User:Tkadm30/Notebook/THC: Difference between revisions
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===Experimental=== | ===Experimental=== | ||
* Synaptogenic effect of | * Synaptogenic effect of THC/DHA promote hippocampal development (neurogenesis) and synaptogenesis. | ||
* | * THC/DHA affect neural stem/progenitor cells (NS/PC) proliferation in the hippocampus. | ||
===References=== | ===References=== | ||
<biblio> | <biblio> | ||
Revision as of 06:25, 16 November 2015
Synopsis
- Tetrahydrocannabinol (THC) is the main psychoactive constituent of Cannabis sativa L (Marijuana) plant.
- Other Marijuana compounds includes Cannabichromene (CBC), Cannabidiol (CBD), Cannabinol (CBN), and Cannabigerol (CBG).
- Cannabis-derived cannabinoids are known as phytocannabinoids.
Antidepressant properties of THC
- THC stimulate anandamide biosynthesis by binding to the CB1 receptor, thus producing a antidepressant and neuroprotective effect. [1]
Neuroprotective properties of THC
- THC inhibit acetylcholinesterase (AChE)-induced beta-amyloid aggregation in Alzheimer's disease: [2]
- THC as antiglutamatergic therapy for AChE-induced neurotoxicity. [3]
- Unlike THC, caffeine is a noncompetitive reversible inhibitor of AChE.
Proneurogenic effect of THC on neurogenesis
- Regulation of stress-induced neuroinflammation in the hippocampus.
- THC enhance hippocampal neurogenesis through CB1 receptor activation. [4][5]
- CB1 activation promote neuronal cell proliferation, differentiation, maturation, and neurite growth. [6]
Experimental
- Synaptogenic effect of THC/DHA promote hippocampal development (neurogenesis) and synaptogenesis.
- THC/DHA affect neural stem/progenitor cells (NS/PC) proliferation in the hippocampus.
References
- Eubanks LM, Rogers CJ, Beuscher AE 4th, Koob GF, Olson AJ, Dickerson TJ, and Janda KD. A molecular link between the active component of marijuana and Alzheimer's disease pathology. Mol Pharm. 2006 Nov-Dec;3(6):773-7. DOI:10.1021/mp060066m |
A molecular link between the active component of marijuana and Alzheimer's disease pathology.
- Pope C, Mechoulam R, and Parsons L. Endocannabinoid signaling in neurotoxicity and neuroprotection. Neurotoxicology. 2010 Sep;31(5):562-71. DOI:10.1016/j.neuro.2009.12.002 |
Endocannabinoid signaling in neurotoxicity and neuroprotection.
- Jiang W, Zhang Y, Xiao L, Van Cleemput J, Ji SP, Bai G, and Zhang X. Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects. J Clin Invest. 2005 Nov;115(11):3104-16. DOI:10.1172/JCI25509 |
Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects.
- Campbell VA and Gowran A. Alzheimer's disease; taking the edge off with cannabinoids?. Br J Pharmacol. 2007 Nov;152(5):655-62. DOI:10.1038/sj.bjp.0707446 |
Alzheimer's disease; taking the edge off with cannabinoids?
- Xapelli S, Agasse F, Sardà-Arroyo L, Bernardino L, Santos T, Ribeiro FF, Valero J, Bragança J, Schitine C, de Melo Reis RA, Sebastião AM, and Malva JO. Activation of type 1 cannabinoid receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures. PLoS One. 2013;8(5):e63529. DOI:10.1371/journal.pone.0063529 |
Activation of type 1 cannabinoid receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures.
