User:Tkadm30/Notebook/Research: Difference between revisions
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** Monoaminergic neurotransmission | ** Monoaminergic neurotransmission | ||
* Synaptic exocytosis | * Synaptic exocytosis | ||
* Supramolecular properties of water in biological systems | |||
** Vibrational spectrum of water | |||
== Endocannabinoids as a novel therapeutic platform == | == Endocannabinoids as a novel therapeutic platform == | ||
Revision as of 05:21, 8 March 2016
Research Interests
- Stress-induced neuroinflammation of the hippocampus/CNS
- Glutamatergic system/neurotransmission
- Glutamate-induced excitotoxicity
- Astrocytes/mitochondria
- CB1 expression in hippocampal astrocytes and mitochondria
- Intracellular DHA delivery to striatal neurons
- Neuroprotective effects of P2X7 agonists
- Extracellular ATP releases/ATP-mediated gliotransmission
- Effects of adenosine receptors on 2-AG mediated synaptic activity
- Neuroprotection by endocannabinoids of the hippocampus
- Adult hippocampal neurogenesis regulation by CB1 receptor
- Endocannabinoid-mediated neuroprotection against synthetic neurotoxicants of the CNS
- Intrinsic brain activity modulation by atypical antipsychotics
- Drug-induced parkinsonism
- Quantum coherence in microtubules: Implications for quantum processing of consciousness and free will
- Orch OR theory of consciousness
- Neuronal morphogenesis
- Monoamine oxidase inhibitors
- Monoaminergic neurotransmission
- Synaptic exocytosis
- Supramolecular properties of water in biological systems
- Vibrational spectrum of water
Endocannabinoids as a novel therapeutic platform
The neuropsychological aspects of endocannabinoid based neuroprotection has emerged as a mature research area. My current research aim to investigate methods for exploiting the endocannabinoids platform for neurocognitive therapy.
Intracellular delivery of synaptamide to neurons by endocannabinoids
This notebook propose a experimental method for delivery of DHA to hippocampal stem/progenitor cells using endocannabinoid-mediated retrograde signaling.
Purinergic effects of DHA on neurotransmission, a putative endocannabinoid induced by P2X7 agonists
P2X7 receptor mediate synaptogenic DHA signaling and intracellular signal transduction pathways relevant to PPAR-induced neural differentiation. Hence, intracellular THC delivery may induce PPAR-dependent pathways for DHA-mediated neural differentiation and proliferation of hippocampal progenitor cells through modulation of P2X7 receptor.
