User:Tkadm30/Notebook/Research: Difference between revisions

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'''This page has moved [https://www.isotoperesearch.ca/wiki/User:Tkadm30/Research here]. This page is less frequently updated!'''
__TOC__
__TOC__
== Research Interests ==
== Research interests ==




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** Astrocytes-mediated neuroprotection (Traumatic brain injury)
** Astrocytes-mediated neuroprotection (Traumatic brain injury)
** Astroglia
** Astroglia
** Astrocyte-neuron lactate 
* Intracellular DHA delivery to corticostriatal neurons
* Intracellular DHA delivery to corticostriatal neurons
** Corticostriatal synaptic plasticity and connectivity
** Corticostriatal synaptic plasticity and connectivity
Line 39: Line 42:
* Supramolecular properties of water in biological systems
* Supramolecular properties of water in biological systems
** Vibrational spectrum of biological water resonance
** Vibrational spectrum of biological water resonance
* Biological hypercomputation
* Neuronal hypercomputation
** Neuronal phase coherence of synaptic hypercomputation
** Neuronal phase coherence  
* Long-term memory formation
* Long-term memory formation
* Vitamin D gene expression
* Vitamin D gene expression
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* Calmodulin-mediated dopaminergic neuromodulation of cognitive memory
* Calmodulin-mediated dopaminergic neuromodulation of cognitive memory
* The radicalisation of science and geoengineering
* The radicalisation of science and geoengineering
* Presynaptic calcium signaling and homeostasis
* Presynaptic dopamine/calcium signaling and homeostasis
* Extrasynaptic dopamine/glutamate exocytosis
* Extrasynaptic dopamine/glutamate exocytosis
* Biological entanglement of optical communication channels in the brain
* Biological entanglement of optical communication channels in the brain
* AKT1/GSK3 signaling
* AKT1/GSK3 signaling
* Purinergic P2X7 receptor
* Purinergic P2X7 receptor
* Caffeine-induced diuresis
* Caffeine pharmacodynamics
** Caffeine-induced diuresis
** Effects of caffeine on executive function
* Condensation (monodisperse) aerosols
* Condensation (monodisperse) aerosols
* Phenomenology of consciousness/free will
* Phenomenology of consciousness/free will
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* Social neuroscience
* Social neuroscience
** The neuroscience of empathy
** The neuroscience of empathy
** Hyperscanning
** Mentalization
* Mirror neurons
* Mirror neurons
* Limbic resonance
* Limbic resonance
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** Anandamide/CYP2D6 metabolic pharmacokinetics
** Anandamide/CYP2D6 metabolic pharmacokinetics
** Mecanism-based inactivation of cytochrome P450 isoforms
** Mecanism-based inactivation of cytochrome P450 isoforms
* Biocomputational nanoscience
* Psychocomputational energetics
** Neurocomputational nanotechnology
** Neurocomputational nanodevices
* Atherosclerosis management and prevention
* Atherosclerosis management and prevention
** Protective effect of garlic on atherosclerosis
** Protective effect of garlic on atherosclerosis
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* Neural transmission asynchrony
* Neural transmission asynchrony
* Neurotelemetry
* Neurotelemetry
** Wireless EEG acquisition
** Transparent EEG acquisition
** Frontal EEG asymmetry
* Wnt signaling
* Wnt signaling
* Biophotons
* Biophotons
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* Ionospheric heating
* Ionospheric heating
** Directed ULF/VLF signal propagation in the lower ionosphere
** Directed ULF/VLF signal propagation in the lower ionosphere
* Clinical pharmacodynamics of cannabinoids toxicity
* Clinical pharmacodynamics of endocannabinoid-based signaling
* ACE inhibitors
* Novel ACE inhibitors
** ACE-inhibitory activity of probiotic yogurt
* Caffeine potentiation of cannabinoids transmission
* THC-mediated RNA interference
* Human magnetoreception
** Allocentric spatial memory
* Deep programming
* Isoflavones
** Red clover-derived isoflavone supplementation
* Drug-induced REM sleep disorders
* Psychosomatic disorders
* Nicotinic facilitation of long-term memory
* Remote ultrasonic neuromodulation of the central nervous system
* Shared neural pathways in opioid addiction and Alzheimer disease
* Cognitive neuroimmunity
* Human neurosecurity
** Neuroprivacy
** Neurosurveillance


== Endocannabinoid research ==
== Endocannabinoid research ==
Line 173: Line 196:
the endocannabinoid levels for neuroprotection purpose. In particular, the study of retrograde  
the endocannabinoid levels for neuroprotection purpose. In particular, the study of retrograde  
signaling (anandamide trafficking) can be helpful to understand how on-demand anandamide mobilization  
signaling (anandamide trafficking) can be helpful to understand how on-demand anandamide mobilization  
fine-tune monoaminergic receptors availability and synaptogenesis in the PFC and microglia.  
fine-tune dopamine receptors availability, density, and connectivity in the PFC, striatum, and microglia.  


Furthermore, the study of endocannabinoid-mediated synaptic hypercomputation is under investigation.
Furthermore, the study of endocannabinoid-mediated synaptic hypercomputation is under investigation.
In specific, the role and mecanism of intracellular CB1 activation in the regulation of synchronized gamma-band  
In specific, the role and mecanism of intracellular CB1 activation in the regulation of synchronized gamma-band  
oscillations (neuronal phase coherence?) is poorly understood.  
oscillations (neuronal phase coherence?) by dopamine is poorly documented.  


=== Retrograde signaling dynamics ===
=== Retrograde signaling dynamics ===
Notebook:
Notebook:
* [[User:Etienne_Robillard/Notebook/Endocannabinoids|Endocannabinoids Notebook]]
* [[User:Tkadm30/Notebook/Endocannabinoids|Endocannabinoids Notebook]]
* [[User:Etienne_Robillard/Notebook/Endocannabinoids/Synopsis|Synopsis]]
* [[User:Tkadm30/Notebook/Endocannabinoids/Synopsis|Synopsis]]
Research subtopics:
Research subtopics:
* Eicosanoids synthesis
* Eicosanoids synthesis
* Microglial neuroprotection
* '''Microglial/dopamine neuroprotection'''


===Synaptogenic effects of DHA-5-HT, a putative endocannabinoid transporter===
===Synaptogenic effects of DHA-5-HT, a putative endocannabinoid transporter===
Notebook:
Notebook:
* [[User:Etienne_Robillard/Notebook/DHA|DHA Notebook]]
* [[User:Tkadm30/Notebook/DHA|DHA Notebook]]
Research subtopics:
Research subtopics:
* DHA-5-HT signaling
* DHA-5-HT signaling
Line 199: Line 222:
===Neuroprotective effects of cannabinoids for traumatic brain injury and drug-induced neuronal damage===
===Neuroprotective effects of cannabinoids for traumatic brain injury and drug-induced neuronal damage===
Intracellular CB1 activation by cannabinoids (THC) may mediate monoaminergic cross-talk and GPCR receptor
Intracellular CB1 activation by cannabinoids (THC) may mediate monoaminergic cross-talk and GPCR receptor
heteromization, a potential neuroprotective mecanism for glutamate-induced neuronal damage.
heteromization, a potential neuroprotective mecanism for drug-induced neuronal damage.
* [[User:Etienne_Robillard/Notebook/THC|THC Notebook]]
* [[User:Tkadm30/Notebook/THC|THC Notebook]]
* [[User:Etienne_Robillard/Notebook/THCV|THCV Notebook]]
* [[User:Tkadm30/Notebook/THCV|THCV Notebook]]


===On-demand programming of neural stem cells by anandamide trafficking===
===On-demand programming of neural stem cells by anandamide trafficking===
Anandamide trafficking may activate AKT1/CREB signaling (phosphorylation) in the brain.
Anandamide trafficking may activate AKT1/CREB signaling (phosphorylation) in the brain.
* [[User:Etienne_Robillard/Notebook/Anandamide|Anandamide Notebook]]
* [[User:Tkadm30/Notebook/Anandamide|Anandamide Notebook]]
====Anandamide/AKT signaling====
====Anandamide/AKT signaling====
* [[User:Etienne_Robillard/Notebook/AKT1|AKT1 Notebook]]
* [[User:Tkadm30/Notebook/AKT1|AKT1 Notebook]]
* Review: [https://www.ncbi.nlm.nih.gov/pubmed/10749665 The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt.]
* Review: [https://www.ncbi.nlm.nih.gov/pubmed/10749665 The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt.]


====Anandamide/Oxytocin signaling====
====Anandamide/Oxytocin signaling====
* [[User:Etienne_Robillard/Notebook/Oxytocin|Oxytocin Notebook]]
* [[User:Tkadm30/Notebook/Oxytocin|Oxytocin Notebook]]
* [https://www.mrnice.nl/forum/9-patients-forum/16287-cannabis-erectile-dysfunction.html Cannabis for erectile dysfunction?]


==Hypercomputation in living organisms==
==Hypercomputation in living organisms==
I aim to understand how biological hypercomputation evolved in living organisms.  
I aim to understand how biological hypercomputation evolved in living organisms.  
* [[User:Etienne_Robillard/Notebook/Hypercomputation|Hypercomputation Notebook]]
* [[User:Tkadm30/Notebook/Hypercomputation|Hypercomputation Notebook]]
===Computational domains of dopamine exocytosis===
===Computational domains of synaptic dopamine exocytosis===
Quantum-like computational domains in dopaminergic neurons:
Quantum-like computational domains in dopaminergic neurons:
* [[User:Etienne_Robillard/Notebook/Synaptic_exocytosis|Synaptic exocytosis Notebook]]
* [[User:Tkadm30/Notebook/Synaptic_exocytosis|Synaptic exocytosis Notebook]]
===Psychocomputational energetics===
* [https://www.isotoperesearch.ca/wiki/Psychoenergetics Psychoenergetics Notebook]


===RNA-guided dopamine neurotransmission and gene expression===
===RNA-guided dopamine neurotransmission and gene expression===
The study of RNA-guided dopamine neurotransmission require further research to understand
The study of RNA-guided dopamine neurotransmission require further research to understand
how transcriptional genes (Nurr1, Notch1) influence computational dopamine expression and modulation in vivo.
how transcriptional genes (Nurr1, Notch1) influence computational dopamine expression and modulation in vivo.
* [[User:Etienne_Robillard/Notebook/Dopamine|Dopamine Notebook]]
* [[User:Tkadm30/Notebook/Dopamine|Dopamine Notebook]]
* [[User:Etienne_Robillard/Notebook/miRNA|MicroRNA Notebook]]
* [[User:Tkadm30/Notebook/miRNA|MicroRNA Notebook]]


==Geoengineering research==
==Solar geoengineering research==
Clandestine geoengineering activity is a source of air pollution and fine particulate matter,
Clandestine (solar) geoengineering activity is a source of air pollution and fine particulate matter,
a major health and environmental issue.
a major health and environmental issue.
* [[User:Etienne_Robillard/Notebook/chim_trills_notebook|Notebook]]
* [[User:Tkadm30/Notebook/chim_trills_notebook|Notebook]]
* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/Research|Research Notebook]]
* [[User:Tkadm30/Notebook/chim_trills_notebook/Research|Research Notebook]]


==See also==
==See also==
* [[User:Etienne_Robillard/Notebook/Brainstorming|Brainstorming]]
* [[User:Tkadm30/Notebook/Brainstorming|Brainstorming]]
 
==Food for thoughts==
<blockquote>
The only thing necessary for the triumph of evil is for good men to do nothing. -Edmund Burke
</blockquote>

Latest revision as of 03:40, 9 February 2019

This page has moved here. This page is less frequently updated!

Research interests

  • Aluminium-induced oxidative stress and chronic neuroinflammation of the CNS
    • Gulf war syndrome
  • Glutamatergic system/neurotransmission
    • Glutamate-induced NMDA excitotoxicity
    • Glutaminase
  • Astrocytes/mitochondria interactions
    • Glutamatergic CB1 expression in hippocampal astrocytes and mitochondria
  • Astrocytes/microglia interactions
    • Astrocytes-mediated neuroprotection (Traumatic brain injury)
    • Astroglia
    • Astrocyte-neuron lactate
  • Intracellular DHA delivery to corticostriatal neurons
    • Corticostriatal synaptic plasticity and connectivity
  • Neuroprotective effects of PPAR-gamma agonists
  • Extracellular ATP releases (ATP-mediated gliotransmission)
  • Effects of adenosine antagonists on retrograde synaptic activity (caffeine)
  • Neuroprotection by endocannabinoids of the limbic system
    • Adult hippocampal neurogenesis regulation by CB1 receptor
    • Endocannabinoid-mediated neuroprotection against synthetic neurotoxicants of the CNS
  • Intrinsic brain activity modulation by atypical antipsychotics
    • Antipsychotic-induced parkinsonism/schizophrenia (neuronal injury)
    • Antipsychotic-induced dopamine alterations (ex vivo)
      • Iatrogenic dopamine supersensitivity
    • Antipsychotic-induced hyperprolactinemia (HPRL)
    • Antipsychotic-induced oxidative stress
  • Interneuronal quantum coherence in microtubules
    • Quantum entanglement of biophotons and tubulins (superradiance)
    • Orch OR theory of consciousness
  • Neuronal migration, morphogenesis and maturation
  • Synaptogenesis
    • Endocannabinoid-mediated synaptogenesis
  • Monoamine oxidase inhibitors
    • Monoaminergic neurotransmission
  • Synaptic quantum tunnelling
    • Neural synchronicity and communication in the gamma range
  • Supramolecular properties of water in biological systems
    • Vibrational spectrum of biological water resonance
  • Neuronal hypercomputation
    • Neuronal phase coherence
  • Long-term memory formation
  • Vitamin D gene expression
    • Vitamin D binding protein
    • Vitamin D receptor (VDR)
  • Fatty acid binding proteins
  • Self-organized criticality (SOC) in microtubules dynamics
  • Biological utilization of quantum nonlocality
  • Neurexins/neuroligins modulation of endocannabinoid signaling
  • Chronic obstructive pulmonary disease (COPD)
    • Accumulative effects of fine particulate matter (PM2.5) exposure on AECOPD
  • On-demand regulation of homeostatic synaptic plasticity by endocannabinoids
  • Phase-transition-driven synaptic exocytosis and glutamatergic neurotransmission
    • Synaptic phase transitions
    • Voltage-gated calcium channels (VGCC)
  • Reactive microgliosis
    • Microglial internalization
  • Endocannabinoid-mediated retrograde signaling
  • Neuroendocrine system
    • Neurogenesis-mediated serotonergic modulation of stress hormones
  • PM2.5-mediated nanoparticle translocation and internalization
  • Arachidonic acid signaling
  • Quantum cognition
    • Artificial telepathy (Mind reading)
    • Brain-to-brain quantum connectivity
    • Psychocollective consciousness
    • Neuropolitics
  • Fos-like immunoreactivity (FLI)
  • Bioelectromagnetism
  • Experimental parapsychology
    • Psychedelic research
  • Calmodulin-mediated dopaminergic neuromodulation of cognitive memory
  • The radicalisation of science and geoengineering
  • Presynaptic dopamine/calcium signaling and homeostasis
  • Extrasynaptic dopamine/glutamate exocytosis
  • Biological entanglement of optical communication channels in the brain
  • AKT1/GSK3 signaling
  • Purinergic P2X7 receptor
  • Caffeine pharmacodynamics
    • Caffeine-induced diuresis
    • Effects of caffeine on executive function
  • Condensation (monodisperse) aerosols
  • Phenomenology of consciousness/free will
  • MicroRNA (miRNA)
    • PM2.5-mediated TLR signaling and alteration of miRNA expression
  • Social neuroscience
    • The neuroscience of empathy
    • Hyperscanning
    • Mentalization
  • Mirror neurons
  • Limbic resonance
  • Autoimmune limbic encephalitis (LE)
  • Atypical psychosis
  • Organic retrograde amnesia (RA)
  • Dissociative amnesia
  • Remote memory
  • Cognitive flexibility
    • Executive function
  • Fatty acid amide hydrolase (FAAH)
    • Anandamide/CYP2D6 metabolic pharmacokinetics
    • Mecanism-based inactivation of cytochrome P450 isoforms
  • Psychocomputational energetics
  • Atherosclerosis management and prevention
    • Protective effect of garlic on atherosclerosis
  • Synaptic latency
    • Presynaptic action potential
  • Phospholipase C (PLC)
  • Neural transmission asynchrony
  • Neurotelemetry
    • Transparent EEG acquisition
    • Frontal EEG asymmetry
  • Wnt signaling
  • Biophotons
    • Biophotonic quantum beats (coherent energy transfer) in microtubules
  • Oxytocin
    • Oxytocin/vitamin D/anandamide signal transduction
    • Oxytocin trafficking
  • Cyberhomophobia
  • Distant healing
    • The healing power of plants (Biophilia)
  • Quantum biology
    • Quantum coherence in photosynthesis
  • Aripiprazole pharmacodynamics
    • Effects of prolonged, low-dose aripiprazole on the cardiovascular system
    • Aripiprazole functional dopaminergic psychoactivity (pharmacokinetics)
  • Aerosol radiative forcing
  • Lipid rafts
  • Neuroholography
  • Cardioprotection
    • Effects of acetic acid on the cardiovascular system
    • Effects of garlic on the cardiovascular system
  • Neuropsychology of dancing
  • DNA methylation
    • DNA methyltransferase inhibitors
  • Mind-wandering
    • Cannabinoids for racing thoughts
    • Hyperdreaming
    • Task-negative network
  • Cognitive neuronarratology
  • Functionalized gold nanoparticles
  • Clinical relevance of melatonin
    • Cannabinoid-induced attenuation of melatonin synthesis
    • Dopamine/melatonin interactions
  • Participation of endocannabinoid mobilization in REM sleep
  • Atomic singularity of human consciousness
  • Plant protoconsciousness
  • Oneirology
    • Psychological lucidity
  • RNA-guided dopamine neurotransmission
    • Dopamine transcription factors (Nurr1, Notch1)
  • Eicosanoids and docosanoids lipidomics
  • THCA decarboxylation
  • Neurodiversity
  • Metabolic homeostasis
  • Synaptogenic endocannabinoids
    • Arachidonoyl serotonin (AA-5-HT)
    • Docosahexaenoyl serotonin (DHA-5-HT)
    • N-docosahexaenoylethanolamine (DHEA)
    • N-docosahexaenoyl dopamine (DHDA)
  • Tubulin heterodimerization
  • Slow wave sleep (SWS) dreaming
  • Phosphatidylcholine curcumin (Meriva)
  • Axon guidance
  • Novel opioid receptor antagonists
  • Subcellular neuronal quasicrystals
  • Effects of nicotine addiction on psychomotor performance
  • Ionospheric heating
    • Directed ULF/VLF signal propagation in the lower ionosphere
  • Clinical pharmacodynamics of endocannabinoid-based signaling
  • Novel ACE inhibitors
    • ACE-inhibitory activity of probiotic yogurt
  • Caffeine potentiation of cannabinoids transmission
  • THC-mediated RNA interference
  • Human magnetoreception
    • Allocentric spatial memory
  • Deep programming
  • Isoflavones
    • Red clover-derived isoflavone supplementation
  • Drug-induced REM sleep disorders
  • Psychosomatic disorders
  • Nicotinic facilitation of long-term memory
  • Remote ultrasonic neuromodulation of the central nervous system
  • Shared neural pathways in opioid addiction and Alzheimer disease
  • Cognitive neuroimmunity
  • Human neurosecurity
    • Neuroprivacy
    • Neurosurveillance

Endocannabinoid research

The neurocomputational aspects of endocannabinoid-based neuroprotection has emerged as a mature research area. My current research aim to investigate experimental methods for exploiting the endocannabinoid levels for neuroprotection purpose. In particular, the study of retrograde signaling (anandamide trafficking) can be helpful to understand how on-demand anandamide mobilization fine-tune dopamine receptors availability, density, and connectivity in the PFC, striatum, and microglia.

Furthermore, the study of endocannabinoid-mediated synaptic hypercomputation is under investigation. In specific, the role and mecanism of intracellular CB1 activation in the regulation of synchronized gamma-band oscillations (neuronal phase coherence?) by dopamine is poorly documented.

Retrograde signaling dynamics

Notebook:

Research subtopics:

  • Eicosanoids synthesis
  • Microglial/dopamine neuroprotection

Synaptogenic effects of DHA-5-HT, a putative endocannabinoid transporter

Notebook:

Research subtopics:

  • DHA-5-HT signaling
    • Intracellular signal transduction pathways of synaptamide
    • P2X7 receptor pharmacodynamics

See also:

Neuroprotective effects of cannabinoids for traumatic brain injury and drug-induced neuronal damage

Intracellular CB1 activation by cannabinoids (THC) may mediate monoaminergic cross-talk and GPCR receptor heteromization, a potential neuroprotective mecanism for drug-induced neuronal damage.

On-demand programming of neural stem cells by anandamide trafficking

Anandamide trafficking may activate AKT1/CREB signaling (phosphorylation) in the brain.

Anandamide/AKT signaling

Anandamide/Oxytocin signaling

Hypercomputation in living organisms

I aim to understand how biological hypercomputation evolved in living organisms.

Computational domains of synaptic dopamine exocytosis

Quantum-like computational domains in dopaminergic neurons:

Psychocomputational energetics

RNA-guided dopamine neurotransmission and gene expression

The study of RNA-guided dopamine neurotransmission require further research to understand how transcriptional genes (Nurr1, Notch1) influence computational dopamine expression and modulation in vivo.

Solar geoengineering research

Clandestine (solar) geoengineering activity is a source of air pollution and fine particulate matter, a major health and environmental issue.

See also

Food for thoughts

The only thing necessary for the triumph of evil is for good men to do nothing. -Edmund Burke

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