User:Tkadm30/Notebook/THC: Difference between revisions
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* Tetrahydrocannabinol (THC) is the main psychoactive constituent of Cannabis sativa L (Marijuana) plant. | * Tetrahydrocannabinol (THC) is the main psychoactive constituent of Cannabis sativa L (Marijuana) plant. | ||
* Other Marijuana compounds includes Cannabichromene (CBC), Cannabidiol (CBD), Cannabinol (CBN), and Cannabigerol (CBG). | * Other Marijuana compounds includes Cannabichromene (CBC), Cannabidiol (CBD), Cannabinol (CBN), and Cannabigerol (CBG). | ||
* Cannabis-derived cannabinoids are known as phytocannabinoids. | * Cannabis-derived cannabinoids are known as phytocannabinoids. | ||
* THC stimulate anandamide synthesis by binding to the CB1 receptor, thus producing a antidepressant and neuroprotective effect. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866040/ PMID] | * THC stimulate anandamide synthesis by binding to the CB1 receptor, thus producing a antidepressant and neuroprotective effect. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866040/ PMID] | ||
===Anticholinergic properties of THC=== | |||
* THC inhibit AChE-induced beta-amyloid aggregation in Alzheimer's disease: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562334/ PMID] | |||
* Anti-inflammatory activity of THC agaisnt organophosphate-induced neuroinflammation: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891218/ PMID] [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366364/ PMID] | |||
* Unlike THC, caffeine is a noncompetitive reversible inhibitor of AChE | |||
===THC effect on hippocampal neurogenesis=== | ===THC effect on hippocampal neurogenesis=== | ||
* Regulation of stress-induced neuroinflammation in the hippocampus. | * Regulation of stress-induced neuroinflammation in the hippocampus. | ||
Revision as of 04:57, 12 July 2015
- Tetrahydrocannabinol (THC) is the main psychoactive constituent of Cannabis sativa L (Marijuana) plant.
- Other Marijuana compounds includes Cannabichromene (CBC), Cannabidiol (CBD), Cannabinol (CBN), and Cannabigerol (CBG).
- Cannabis-derived cannabinoids are known as phytocannabinoids.
- THC stimulate anandamide synthesis by binding to the CB1 receptor, thus producing a antidepressant and neuroprotective effect. PMID
Anticholinergic properties of THC
- THC inhibit AChE-induced beta-amyloid aggregation in Alzheimer's disease: PMID
- Anti-inflammatory activity of THC agaisnt organophosphate-induced neuroinflammation: PMID PMID
- Unlike THC, caffeine is a noncompetitive reversible inhibitor of AChE
THC effect on hippocampal neurogenesis
- Regulation of stress-induced neuroinflammation in the hippocampus.
- Hippocampal neurogenesis is enhanced. PMID
Experimental
- Synaptogenic effect of Δ9-THC/DHEA ligands promote hippocampal development.
- Δ9-THC/DHEA ligands (synaptamide) affect neural stem/progenitor cells (NS/PC) proliferation in the hippocampus.
