User:Tkadm30/Notebook/Research: Difference between revisions
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* [[User:Etienne_Robillard/Notebook/Endocannabinoids|Endocannabinoid Notebook]] | * [[User:Etienne_Robillard/Notebook/Endocannabinoids|Endocannabinoid Notebook]] | ||
=== Synaptogenic effects of DHA on neurotransmission, a putative endocannabinoid=== | === Synaptogenic effects of DHA on neurotransmission, a putative endocannabinoid induced by THC=== | ||
P2X7 receptor mediate synaptogenic DHA signaling and intracellular signal transduction pathways | P2X7 receptor mediate synaptogenic DHA signaling and intracellular signal transduction pathways | ||
relevant to PPAR-induced neural differentiation. | relevant to PPAR-induced neural differentiation. Hence, intracellular THC delivery may induce PPAR-dependent | ||
pathways for DHA-mediated neural differentiation and proliferation of hippocampal progenitor cells through | |||
modulation of P2X7 receptor. | |||
* [[User:Etienne_Robillard/Notebook/DHA|DHA Notebook]] | * [[User:Etienne_Robillard/Notebook/DHA|DHA Notebook]] | ||
* [[User:Etienne_Robillard/Notebook/P2X7|P2X7 Notebook]] | * [[User:Etienne_Robillard/Notebook/P2X7|P2X7 Notebook]] | ||
* [[User:Etienne_Robillard/Notebook/THC|THC Notebook]] | |||
=== Programming of hippocampal progenitor cells by anandamide trafficking === | === Programming of hippocampal progenitor cells by anandamide trafficking === | ||
* [[User:Etienne_Robillard/Notebook/Anandamide|Anandamide Notebook]] | * [[User:Etienne_Robillard/Notebook/Anandamide|Anandamide Notebook]] | ||
Revision as of 06:52, 16 November 2015
Research Interests
- Neuroinflammation of the hippocampus/CNS
- Glutamatergic system/neurotransmission
- Glutamate neurotoxicity
- Astrocytes/microglia
- DHA
- P2X7 receptor
- Adult hippocampal neurogenesis
- Endocannabinoid-mediated neuroprotection agaisnt synthetic neurotoxicants of the CNS.
- Aerosol delivery of polymeric nanoparticles
- Water-soluble synthetic polymers as exotic drug delivery carriers
Endocannabinoids as a novel therapeutic platform
The neuropsychological aspects of endocannabinoid based neuroprotection has emerged as a mature research area. My current research aim to investigate methods for exploiting the endocannabinoids platform for neurocognitive therapy.
Intracellular delivery of synaptamide to neurons by endocannabinoids
This notebook propose a experimental method for delivery of DHA to hippocampal stem/progenitor cells using endocannabinoid-mediated retrograde signaling.
Synaptogenic effects of DHA on neurotransmission, a putative endocannabinoid induced by THC
P2X7 receptor mediate synaptogenic DHA signaling and intracellular signal transduction pathways relevant to PPAR-induced neural differentiation. Hence, intracellular THC delivery may induce PPAR-dependent pathways for DHA-mediated neural differentiation and proliferation of hippocampal progenitor cells through modulation of P2X7 receptor.
