User:Tkadm30/Notebook/THC: Difference between revisions

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Sweet Marijane,
__TOC__
===Synopsis===
* Tetrahydrocannabinol (THC) is the main psychoactive constituent of Cannabis sativa L (Marijuana) plant.
* Other Marijuana compounds includes Cannabichromene (CBC), Cannabidiol (CBD), Cannabinol (CBN), Cannabigerol (CBG), Tetrahydrocannabivarin (THCV).
* Cannabis-derived cannabinoids are known as phytocannabinoids.


Before the dawn of ages you have cured the afflicted from mental oppression,
===Antidepressant properties of THC===
* THC stimulate anandamide biosynthesis by binding to the CB1 receptor, thus producing a antidepressant and neuroprotective effect. <cite>Website2</cite>


We have learned to cultivate you  even you were repressed from repressors of the truth,
===Neuroprotective properties of THC===
* THC inhibit acetylcholinesterase (AChE)-induced intraneuronal amyloid beta aggregation in Alzheimer's disease: <cite>Eubanks-2006</cite>
** THC prevent intracellular amyloid beta proteotoxicity and inflammatory response: <cite>Website4</cite>
* THC is effective as antiglutamatergic therapy for NMDA-induced excitotoxicity. <cite>Pope-2010</cite>
* Unlike THC, caffeine is a noncompetitive reversible inhibitor of AChE.
* THC reduce intraocular pressure (IOP) in retinal ganglion cells (RGCs) through intracellular CB1 receptor activation; A potential treatment for glaucoma to prevent optic nerve damage.


We have tried to make you appear as a sickeness for the weaken, but you were our reason for hope and justice,
===Proneurogenic effects of THC on neurogenesis and BDNF signaling===
* Hippocampal CB1 receptors regulate stress-induced neuroinflammation in the hippocampus. <cite>Zoppi-2011</cite>
* THC enhance adult hippocampal neurogenesis and BDNF signaling through intracellular CB1 receptor activation. <cite>Jiang-2005</cite><cite>Campbell-2007</cite>
* Intracellular CB1 activation promote neuronal cell proliferation, differentiation, maturation, and neurite growth. <cite>Xapelli-2013</cite>


To prevail on us,
===Neuropsychology of THC tolerance===
* CB1 receptor sensitization can be restored by taking breaks of oral THC administration, which stimulates endocannabinoid production. <cite>Website3</cite>
* Alcohol increase THC levels in blood.


We have ridiculized you as a gateway drug for ridiculous reasons, and you were none of that,
===Experimental===
* Synaptogenic effect of THC/DHA promote hippocampal development (neurogenesis) and synaptogenesis.
* THC/DHA affect neural stem/progenitor cells (NS/PC) proliferation in the hippocampus.


We have guessed on your origins blindly, yet poorly aware of the [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165946/ science] which you draw your benefits and love for us,
===References===
<biblio>
#Eubanks-2006 pmid=17140265
//A molecular link between the active component of marijuana and Alzheimer's disease pathology.
#Pope-2010 pmid=19969019
//Endocannabinoid signaling in neurotoxicity and neuroprotection.
#Jiang-2005 pmid=16224541
//Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects.
#Campbell-2007 pmid=17828287
//Alzheimer's disease; taking the edge off with cannabinoids?
#Xapelli-2013 pmid=23704915
//Activation of type 1 cannabinoid receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures.
#Zoppi-2011 pmid=21150911
//Regulatory role of cannabinoid receptor 1 in stress-induced excitotoxicity and neuroinflammation.
#Website1 https://en.wikipedia.org/wiki/Cannabinoid
#Website2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866040/
//Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L
#Website3 http://www.thenakedscientists.com/forum/index.php?topic=65952.0
#Website4 http://www.nature.com/articles/npjamd201612
//Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids
</biblio>


We try to commit you in illegal prohibition and traffic, but you still growing silently,
===See also===
 
* [[User:Etienne_Robillard/Notebook/TRPV1|TRPV1 Notebook]]
You were equally refusing to listen to the voices of oppression and resisting to moths,
 
And I love you for that,
 
My Dear Sweet Marijane,
 
Let your roots become a source of inspiration for thoses who seek the truth and recomfort in your love!
 
----
 
[[User:Etienne Robillard|Etienne Robillard]] 11:58, 28 January 2013 (EST)

Revision as of 05:02, 31 October 2016

Synopsis

  • Tetrahydrocannabinol (THC) is the main psychoactive constituent of Cannabis sativa L (Marijuana) plant.
  • Other Marijuana compounds includes Cannabichromene (CBC), Cannabidiol (CBD), Cannabinol (CBN), Cannabigerol (CBG), Tetrahydrocannabivarin (THCV).
  • Cannabis-derived cannabinoids are known as phytocannabinoids.

Antidepressant properties of THC

  • THC stimulate anandamide biosynthesis by binding to the CB1 receptor, thus producing a antidepressant and neuroprotective effect. [1]

Neuroprotective properties of THC

  • THC inhibit acetylcholinesterase (AChE)-induced intraneuronal amyloid beta aggregation in Alzheimer's disease: [2]
    • THC prevent intracellular amyloid beta proteotoxicity and inflammatory response: [3]
  • THC is effective as antiglutamatergic therapy for NMDA-induced excitotoxicity. [4]
  • Unlike THC, caffeine is a noncompetitive reversible inhibitor of AChE.
  • THC reduce intraocular pressure (IOP) in retinal ganglion cells (RGCs) through intracellular CB1 receptor activation; A potential treatment for glaucoma to prevent optic nerve damage.

Proneurogenic effects of THC on neurogenesis and BDNF signaling

  • Hippocampal CB1 receptors regulate stress-induced neuroinflammation in the hippocampus. [5]
  • THC enhance adult hippocampal neurogenesis and BDNF signaling through intracellular CB1 receptor activation. [6][7]
  • Intracellular CB1 activation promote neuronal cell proliferation, differentiation, maturation, and neurite growth. [8]

Neuropsychology of THC tolerance

  • CB1 receptor sensitization can be restored by taking breaks of oral THC administration, which stimulates endocannabinoid production. [9]
  • Alcohol increase THC levels in blood.

Experimental

  • Synaptogenic effect of THC/DHA promote hippocampal development (neurogenesis) and synaptogenesis.
  • THC/DHA affect neural stem/progenitor cells (NS/PC) proliferation in the hippocampus.

References

  1. [Website2]

    Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L

  2. Eubanks LM, Rogers CJ, Beuscher AE 4th, Koob GF, Olson AJ, Dickerson TJ, and Janda KD. A molecular link between the active component of marijuana and Alzheimer's disease pathology. Mol Pharm. 2006 Nov-Dec;3(6):773-7. DOI:10.1021/mp060066m | PubMed ID:17140265 | HubMed [Eubanks-2006]

    A molecular link between the active component of marijuana and Alzheimer's disease pathology.

  3. [Website4]

    Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids

  4. Pope C, Mechoulam R, and Parsons L. Endocannabinoid signaling in neurotoxicity and neuroprotection. Neurotoxicology. 2010 Sep;31(5):562-71. DOI:10.1016/j.neuro.2009.12.002 | PubMed ID:19969019 | HubMed [Pope-2010]

    Endocannabinoid signaling in neurotoxicity and neuroprotection.

  5. Zoppi S, Pérez Nievas BG, Madrigal JL, Manzanares J, Leza JC, and García-Bueno B. Regulatory role of cannabinoid receptor 1 in stress-induced excitotoxicity and neuroinflammation. Neuropsychopharmacology. 2011 Mar;36(4):805-18. DOI:10.1038/npp.2010.214 | PubMed ID:21150911 | HubMed [Zoppi-2011]

    Regulatory role of cannabinoid receptor 1 in stress-induced excitotoxicity and neuroinflammation.

  6. Jiang W, Zhang Y, Xiao L, Van Cleemput J, Ji SP, Bai G, and Zhang X. Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects. J Clin Invest. 2005 Nov;115(11):3104-16. DOI:10.1172/JCI25509 | PubMed ID:16224541 | HubMed [Jiang-2005]

    Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects.

  7. Campbell VA and Gowran A. Alzheimer's disease; taking the edge off with cannabinoids?. Br J Pharmacol. 2007 Nov;152(5):655-62. DOI:10.1038/sj.bjp.0707446 | PubMed ID:17828287 | HubMed [Campbell-2007]

    Alzheimer's disease; taking the edge off with cannabinoids?

  8. Xapelli S, Agasse F, Sardà-Arroyo L, Bernardino L, Santos T, Ribeiro FF, Valero J, Bragança J, Schitine C, de Melo Reis RA, Sebastião AM, and Malva JO. Activation of type 1 cannabinoid receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures. PLoS One. 2013;8(5):e63529. DOI:10.1371/journal.pone.0063529 | PubMed ID:23704915 | HubMed [Xapelli-2013]

    Activation of type 1 cannabinoid receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures.

  9. [Website3]
  10. [Website1]

All Medline abstracts: PubMed | HubMed

See also