User:Tkadm30/Notebook/Research

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Research Interests

  • Stress-induced neuroinflammation of the hippocampus/CNS
  • Glutamatergic system/neurotransmission
    • Glutamate-induced excitotoxicity
  • Astrocytes/mitochondria
    • CB1 expression in hippocampal astrocytes and mitochondria
  • Intracellular DHA delivery to striatal neurons
  • Neuroprotective effects of PPAR-gamma agonists
    • Extracellular ATP releases/ATP-mediated gliotransmission
    • Effects of adenosine antagonism on retrograde synaptic activity
  • Neuroprotection by endocannabinoids of the hippocampus
    • Adult hippocampal neurogenesis regulation by CB1 receptor
    • Endocannabinoid-mediated neuroprotection against synthetic neurotoxicants of the CNS
  • Intrinsic brain activity modulation by atypical antipsychotics
    • Drug-induced parkinsonism/schizophrenia
    • Dopamine hypersensitivity
  • Interneuronal quantum coherence in microtubules: Implications for quantum processing of consciousness and free will
    • Orch OR theory of consciousness
    • Neuronal morphogenesis and maturation
    • Synaptogenesis
  • Monoamine oxidase inhibitors
    • Monoaminergic neurotransmission
  • Synaptic quantum tunnelling
  • Supramolecular properties of water in biological systems
    • Vibrational spectrum of biological water activity
  • Biological hypercomputation
    • Phase coherence of synaptic hypercomputation
  • Long-term memory formation
  • Vitamin D binding protein
  • Fatty acid binding proteins
  • Self-organized criticality (SOC) in microtubules dynamics
  • Biological utilization of quantum nonlocality
  • Neurexins/neuroligins modulation of endocannabinoid signaling
  • Chronic obstructive pulmonary disease (COPD)

Retrograde signaling as a novel neuroprotection platform

The neuropsychological aspects of endocannabinoid based neuroprotection has emerged as a mature research area. My current research aim to investigate methods for exploiting the endocannabinoid levels for neuroprotection purpose.

Intracellular delivery of synaptamide to neurons by endocannabinoids

This notebook propose a experimental method for delivery of DHA to hippocampal stem/progenitor cells using endocannabinoid-mediated retrograde signaling.

Purinergic effects of DHA on neurotransmission, a putative endocannabinoid induced by P2X7 agonists

P2X7 receptor mediate synaptogenic DHA signaling and intracellular signal transduction pathways relevant to PPAR-induced neural differentiation. Hence, intracellular THC delivery may induce PPAR-dependent activity for DHA-mediated neural differentiation and proliferation of hippocampal progenitor cells through modulation of P2X7 receptor.

Neuroprotective effects of cannabinoids after traumatic brain injury and drug-induced neuronal damage

Programming of hippocampal progenitor cells by anandamide trafficking

Hypercomputation in living organisms

I aim to understand how biological hypercomputation evolved in living organisms.