User:Tkadm30/Notebook/Research: Difference between revisions
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modulation of P2X7 receptor. | modulation of P2X7 receptor. | ||
* [[User:Etienne_Robillard/Notebook/DHA|DHA Notebook]] | * [[User:Etienne_Robillard/Notebook/DHA|DHA Notebook]] | ||
* [[User:Etienne_Robillard/Notebook/THC|THC Notebook]] | * [[User:Etienne_Robillard/Notebook/THC|THC Notebook]] | ||
=== Programming of hippocampal progenitor cells by anandamide trafficking === | === Programming of hippocampal progenitor cells by anandamide trafficking === | ||
* [[User:Etienne_Robillard/Notebook/Anandamide|Anandamide Notebook]] | * [[User:Etienne_Robillard/Notebook/Anandamide|Anandamide Notebook]] | ||
Revision as of 04:45, 23 February 2016
Research Interests
- Stress-induced neuroinflammation of the hippocampus/CNS
- Glutamatergic system/neurotransmission
- Glutamate-induced excitotoxicity
- Astrocytes/mitochondria
- CB1 expression in hippocampal astrocytes and mitochondria
- Intracellular DHA delivery to striatal neurons
- Neuroprotective effects of P2X7 agonists
- Extracellular ATP releases/ATP-mediated gliotransmission
- Effects of adenosine receptors on 2-AG mediated synaptic activity
- Neuroprotection by endocannabinoids of the hippocampus
- Adult hippocampal neurogenesis regulation by CB1 receptor
- Endocannabinoid-mediated neuroprotection against synthetic neurotoxicants of the CNS
- Intrinsic brain activity modulation by atypical antipsychotics
- Drug-induced parkinsonism
- Quantum coherence in microtubules: Implications for quantum processing of consciousness and free will
- Orch OR theory of consciousness
- monoamine oxidase inhibitors
- monoaminergic neurotransmission
Endocannabinoids as a novel therapeutic platform
The neuropsychological aspects of endocannabinoid based neuroprotection has emerged as a mature research area. My current research aim to investigate methods for exploiting the endocannabinoids platform for neurocognitive therapy.
Intracellular delivery of synaptamide to neurons by endocannabinoids
This notebook propose a experimental method for delivery of DHA to hippocampal stem/progenitor cells using endocannabinoid-mediated retrograde signaling.
Purinergic effects of DHA on neurotransmission, a putative endocannabinoid induced by P2X7 agonists
P2X7 receptor mediate synaptogenic DHA signaling and intracellular signal transduction pathways relevant to PPAR-induced neural differentiation. Hence, intracellular THC delivery may induce PPAR-dependent pathways for DHA-mediated neural differentiation and proliferation of hippocampal progenitor cells through modulation of P2X7 receptor.
