User:Etienne Robillard/Notebook/Schiff base

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(Introduction to Schiff bases)
(Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl carbanion)
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* Insert text here in scientifically acceptable way (ie: without grammar errors) to explain the functions and basics of [http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation Schiff base formation]. [1]  
* Insert text here in scientifically acceptable way (ie: without grammar errors) to explain the functions and basics of [http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation Schiff base formation]. [1]  
 +
 +
=== Schiff bases conjugated pharmacological intermediates and N-substituted heterocyclics carbenes ===
 +
* Present summarly the basic psychopharmacological aspects/functions of imine in a biological system .
* Present summarly the basic psychopharmacological aspects/functions of imine in a biological system .
** pharmacological intermediates (N-substituted heterocyclics)
** pharmacological intermediates (N-substituted heterocyclics)
** Nucleophilic carbonyl addition
** Nucleophilic carbonyl addition
 +
** PS: <font color="red">Yb(OTf)3</font> route to '''1,2,3,4-tetrahydroisoquinolines''' derivatives.
 +
** Micheal addition=>PS (Pictet-Spengler asymmetric synthesis of 1,2,3,4-tetrahydroisoquinolines)
-
=== Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl carbanion ===
+
=== Schiff bases as quorum sensing molecules (AHL) and Serine-dependent osmolitic regulators/ATP synthase ===
-
* For the long story, see [[Phenylmethylamine]]: A nucleophilic Schiff base where the N-substituted anion is fused to a benzene ring (?) to yield a '''enamine'''. See also [[Ethanamine]]. Note that the C=N double bond is the result (product) of asymmetric synthesis (Micheal addition) in presence of a organometal catalyst.  
+
* Question 1 : In your own words, explain at least 2 functions of the envZ/30C6HSL (ATP-dependent) synthetase in E. coli.
-
* assert biological relevance of Parkinson disease [2] as the result of prolonged 1,2,3,4-tetrahydroisoquinolines derivatives absorption: A 2-phenylmethylamine-specific enatiomer ?
+
* Question 2 : How is EnvZ relevant to CES (ADA) and specifically the CAMK2G gene?
-
* Additional data is provided in [http://brenda-enzymes.org/php/result_flat.php4?ecno=2.1.1.28&Suchword=&organism%5B%5D=Homo+sapiens&show_tm=0 EC 2.1.1.28] to confirm a solid link between Parkinson disease and novel tetrahydroisoquinolines derivatives. -- Check this. -[[User:Etienne_Robillard|ER]]
+
* Note: Further info on Phenylmethylamine substituted beta-amyloid ligands (APP) are [[User:Etienne_Robillard/Notebook/Phenylmethylamine|here]].
-
* tristable PD riboswitch abstrachachachatization: Check/verify the tri-stable RNA polymerase repressor functions (LuxR) and AHL evidences in the design of <font color="red">Schiff base conjugated C6 (hexanoyl) psychochemicals to induce (lazy) light-activated RNA transcription and metabolism</font>. -[[User:Etienne_Robillard|ER]]  
+
* Question 3 (bonus question) : In your own words, describe the role of a synthase enzyme (without the help of Wikipedia!) in the phosphorylation of ATP.
-
* Verify this lazy RNA polymerase function: 2ATP+CO2->Ph2CO<=>2(N+2(R)+OH) -[[User:Etienne_Robillard|ER]]
+
 
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=== Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl carbanion (4-substituted-7-aminoalkylamino-2,1,3-benzoxadiazoles) ===
 +
 
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* <font color=purple>For the long story, see [[User:Etienne_Robillard/Notebook/Phenylmethanamine|Phenylmethanamine]]: A nucleophilic Schiff base where the N-substituted anion is fused to a benzene ring (?) to yield a '''enamine'''. See also [[Ethanamine]]. Note that the C=N double bond is the result (product) of asymmetric synthesis (<font color="red">Micheal addition</font>) in presence of a organometal catalyst.</font> [[Image:500px-Diethyl cyanophosphate.svg.png|thumb|right|Example cyanophosphate-derived synthetic reagent. (PMID: 1818086, 15670935)]]
 +
** Assert biological relevance of Parkinson disease [2] as the result of prolonged 1,2,3,4-tetrahydroisoquinolines derivatives absorption: A 2-phenylmethylamine-specific enatiomer ?
 +
** Additional data is provided in [http://brenda-enzymes.org/php/result_flat.php4?ecno=2.1.1.28&Suchword=&organism%5B%5D=Homo+sapiens&show_tm=0 EC 2.1.1.28] to confirm a solid link between Parkinson disease and novel tetrahydroisoquinolines derivatives. -- Check this. -[[User:Etienne_Robillard|ER]]
 +
** tristable PD riboswitch abstrachachachatization: Check/verify the tri-stable mRNA polymerase repressor functions (LuxR) and AHL evidences in the design of <font color="red">Schiff base conjugated (6xHis tag) psychochemicals to induce (lazy) light-activated mRNA transcription and metabolism</font>. -[[User:Etienne_Robillard|ER]]  
 +
* Also Verify this lazy RNA polymerase function: 2ATP+CO2->Ph2CO<=>2(N+2(R)+OH) -[[User:Etienne_Robillard|ER]]
 +
* carbanion = cyanide anion
 +
* 6his-tag = a C6 hexanoyl based heterocyclic carbanion -- N-substituted oxazoles derivatives (imine)
 +
 
 +
=== The Monsanto connection: Troika acids; novel cyanophosphonate compounds as N-substituted (alkyl) drug carrier (pharmacochemical intermediates) ===
 +
* US6218563 (cyanophosphonamides as recombinant polyhistidine tag)
 +
* US5935542 (cyanophosphonate derivatives compounds as a n-substituted Schiff base) (ie: <font color=purple>for binding ca2+/mg2+ ions to a recombinant "fusion" protein...</font>)
 +
* Chuck: If you want to spray civilians without impunity, be sure to include a cyanoethyl moeity...
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* Oracle: Are you kidding? Once upon a time cyanide was at the basis of the Zyklon-b pellet...
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* Oracle: Hence, the magnitude and scale of civilians exposure to the new compound is probably most effective today.
 +
* Chuck: For next time, how about a ban of spraying civilians with pharmacochemical intermediates ?
 +
* Oracle: Go ask Obama!
 +
* Chuck: LOL
 +
* Oracle: Go ask Monsanto! When should it become natural to breath air ? Is this a luxury reserved for an elite golf club ?
 +
* Chuck: And Is this the reason I'm being emprisonned ?
 +
* Chuck: Because I refuse to happily breath such things while the majority of the breed have no clue what the heck a troika acid is composed of?
=== References ===
=== References ===
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# http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation
# http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation
# http://www.wikigenes.org/e/chem/e/7046.html
# http://www.wikigenes.org/e/chem/e/7046.html
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# DOI: 10.1021/ja00132a045
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 +
=== Did you know? ===
 +
 +
'"Attitude is a little thing that makes a big difference." - Winston Churchill

Revision as of 19:57, 11 April 2013

Contents

Introduction to Schiff bases

  • Insert text here in scientifically acceptable way (ie: without grammar errors) to explain the functions and basics of Schiff base formation. [1]

Schiff bases conjugated pharmacological intermediates and N-substituted heterocyclics carbenes

  • Present summarly the basic psychopharmacological aspects/functions of imine in a biological system .
    • pharmacological intermediates (N-substituted heterocyclics)
    • Nucleophilic carbonyl addition
    • PS: Yb(OTf)3 route to 1,2,3,4-tetrahydroisoquinolines derivatives.
    • Micheal addition=>PS (Pictet-Spengler asymmetric synthesis of 1,2,3,4-tetrahydroisoquinolines)

Schiff bases as quorum sensing molecules (AHL) and Serine-dependent osmolitic regulators/ATP synthase

  • Question 1 : In your own words, explain at least 2 functions of the envZ/30C6HSL (ATP-dependent) synthetase in E. coli.
  • Question 2 : How is EnvZ relevant to CES (ADA) and specifically the CAMK2G gene?
  • Note: Further info on Phenylmethylamine substituted beta-amyloid ligands (APP) are here.
  • Question 3 (bonus question) : In your own words, describe the role of a synthase enzyme (without the help of Wikipedia!) in the phosphorylation of ATP.

Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl carbanion (4-substituted-7-aminoalkylamino-2,1,3-benzoxadiazoles)

  • For the long story, see Phenylmethanamine: A nucleophilic Schiff base where the N-substituted anion is fused to a benzene ring (?) to yield a enamine. See also Ethanamine. Note that the C=N double bond is the result (product) of asymmetric synthesis (Micheal addition) in presence of a organometal catalyst.
    Example cyanophosphate-derived synthetic reagent. (PMID: 1818086, 15670935)
    Example cyanophosphate-derived synthetic reagent. (PMID: 1818086, 15670935)
    • Assert biological relevance of Parkinson disease [2] as the result of prolonged 1,2,3,4-tetrahydroisoquinolines derivatives absorption: A 2-phenylmethylamine-specific enatiomer ?
    • Additional data is provided in EC 2.1.1.28 to confirm a solid link between Parkinson disease and novel tetrahydroisoquinolines derivatives. -- Check this. -ER
    • tristable PD riboswitch abstrachachachatization: Check/verify the tri-stable mRNA polymerase repressor functions (LuxR) and AHL evidences in the design of Schiff base conjugated (6xHis tag) psychochemicals to induce (lazy) light-activated mRNA transcription and metabolism. -ER
  • Also Verify this lazy RNA polymerase function: 2ATP+CO2->Ph2CO<=>2(N+2(R)+OH) -ER
  • carbanion = cyanide anion
  • 6his-tag = a C6 hexanoyl based heterocyclic carbanion -- N-substituted oxazoles derivatives (imine)

The Monsanto connection: Troika acids; novel cyanophosphonate compounds as N-substituted (alkyl) drug carrier (pharmacochemical intermediates)

  • US6218563 (cyanophosphonamides as recombinant polyhistidine tag)
  • US5935542 (cyanophosphonate derivatives compounds as a n-substituted Schiff base) (ie: for binding ca2+/mg2+ ions to a recombinant "fusion" protein...)
  • Chuck: If you want to spray civilians without impunity, be sure to include a cyanoethyl moeity...
  • Oracle: Are you kidding? Once upon a time cyanide was at the basis of the Zyklon-b pellet...
  • Oracle: Hence, the magnitude and scale of civilians exposure to the new compound is probably most effective today.
  • Chuck: For next time, how about a ban of spraying civilians with pharmacochemical intermediates ?
  • Oracle: Go ask Obama!
  • Chuck: LOL
  • Oracle: Go ask Monsanto! When should it become natural to breath air ? Is this a luxury reserved for an elite golf club ?
  • Chuck: And Is this the reason I'm being emprisonned ?
  • Chuck: Because I refuse to happily breath such things while the majority of the breed have no clue what the heck a troika acid is composed of?

References

  1. http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation
  2. http://www.wikigenes.org/e/chem/e/7046.html
  3. DOI: 10.1021/ja00132a045

Did you know?

'"Attitude is a little thing that makes a big difference." - Winston Churchill

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