User:Tkadm30/Notebook/THC: Difference between revisions
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#Website3 http://www.thenakedscientists.com/forum/index.php?topic=65952.0 | #Website3 http://www.thenakedscientists.com/forum/index.php?topic=65952.0 | ||
#Website4 http://www.nature.com/articles/npjamd201612 | #Website4 http://www.nature.com/articles/npjamd201612 | ||
//Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids | |||
</biblio> | </biblio> | ||
===See also=== | ===See also=== | ||
* [[User:Etienne_Robillard/Notebook/TRPV1|TRPV1 Notebook]] | * [[User:Etienne_Robillard/Notebook/TRPV1|TRPV1 Notebook]] | ||
Revision as of 06:11, 1 July 2016
Synopsis
- Tetrahydrocannabinol (THC) is the main psychoactive constituent of Cannabis sativa L (Marijuana) plant.
- Other Marijuana compounds includes Cannabichromene (CBC), Cannabidiol (CBD), Cannabinol (CBN), Cannabigerol (CBG), Tetrahydrocannabivarin (THCV).
- Cannabis-derived cannabinoids are known as phytocannabinoids.
Antidepressant properties of THC
- THC stimulate anandamide biosynthesis by binding to the CB1 receptor, thus producing a antidepressant and neuroprotective effect. [1]
Neuroprotective properties of THC
- THC inhibit acetylcholinesterase (AChE)-induced intraneuronal amyloid beta aggregation in Alzheimer's disease: [2]
- THC prevent intracellular amyloid beta proteotoxicity and inflammatory response: http://www.nature.com/articles/npjamd201612
- THC as antiglutamatergic therapy for AChE-induced neurotoxicity. [3]
- Unlike THC, caffeine is a noncompetitive reversible inhibitor of AChE.
- THC reduce intraocular pressure (IOP) in retinal ganglion cells (RGCs) through intracellular CB1 receptor activation; A potential treatment for glaucoma to prevent optic nerve damage.
Proneurogenic effect of THC on neurogenesis
- Hippocampal CB1 receptors regulate stress-induced neuroinflammation in the hippocampus. [4]
- THC enhance adult hippocampal neurogenesis through intracellular CB1 receptor activation. [5][6]
- CB1 activation promote neuronal cell proliferation, differentiation, maturation, and neurite growth. [7]
Neuropsychology of THC tolerance
- CB1 receptor sensitization can be restored by taking breaks of oral THC administration, which stimulates endocannabinoid production. [8]
- Alcohol increase THC levels in blood.
Experimental
- Synaptogenic effect of THC/DHA promote hippocampal development (neurogenesis) and synaptogenesis.
- THC/DHA affect neural stem/progenitor cells (NS/PC) proliferation in the hippocampus.
References
-
Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L
- Eubanks LM, Rogers CJ, Beuscher AE 4th, Koob GF, Olson AJ, Dickerson TJ, and Janda KD. A molecular link between the active component of marijuana and Alzheimer's disease pathology. Mol Pharm. 2006 Nov-Dec;3(6):773-7. DOI:10.1021/mp060066m |
A molecular link between the active component of marijuana and Alzheimer's disease pathology.
- Pope C, Mechoulam R, and Parsons L. Endocannabinoid signaling in neurotoxicity and neuroprotection. Neurotoxicology. 2010 Sep;31(5):562-71. DOI:10.1016/j.neuro.2009.12.002 |
Endocannabinoid signaling in neurotoxicity and neuroprotection.
- Zoppi S, Pérez Nievas BG, Madrigal JL, Manzanares J, Leza JC, and García-Bueno B. Regulatory role of cannabinoid receptor 1 in stress-induced excitotoxicity and neuroinflammation. Neuropsychopharmacology. 2011 Mar;36(4):805-18. DOI:10.1038/npp.2010.214 |
Regulatory role of cannabinoid receptor 1 in stress-induced excitotoxicity and neuroinflammation.
- Jiang W, Zhang Y, Xiao L, Van Cleemput J, Ji SP, Bai G, and Zhang X. Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects. J Clin Invest. 2005 Nov;115(11):3104-16. DOI:10.1172/JCI25509 |
Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects.
- Campbell VA and Gowran A. Alzheimer's disease; taking the edge off with cannabinoids?. Br J Pharmacol. 2007 Nov;152(5):655-62. DOI:10.1038/sj.bjp.0707446 |
Alzheimer's disease; taking the edge off with cannabinoids?
- Xapelli S, Agasse F, Sardà-Arroyo L, Bernardino L, Santos T, Ribeiro FF, Valero J, Bragança J, Schitine C, de Melo Reis RA, Sebastião AM, and Malva JO. Activation of type 1 cannabinoid receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures. PLoS One. 2013;8(5):e63529. DOI:10.1371/journal.pone.0063529 |
Activation of type 1 cannabinoid receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures.
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Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids
