User:Tkadm30/Notebook/Research

Research Interests

• Aluminium-induced oxidative stress and chronic neuroinflammation of the CNS
  • Gulf war syndrome
• Glutamatergic system/neurotransmission
  • Glutamate-induced NMDA excitotoxicity
  • Glutaminase
• Astrocytes/mitochondria interactions
  • Glutamatergic CB1 expression in hippocampal astrocytes and mitochondria
• Astrocytes/microglia interactions
  • Astrocytes-mediated neuroprotection (Traumatic brain injury)
  • Astroglia
• Intracellular DHA delivery to corticostriatal neurons
  • Corticostriatal synaptic plasticity and connectivity
• Neuroprotective effects of PPAR-gamma agonists
• Extracellular ATP releases (ATP-mediated gliotransmission)
• Effects of adenosine antagonists on retrograde synaptic activity (caffeine)
• Neuroprotection by endocannabinoids of the limbic system
  • Adult hippocampal neurogenesis regulation by CB1 receptor
  • Endocannabinoid-mediated neuroprotection against synthetic neurotoxicants of the CNS
• Intrinsic brain activity modulation by atypical antipsychotics
  • Drug-induced parkinsonism/schizophrenia (neuronal injury)
  • Antipsychotic-induced dopamine alterations (ex vivo)
    • Iatrogenic dopamine supersensitivity
  • Antipsychotic-induced hyperprolactinemia (HPRL)
  • Antipsychotic-induced oxidative stress
• Interneuronal quantum coherence in microtubules
  • Quantum entanglement of biophotons and tubulins (superradiance)
  • Orch OR theory of consciousness
• Neuronal migration, morphogenesis and maturation
• Synaptogenesis
  • Endocannabinoid-mediated synaptogenesis
• Monoamine oxidase inhibitors
  • Monoaminergic neurotransmission
• Synaptic quantum tunnelling
  • Neural synchronicity and communication in the gamma range
• Supramolecular properties of water in biological systems
  • Vibrational spectrum of biological water resonance
• Biological hypercomputation
  • Neuronal phase coherence of synaptic hypercomputation
• Long-term memory formation
• Vitamin D gene expression
  • Vitamin D binding protein
  • Vitamin D receptor (VDR)
• Fatty acid binding proteins
• Self-organized criticality (SOC) in microtubules dynamics
• Biological utilization of quantum nonlocality
• Neurexins/neuroligins modulation of endocannabinoid signaling
• Chronic obstructive pulmonary disease (COPD)
  • Accumulative effects of fine particulate matter (PM2.5) exposure on AECOPD
• On-demand regulation of homeostatic synaptic plasticity by endocannabinoids
• Phase-transition-driven synaptic exocytosis and glutamatergic neurotransmission
  • Synaptic phase transitions
  • Voltage-gated calcium channels (VGCC)
• Reactive microgliosis
  • Microglial internalization
• Endocannabinoid-mediated retrograde signaling
• Neuroendocrine system
  • Neurogenesis-mediated serotonergic modulation of stress hormones
• PM2.5-mediated nanoparticle translocation and internalization
• Arachidonic acid signaling
• Quantum cognition
  • Artificial telepathy (Mind reading)
  • Brain-to-brain quantum connectivity
  • Psychocollective consciousness
• Fos-like immunoreactivity (FLI)
• Bioelectromagnetism
• Experimental parapsychology
  • Psychedelic research
• Calmodulin-mediated dopaminergic neuromodulation of cognitive memory
• The radicalisation of science and geoengineering
• Presynaptic calcium signaling and homeostasis
• Extrasynaptic dopamine/glutamate exocytosis
• Biological entanglement of optical communication channels in the brain
• AKT1/GSK3 signaling
• P2X7 purinergic receptor
• Caffeine-induced diuresis
• Condensation (monodisperse) aerosols
• Phenomenology of consciousness/free will
• MicroRNA (miRNA)
  • PM2.5-mediated TLR signaling and alteration of miRNA expression
• Social neuroscience
  • The neuroscience of empathy
• Mirror neurons
• Limbic resonance
• Autoimmune limbic encephalitis (LE)
• Atypical psychosis
• Organic retrograde amnesia (RA)
• Dissociative amnesia
• Remote memory
• Cognitive flexibility
  • Executive function
• Fatty acid amide hydrolase (FAAH)
  • CYP2D6 metabolic kinetics
• Biocomputational nanoscience
  • Neurocomputational nanotechnology
  • Neurocomputational nanodevices
• Atherosclerosis management and prevention
  • Protective effect of garlic on atherosclerosis
• Synaptic latency
  • Presynaptic action potential
• Phospholipase C (PLC)
• Neural transmission asynchrony
• Neurotelemetry
  • Wireless EEG acquisition
• Wnt signaling
• Biophotons
  • Biophotonic quantum beats in microtubules
• Oxytocin
  • Oxytocin/vitamin D/anandamide signal transduction
  • Oxytocin trafficking
• Cyberhomophobia
• Distant healing
  • The healing power of plants (Biophilia)
• Quantum biology
  • Quantum coherence in photosynthesis
• Aripiprazole pharmacodynamics
  • Effects of prolonged, low-dose aripiprazole on the cardiovascular system
  • Aripiprazole functional dopaminergic psychoactivity (pharmacokinetics)
• Aerosol radiative forcing
• Lipid rafts
• Neuroholography
• Cardioprotection
  • Effects of acetic acid on the cardiovascular system
  • Effects of garlic on the cardiovascular system
• Neuropsychology of dancing
• DNA methyltransferase inhibitors
• Mind-wandering
  • Cannabinoids for racing thoughts
  • Hyperdreaming
  • Task-negative network
• Proppian morphology
• Functionalized gold nanoparticles
• Clinical relevance of melatonin
  • Cannabinoid-induced attenuation of melatonin synthesis
  • Dopamine/melatonin interactions
• Participation of endocannabinoid mobilization in REM sleep
• Atomic singularity
• Plant protoconsciousness
• Oneirology
  • Psychological lucidity
• RNA-guided dopamine neurotransmission
  • Dopamine transcription factors (Nurr1)
• Eicosanoids and docosanoids lipidomics
• THCA decarboxylation
• Neurodiversity

Retrograde signaling as a novel neuroprotection model

The neuropsychological aspects of endocannabinoid-based neuroprotection has emerged as a mature research area. My current research aim to investigate experimental methods for exploiting the endocannabinoid levels for neuroprotection purpose. In particular, the study of retrograde signaling (anandamide trafficking) can be helpful to understand how endocannabinoid mobilization fine-tune monoaminergic receptors availability and synaptogenesis at corticostriatal synapses.

Intracellular delivery of synaptamide to neurons by endocannabinoids

This notebook propose a experimental method for intracellular delivery of synaptamide (DHA) to glutamatergic neurons using anandamide trafficking.

• Endocannabinoids Notebook

Purinergic effects of DHA on glutamate neurotransmission, a putative endocannabinoid transporter induced by P2X7 agonists

P2X7 receptor mediate synaptogenic DHA signaling and intracellular signal transduction pathways relevant to PPARgamma-induced neural differentiation. Hence, intracellular CB1 activation may induce PPAR-mediated neural differentiation and proliferation of hippocampal progenitor cells through modulation of purinergic P2X7 receptor.

• DHA Notebook
• Review: Modulation of excitatory neurotransmission by neuronal/glial signalling molecules: interplay between purinergic and glutamatergic systems

Neuroprotective effects of cannabinoids after traumatic brain injury and drug-induced neuronal damage

Intracellular CB1 activation by cannabinoids (THC) may mediate monoaminergic cross-talk and GPCR receptor heteromization, a potential neuroprotective mecanism for drug-induced neuronal damage.

• THC Notebook
• THCV Notebook

On-demand programming of neural stem cells by anandamide trafficking

Anandamide trafficking may activate AKT1/CREB signaling (phosphorylation) in the brain.

• Anandamide Notebook
• AKT1 Notebook
• Oxytocin Notebook
• Review: The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt.

Hypercomputation in living organisms

I aim to understand how biological hypercomputation evolved in living organisms.

• Hypercomputation Notebook
• Synaptic exocytosis Notebook

RNA-guided dopamine neurotransmission and gene expression

The study of RNA-guided dopamine neurotransmission require further research to understand how transcriptional genes (Nurr1) influence dopamine releases.

• Dopamine Notebook
• MicroRNA Notebook

See also

• Brainstorming