User:Tkadm30/Notebook/Rhodopsin: Difference between revisions

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* http://pfam.sanger.ac.uk/family/PF00001
* http://pfam.sanger.ac.uk/family/PF00001
* http://www.wikigenes.org/e/gene/e/212541.html
* http://www.wikigenes.org/e/gene/e/212541.html
* "Furthermore, we demonstrate that crosstalk between the Ras and Rho GTPase families is involved in cAMP-dependent processing of amyloid precursor protein (APP), a key protein in Alzheimer's disease [7]." http://www.wikigenes.org/e/ref/e/12819788.html
* "Furthermore, we demonstrate that crosstalk between the Ras and Rho GTPase families is involved in cAMP-dependent processing of amyloid precursor protein (APP), <font color=red>a key protein in Alzheimer's disease</font> [7]." http://www.wikigenes.org/e/ref/e/12819788.html
* Synthetic, recombinant light sensors: http://openwetware.org/wiki/CH391L/S12/LightSensors
* [http://www.vetmed.vt.edu/education/curriculum/vm8054/eye/RHODOPSN.HTM The Rhodopsin Cycle]
* [http://www.vetmed.vt.edu/education/curriculum/vm8054/eye/CNSPROC.HTM Processing of Visual Signals]
* [http://www.accessexcellence.org/AE/AEC/CC/vision_background.php How We See: The First Steps of Human Vision]
* [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2780 GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2] : A human protein implicated in visual memory, cognition, and perception of light-induced stimulus from rhodopsin-mediated promoter. (Best known as transducin) - Location (Human): Chromosome 1p13. Check also the OMIM entry [http://omim.org/entry/139340 here].
* http://youtu.be/IP4zsbemW8I : Beta-arrestins primer (see http://en.wikipedia.org/wiki/Arrestin and this [http://www.ncbi.nlm.nih.gov/pubmed/15845844 paper].)
 
== Unresolved questions ==
* Question 1: In the expression "'''blind as a bat'''", is the bat blindness a permanent or temporary phenomenon and '''how''' could you assert this is related to cGMP/ATP based phosphorylation of the Rhodopsin kinase?
* '''Answer''': Temporary! The bat can recover its vision if the GABA receptor is cleaved from cAMP/ATP dependent competitive ligands, thus allowing GPCR based signal transduction to occur normally. [[http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=500792&ID=419426 REACTOME]]
** Notice also that the S1PR4 gene is a '''near-neighboor''' of the Cannabinoid receptors! (Hint hint)
* Question 2: Why peoples affected by chim trills are blind as a bat or unaware of the dangerosity of such experiments?
 
== Rhodopsin kinase phosphorylation notes ==
* Agent Chim Trills  : Scooby Doo is anti-biotic sensitive.
* NMDAR induced Rho phosphorylation: a bi-directional visual memory addressing (recognition) and high-frequency modulation through light activated Glycine/Chloride receptors ('''experimental disassociative anesthesia'''): [[http://udini.proquest.com/view/studies-of-glycine-activated-pqid:1872897281/ 1]], [[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222487 2]]
 
 
== Chim Trills/Caffeine connection? ==
* [http://www.sciencedaily.com/releases/2012/10/121003132012.htm Caffeinated coffee linked to vision loss]
* [http://www.cerveauetpsycho.fr/ewb_pages/a/article-du-cafe-contre-la-maladie-d-alzheimer-32896.php Du café contre la maladie d’Alzheimer ?]
* [http://www.ncbi.nlm.nih.gov/pubmed/19581723 Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic mice.]
* [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756438/ Caffeine inhibition of ionotropic glycine receptors]
* [http://www.ncbi.nlm.nih.gov/pubmed/19562643 Glycine transport inhibitors for the treatment of schizophrenia: symptom and disease modification.]
* Calcium binding (via N-Methyl-D-aspartate ionotropic Receptor, therefore a photosensitive toggle switch) -> glycine receptor affinity/modulation (ie: coffeine)
* Best known as [[http://www.kegg.jp/dbget-bin/www_bget?dr:D10186 GlyT1]]: <font color=red>{4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}{5-(methylsulfonyl)-2-[(1S)-2,2,2-trifluoro-1-methylethoxy]phenyl}methanone</font COLOR> 
 
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"Do the right thing. It will gratify some people and astonish the rest." - Mark Twain

Revision as of 05:07, 20 September 2015

References on Rhodopsin

Unresolved questions

  • Question 1: In the expression "blind as a bat", is the bat blindness a permanent or temporary phenomenon and how could you assert this is related to cGMP/ATP based phosphorylation of the Rhodopsin kinase?
  • Answer: Temporary! The bat can recover its vision if the GABA receptor is cleaved from cAMP/ATP dependent competitive ligands, thus allowing GPCR based signal transduction to occur normally. [REACTOME]
    • Notice also that the S1PR4 gene is a near-neighboor of the Cannabinoid receptors! (Hint hint)
  • Question 2: Why peoples affected by chim trills are blind as a bat or unaware of the dangerosity of such experiments?

Rhodopsin kinase phosphorylation notes

  • Agent Chim Trills  : Scooby Doo is anti-biotic sensitive.
  • NMDAR induced Rho phosphorylation: a bi-directional visual memory addressing (recognition) and high-frequency modulation through light activated Glycine/Chloride receptors (experimental disassociative anesthesia): [1], [2]


Chim Trills/Caffeine connection?

"Do the right thing. It will gratify some people and astonish the rest." - Mark Twain

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