User:Etienne Robillard/Notebook/Rhodopsin

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(Rhodopsin kinase phosphorylation notes)
Current revision (09:23, 19 December 2014) (view source)
 
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* '''Answer''': Temporary! The bat can recover its vision if the GABA receptor is cleaved from cAMP/ATP dependent competitive ligands, thus allowing GPCR based signal transduction to occur normally. [[http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=500792&ID=419426 REACTOME]]  
* '''Answer''': Temporary! The bat can recover its vision if the GABA receptor is cleaved from cAMP/ATP dependent competitive ligands, thus allowing GPCR based signal transduction to occur normally. [[http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=500792&ID=419426 REACTOME]]  
** Notice also that the S1PR4 gene is a '''near-neighboor''' of the Cannabinoid receptors! (Hint hint)
** Notice also that the S1PR4 gene is a '''near-neighboor''' of the Cannabinoid receptors! (Hint hint)
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* Question 2: Why peoples affected by chim trills are blind as a bat or unaware of the dangerosity of such experiments?
== Rhodopsin kinase phosphorylation notes ==
== Rhodopsin kinase phosphorylation notes ==
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* Laclq plasmid: ?
* Laclq plasmid: ?
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== Chim Trills/Coffeine notes (GlyT1) ==
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== Chim Trills/Caffeine connection? ==
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* [http://www.sciencedaily.com/releases/2012/10/121003132012.htm Caffeinated coffee linked to vision loss]
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* [http://www.cerveauetpsycho.fr/ewb_pages/a/article-du-cafe-contre-la-maladie-d-alzheimer-32896.php Du café contre la maladie d’Alzheimer ?]
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* [http://www.ncbi.nlm.nih.gov/pubmed/19581723 Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic mice.]
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* [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756438/ Caffeine inhibition of ionotropic glycine receptors]
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* [http://www.ncbi.nlm.nih.gov/pubmed/19562643 Glycine transport inhibitors for the treatment of schizophrenia: symptom and disease modification.]
* Calcium binding (via N-Methyl-D-aspartate ionotropic Receptor, therefore a photosensitive toggle switch) -> glycine receptor affinity/modulation (ie: coffeine)  
* Calcium binding (via N-Methyl-D-aspartate ionotropic Receptor, therefore a photosensitive toggle switch) -> glycine receptor affinity/modulation (ie: coffeine)  
* Best known as [[http://www.kegg.jp/dbget-bin/www_bget?dr:D10186 GlyT1]]: <font color=red>{4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}{5-(methylsulfonyl)-2-[(1S)-2,2,2-trifluoro-1-methylethoxy]phenyl}methanone</font COLOR>   
* Best known as [[http://www.kegg.jp/dbget-bin/www_bget?dr:D10186 GlyT1]]: <font color=red>{4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}{5-(methylsulfonyl)-2-[(1S)-2,2,2-trifluoro-1-methylethoxy]phenyl}methanone</font COLOR>   

Current revision

Contents

References on Rhodopsin

Unresolved questions

  • Question 1: In the expression "blind as a bat", is the bat blindness a permanent or temporary phenomenon and how could you assert this is related to cGMP/ATP based phosphorylation of the Rhodopsin kinase?
  • Answer: Temporary! The bat can recover its vision if the GABA receptor is cleaved from cAMP/ATP dependent competitive ligands, thus allowing GPCR based signal transduction to occur normally. [REACTOME]
    • Notice also that the S1PR4 gene is a near-neighboor of the Cannabinoid receptors! (Hint hint)
  • Question 2: Why peoples affected by chim trills are blind as a bat or unaware of the dangerosity of such experiments?

Rhodopsin kinase phosphorylation notes

  • Agent Chim Trills  : Scooby Doo is anti-biotic sensitive.
  • NMDAR induced Rho phosphorylation: a bi-directional visual memory addressing (recognition) and high-frequency modulation through light activated Glycine/Chloride receptors (experimental disassociative anesthesia): [1], [2]

Autophosphorylation notes

  • Laclq (LuxR) sensitive chromophore (EGFP) -> Rho kinase? (thus a purely leaky biobrick)
  • Laclq plasmid: ?

Chim Trills/Caffeine connection?


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