User:Tkadm30/Notebook/Research
Research Interests
- Aluminium-induced oxidative stress and chronic neuroinflammation of the CNS
- Gulf war syndrome
- Glutamatergic system/neurotransmission
- Glutamate-induced excitotoxicity
- Glutaminase
- Astrocytes/mitochondria interactions
- CB1 expression in hippocampal astrocytes and mitochondria
- Astrocytes/microglia interactions
- Astrocytes-mediated neuroprotection
- Astroglia
- Intracellular DHA delivery to corticostriatal neurons
- Corticostriatal synaptic plasticity
- Neuroprotective effects of PPAR-gamma agonists
- Extracellular ATP releases/ATP-mediated gliotransmission
- Effects of adenosine antagonism on retrograde synaptic activity
- Neuroprotection by endocannabinoids of the hippocampus
- Adult hippocampal neurogenesis regulation by CB1 receptor
- Endocannabinoid-mediated neuroprotection against synthetic neurotoxicants of the CNS
- Intrinsic brain activity modulation by atypical antipsychotics
- Drug-induced parkinsonism/schizophrenia (neuronal injury)
- Antipsychotic-induced dopamine alterations (ex vivo)
- Interneuronal quantum coherence in microtubules
- Quantum entanglement of consciousness
- Orch OR theory of consciousness
- Neuronal migration, morphogenesis and maturation
- Synaptogenesis
- Monoamine oxidase inhibitors
- Monoaminergic neurotransmission
- Synaptic quantum tunnelling
- Neural synchrony and communication in the gamma range
- Supramolecular properties of water in biological systems
- Vibrational spectrum of biological water activity
- Biological hypercomputation
- Neuronal phase coherence of synaptic hypercomputation
- Long-term memory formation
- Vitamin D binding protein
- Fatty acid binding proteins
- Self-organized criticality (SOC) in microtubules dynamics
- Biological utilization of quantum nonlocality
- Neurexins/neuroligins modulation of endocannabinoid signaling
- Chronic obstructive pulmonary disease (COPD)
- Accumulative effects of metal oxide particulate matter (PM2.5) exposure on AECOPD.
- On-demand regulation of homeostatic synaptic plasticity by endocannabinoids
- Phase-transition-driven synaptic exocytosis and glutamatergic neurotransmission
- Synaptic phase transition
- Voltage-gated calcium channels (VGCC)
- Reactive microgliosis
- microglial internalization
- Endogenous retrograde signaling
- Neuroendocrine system
- Neurogenesis-mediated serotonergic modulation of stress hormones
- PM2.5-mediated nanoparticle translocation and internalization
- Arachidonic acid
- Quantum cognition
- Artificial telepathy (Mind reading)
- Brain-to-brain quantum connectivity
- Collective consciousness
- Fos-like immunoreactivity (FLI)
- Bioelectromagnetism
- Experimental parapsychology
- Neural synchronicity
- Calmodulin-mediated dopaminergic neuromodulation of cognitive memory
- The radicalisation of science and geoengineering
- Calcium signaling and homeostasis
- Extrasynaptic dopamine exocytosis
- Biological entanglement of neural communication
- Quantum channels in microtubules
- AKT1/GSK3 signaling
- P2X7 purinergic receptor
- Caffeine-induced diuresis
- Condensation (monodisperse) aerosols
- Phenomenology of consciousness/free will
- MicroRNA (miRNA)
- PM2.5-mediated TLR signaling and alteration of miRNA expression
- Social neuroscience
- The neuroscience of empathy
- Mirror neurons
- Limbic resonance
- Autoimmune limbic encephalitis (LE)
- Atypical psychosis
- Cognitive flexibility
- Fatty acid amide hydrolase (FAAH)
Retrograde signaling as a novel neuroprotection model
The neuropsychological aspects of endocannabinoid based neuroprotection has emerged as a mature research area. My current research aim to investigate methods for exploiting the endocannabinoid levels for neuroprotection purpose. In particular, the study of retrograde signaling (trafficking) can be helpful to understand how endocannabinoid activity fine-tune dopaminergic receptors availability and synaptic connectivity.
Intracellular delivery of synaptamide to neurons by endocannabinoids
This notebook propose a experimental method for intracellular delivery of synaptamide (DHA) to glutamatergic neurons using anandamide trafficking.
Purinergic effects of DHA on glutamate neurotransmission, a putative endocannabinoid induced by P2X7 agonists
P2X7 receptor mediate synaptogenic DHA signaling and intracellular signal transduction pathways relevant to PPARgamma-induced neural differentiation. Hence, intracellular CB1 activation may induce PPAR-mediated neural differentiation and proliferation of hippocampal progenitor cells through modulation of purinergic P2X7 receptor.
- DHA Notebook
- Review: Modulation of excitatory neurotransmission by neuronal/glial signalling molecules: interplay between purinergic and glutamatergic systems
Neuroprotective effects of cannabinoids after traumatic brain injury and drug-induced neuronal damage
Intracellular CB1 activation by cannabinoids (THC) may mediate dopaminergic cross-talk and GPCR receptor heteromization, a potential neuroprotective mecanism for drug-induced neuronal damage.
On-demand programming of neural stem cells by anandamide trafficking
- Anandamide Notebook
- AKT1 Notebook: Anandamide trafficking activate AKT1/CREB signaling
Hypercomputation in living organisms
I aim to understand how biological hypercomputation evolved in living organisms.
