tkadm30/Notebook/THC|THC Notebook]]
* [[User:Etienne_Robillard/Notebook/THCV|THCV Notebook]]
* [[User:Tkadm30/Notebook/THCV|THCV Notebook]]


===On-demand programming of neural stem cells by anandamide trafficking===
===On-demand programming of neural stem cells by anandamide trafficking===
* [[User:Etienne_Robillard/Notebook/Anandamide|Anandamide Notebook]]
Anandamide trafficking may activate AKT1/CREB signaling (phosphorylation) in the brain.
* [[User:Etienne_Robillard/Notebook/AKT1|AKT1 Notebook]]: Anandamide trafficking activate AKT1/CREB signaling
* [[User:Tkadm30/Notebook/Anandamide|Anandamide Notebook]]
** Review: [https://www.ncbi.nlm.nih.gov/pubmed/10749665 The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt.]
====Anandamide/AKT signaling====
* [[User:Tkadm30/Notebook/AKT1|AKT1 Notebook]]
* Review: [https://www.ncbi.nlm.nih.gov/pubmed/10749665 The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt.]
 
====Anandamide/Oxytocin signaling====
* [[User:Tkadm30/Notebook/Oxytocin|Oxytocin Notebook]]
* [https://www.mrnice.nl/forum/9-patients-forum/16287-cannabis-erectile-dysfunction.html Cannabis for erectile dysfunction?]


==Hypercomputation in living organisms==
==Hypercomputation in living organisms==
I aim to understand how biological hypercomputation evolved in living organisms.  
I aim to understand how biological hypercomputation evolved in living organisms.  
* [[User:Etienne_Robillard/Notebook/Hypercomputation|Hypercomputation Notebook]]
* [[User:Tkadm30/Notebook/Hypercomputation|Hypercomputation Notebook]]
* [[User:Etienne_Robillard/Notebook/Synaptic_exocytosis|Synaptic exocytosis Notebook]]
===Computational domains of synaptic dopamine exocytosis===
Quantum-like computational domains in dopaminergic neurons:
* [[User:Tkadm30/Notebook/Synaptic_exocytosis|Synaptic exocytosis Notebook]]
===Psychocomputational energetics===
* [https://www.isotoperesearch.ca/wiki/Psychoenergetics Psychoenergetics Notebook]
 
===RNA-guided dopamine neurotransmission and gene expression===
The study of RNA-guided dopamine neurotransmission require further research to understand
how transcriptional genes (Nurr1, Notch1) influence computational dopamine expression and modulation in vivo.
* [[User:Tkadm30/Notebook/Dopamine|Dopamine Notebook]]
* [[User:Tkadm30/Notebook/miRNA|MicroRNA Notebook]]
 
==Solar geoengineering research==
Clandestine (solar) geoengineering activity is a source of air pollution and fine particulate matter,
a major health and environmental issue.
* [[User:Tkadm30/Notebook/chim_trills_notebook|Notebook]]
* [[User:Tkadm30/Notebook/chim_trills_notebook/Research|Research Notebook]]
 
==See also==
==See also==
* [[User:Etienne_Robillard/Notebook/Brainstorming|Brainstorming]]
* [[User:Tkadm30/Notebook/Brainstorming|Brainstorming]]
 
==Food for thoughts==
<blockquote>
The only thing necessary for the triumph of evil is for good men to do nothing. -Edmund Burke
</blockquote>

Latest revision as of 03:40, 9 February 2019

This page has moved here. This page is less frequently updated!

Research interests

  • Aluminium-induced oxidative stress and chronic neuroinflammation of the CNS
    • Gulf war syndrome
  • Glutamatergic system/neurotransmission
    • Glutamate-induced NMDA excitotoxicity
    • Glutaminase
  • Astrocytes/mitochondria interactions
    • Glutamatergic CB1 expression in hippocampal astrocytes and mitochondria
  • Astrocytes/microglia interactions
    • Astrocytes-mediated neuroprotection (Traumatic brain injury)
    • Astroglia
    • Astrocyte-neuron lactate
  • Intracellular DHA delivery to corticostriatal neurons
    • Corticostriatal synaptic plasticity and connectivity
  • Neuroprotective effects of PPAR-gamma agonists
  • Extracellular ATP releases (ATP-mediated gliotransmission)
  • Effects of adenosine antagonists on retrograde synaptic activity (caffeine)
  • Neuroprotection by endocannabinoids of the limbic system
    • Adult hippocampal neurogenesis regulation by CB1 receptor
    • Endocannabinoid-mediated neuroprotection against synthetic neurotoxicants of the CNS
  • Intrinsic brain activity modulation by atypical antipsychotics
    • Antipsychotic-induced parkinsonism/schizophrenia (neuronal injury)
    • Antipsychotic-induced dopamine alterations (ex vivo)
      • Iatrogenic dopamine supersensitivity
    • Antipsychotic-induced hyperprolactinemia (HPRL)
    • Antipsychotic-induced oxidative stress
  • Interneuronal quantum coherence in microtubules
    • Quantum entanglement of biophotons and tubulins (superradiance)
    • Orch OR theory of consciousness
  • Neuronal migration, morphogenesis and maturation
  • Synaptogenesis
    • Endocannabinoid-mediated synaptogenesis
  • Monoamine oxidase inhibitors
    • Monoaminergic neurotransmission
  • Synaptic quantum tunnelling
    • Neural synchronicity and communication in the gamma range
  • Supramolecular properties of water in biological systems
    • Vibrational spectrum of biological water resonance
  • Neuronal hypercomputation
    • Neuronal phase coherence
  • Long-term memory formation
  • Vitamin D gene expression
    • Vitamin D binding protein
    • Vitamin D receptor (VDR)
  • Fatty acid binding proteins
  • Self-organized criticality (SOC) in microtubules dynamics
  • Biological utilization of quantum nonlocality
  • Neurexins/neuroligins modulation of endocannabinoid signaling
  • Chronic obstructive pulmonary disease (COPD)
    • Accumulative effects of fine particulate matter (PM2.5) exposure on AECOPD
  • On-demand regulation of homeostatic synaptic plasticity by endocannabinoids
  • Phase-transition-driven synaptic exocytosis and glutamatergic neurotransmission
    • Synaptic phase transitions
    • Voltage-gated calcium channels (VGCC)
  • Reactive microgliosis
    • Microglial internalization
  • Endocannabinoid-mediated retrograde signaling
  • Neuroendocrine system
    • Neurogenesis-mediated serotonergic modulation of stress hormones
  • PM2.5-mediated nanoparticle translocation and internalization
  • Arachidonic acid signaling
  • Quantum cognition
    • Artificial telepathy (Mind reading)
    • Brain-to-brain quantum connectivity
    • Psychocollective consciousness
    • Neuropolitics
  • Fos-like immunoreactivity (FLI)
  • Bioelectromagnetism
  • Experimental parapsychology
    • Psychedelic research
  • Calmodulin-mediated dopaminergic neuromodulation of cognitive memory
  • The radicalisation of science and geoengineering
  • Presynaptic dopamine/calcium signaling and homeostasis
  • Extrasynaptic dopamine/glutamate exocytosis
  • Biological entanglement of optical communication channels in the brain
  • AKT1/GSK3 signaling
  • Purinergic P2X7 receptor
  • Caffeine pharmacodynamics
    • Caffeine-induced diuresis
    • Effects of caffeine on executive function
  • Condensation (monodisperse) aerosols
  • Phenomenology of consciousness/free will
  • MicroRNA (miRNA)
    • PM2.5-mediated TLR signaling and alteration of miRNA expression
  • Social neuroscience
    • The neuroscience of empathy
    • Hyperscanning
    • Mentalization
  • Mirror neurons
  • Limbic resonance
  • Autoimmune limbic encephalitis (LE)
  • Atypical psychosis
  • Organic retrograde amnesia (RA)
  • Dissociative amnesia
  • Remote memory
  • Cognitive flexibility
    • Executive function
  • Fatty acid amide hydrolase (FAAH)
    • Anandamide/CYP2D6 metabolic pharmacokinetics
    • Mecanism-based inactivation of cytochrome P450 isoforms
  • Psychocomputational energetics
  • Atherosclerosis management and prevention
    • Protective effect of garlic on atherosclerosis
  • Synaptic latency
    • Presynaptic action potential
  • Phospholipase C (PLC)
  • Neural transmission asynchrony
  • Neurotelemetry
    • Transparent EEG acquisition
    • Frontal EEG asymmetry
  • Wnt signaling
  • Biophotons
    • Biophotonic quantum beats (coherent energy transfer) in microtubules
  • Oxytocin
    • Oxytocin/vitamin D/anandamide signal transduction
    • Oxytocin trafficking
  • Cyberhomophobia
  • Distant healing
    • The healing power of plants (Biophilia)
  • Quantum biology
    • Quantum coherence in photosynthesis
  • Aripiprazole pharmacodynamics
    • Effects of prolonged, low-dose aripiprazole on the cardiovascular system
    • Aripiprazole functional dopaminergic psychoactivity (pharmacokinetics)
  • Aerosol radiative forcing
  • Lipid rafts
  • Neuroholography
  • Cardioprotection
    • Effects of acetic acid on the cardiovascular system
    • Effects of garlic on the cardiovascular system
  • Neuropsychology of dancing
  • DNA methylation
    • DNA methyltransferase inhibitors
  • Mind-wandering
    • Cannabinoids for racing thoughts
    • Hyperdreaming
    • Task-negative network
  • Cognitive neuronarratology
  • Functionalized gold nanoparticles
  • Clinical relevance of melatonin
    • Cannabinoid-induced attenuation of melatonin synthesis
    • Dopamine/melatonin interactions
  • Participation of endocannabinoid mobilization in REM sleep
  • Atomic singularity of human consciousness
  • Plant protoconsciousness
  • Oneirology
    • Psychological lucidity
  • RNA-guided dopamine neurotransmission
    • Dopamine transcription factors (Nurr1, Notch1)
  • Eicosanoids and docosanoids lipidomics
  • THCA decarboxylation
  • Neurodiversity
  • Metabolic homeostasis
  • Synaptogenic endocannabinoids
    • Arachidonoyl serotonin (AA-5-HT)
    • Docosahexaenoyl serotonin (DHA-5-HT)
    • N-docosahexaenoylethanolamine (DHEA)
    • N-docosahexaenoyl dopamine (DHDA)
  • Tubulin heterodimerization
  • Slow wave sleep (SWS) dreaming
  • Phosphatidylcholine curcumin (Meriva)
  • Axon guidance
  • Novel opioid receptor antagonists
  • Subcellular neuronal quasicrystals
  • Effects of nicotine addiction on psychomotor performance
  • Ionospheric heating
    • Directed ULF/VLF signal propagation in the lower ionosphere
  • Clinical pharmacodynamics of endocannabinoid-based signaling
  • Novel ACE inhibitors
    • ACE-inhibitory activity of probiotic yogurt
  • Caffeine potentiation of cannabinoids transmission
  • THC-mediated RNA interference
  • Human magnetoreception
    • Allocentric spatial memory
  • Deep programming
  • Isoflavones
    • Red clover-derived isoflavone supplementation
  • Drug-induced REM sleep disorders
  • Psychosomatic disorders
  • Nicotinic facilitation of long-term memory
  • Remote ultrasonic neuromodulation of the central nervous system
  • Shared neural pathways in opioid addiction and Alzheimer disease
  • Cognitive neuroimmunity
  • Human neurosecurity
    • Neuroprivacy
    • Neurosurveillance

Endocannabinoid research

The neurocomputational aspects of endocannabinoid-based neuroprotection has emerged as a mature research area. My current research aim to investigate experimental methods for exploiting the endocannabinoid levels for neuroprotection purpose. In particular, the study of retrograde signaling (anandamide trafficking) can be helpful to understand how on-demand anandamide mobilization fine-tune dopamine receptors availability, density, and connectivity in the PFC, striatum, and microglia.

Furthermore, the study of endocannabinoid-mediated synaptic hypercomputation is under investigation. In specific, the role and mecanism of intracellular CB1 activation in the regulation of synchronized gamma-band oscillations (neuronal phase coherence?) by dopamine is poorly documented.

Retrograde signaling dynamics

Notebook:

Research subtopics:

  • Eicosanoids synthesis
  • Microglial/dopamine neuroprotection

Synaptogenic effects of DHA-5-HT, a putative endocannabinoid transporter

Notebook:

Research subtopics:

  • DHA-5-HT signaling
    • Intracellular signal transduction pathways of synaptamide
    • P2X7 receptor pharmacodynamics

See also:

Neuroprotective effects of cannabinoids for traumatic brain injury and drug-induced neuronal damage

Intracellular CB1 activation by cannabinoids (THC) may mediate monoaminergic cross-talk and GPCR receptor heteromization, a potential neuroprotective mecanism for drug-induced neuronal damage.

On-demand programming of neural stem cells by anandamide trafficking

Anandamide trafficking may activate AKT1/CREB signaling (phosphorylation) in the brain.

Anandamide/AKT signaling

Anandamide/Oxytocin signaling

Hypercomputation in living organisms

I aim to understand how biological hypercomputation evolved in living organisms.

Computational domains of synaptic dopamine exocytosis

Quantum-like computational domains in dopaminergic neurons:

Psychocomputational energetics

RNA-guided dopamine neurotransmission and gene expression

The study of RNA-guided dopamine neurotransmission require further research to understand how transcriptional genes (Nurr1, Notch1) influence computational dopamine expression and modulation in vivo.

Solar geoengineering research

Clandestine (solar) geoengineering activity is a source of air pollution and fine particulate matter, a major health and environmental issue.

See also

Food for thoughts

The only thing necessary for the triumph of evil is for good men to do nothing. -Edmund Burke

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