User:Etienne Robillard/Notebook/Rhodopsin

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(References on Rhodopsin)
(References on Rhodopsin)
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* http://pfam.sanger.ac.uk/family/PF00001
* http://pfam.sanger.ac.uk/family/PF00001
* http://www.wikigenes.org/e/gene/e/212541.html
* http://www.wikigenes.org/e/gene/e/212541.html
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* "Furthermore, we demonstrate that crosstalk between the Ras and Rho GTPase families is involved in cAMP-dependent processing of amyloid precursor protein (APP), a key protein in Alzheimer's disease [7]." http://www.wikigenes.org/e/ref/e/12819788.html
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* "Furthermore, we demonstrate that crosstalk between the Ras and Rho GTPase families is involved in cAMP-dependent processing of amyloid precursor protein (APP), <font color=red>a key protein in Alzheimer's disease</font> [7]." http://www.wikigenes.org/e/ref/e/12819788.html
* "'''Photocaging''' involves the covalent addition of a small molecule effector (e.g., IPTG or doxycyline) onto another molecule (the cage) that upon addition of light such as UV, releases the effector molecule to perform a task. The cage group typically consists of aromatic rings, such as '''ortho-nitrobenzyl''' moieties, that undergoes photolytic cleavage to unmask the target molecule. This permits the spatiotemporal control of gene function upon light stimulation. The caging of IPTG, for instance, permits the temporal control of genes under the control of the Lac operator." [[http://openwetware.org/wiki/CH391L/S12/LightSensors 1]]
* "'''Photocaging''' involves the covalent addition of a small molecule effector (e.g., IPTG or doxycyline) onto another molecule (the cage) that upon addition of light such as UV, releases the effector molecule to perform a task. The cage group typically consists of aromatic rings, such as '''ortho-nitrobenzyl''' moieties, that undergoes photolytic cleavage to unmask the target molecule. This permits the spatiotemporal control of gene function upon light stimulation. The caging of IPTG, for instance, permits the temporal control of genes under the control of the Lac operator." [[http://openwetware.org/wiki/CH391L/S12/LightSensors 1]]
* Evidences of [http://www.brenda-enzymes.org/php/result_flat.php4?ecno=3.1.4.35&Suchword=&organism%5B%5D=Drosophila+melanogaster&show_tm=0 EC 3.1.4.35] (CNP precursor) activity from Rhodopsin induced photoactivation in Drosophila flies: http://openwetware.org/wiki/BIO254:Phototransduction
* Evidences of [http://www.brenda-enzymes.org/php/result_flat.php4?ecno=3.1.4.35&Suchword=&organism%5B%5D=Drosophila+melanogaster&show_tm=0 EC 3.1.4.35] (CNP precursor) activity from Rhodopsin induced photoactivation in Drosophila flies: http://openwetware.org/wiki/BIO254:Phototransduction

Revision as of 09:06, 17 May 2013

References on Rhodopsin

Unresolved questions

  • Question 1: In the expression "blind as a bat", is the bat blindness a permanent or temporary phenomenon and how could you assert this is related to cGMP/ATP based phosphorylation of the Rhodopsin kinase?
  • Answer: Temporary! The bat can recover its vision if the GABA receptor is cleaved from cAMP/ATP dependent competitive ligands, thus allowing GPCR based signal transduction to occur normally. [REACTOME]
    • Notice also that the S1PR4 gene is a near-neighboor of the Cannabinoid receptors! (Hint hint)

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