User:Tkadm30/Notebook/THC: Difference between revisions
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===THC effect on hippocampal neurogenesis=== | ===THC effect on hippocampal neurogenesis=== | ||
* Regulation of stress-induced neuroinflammation in the hippocampus. | * Regulation of stress-induced neuroinflammation in the hippocampus. | ||
* Hippocampal neurogenesis is enhanced. [ | * Hippocampal neurogenesis is enhanced. [https://www.ncbi.nlm.nih.gov/pubmed/16224541/ PMID] | ||
===Experimental=== | ===Experimental=== | ||
* Synaptogenic effect of Δ9-THC/DHEA ligands promote hippocampal development. | * Synaptogenic effect of Δ9-THC/DHEA ligands promote hippocampal development. | ||
Revision as of 05:00, 12 July 2015
- Tetrahydrocannabinol (THC) is the main psychoactive constituent of Cannabis sativa L (Marijuana) plant.
- Other Marijuana compounds includes Cannabichromene (CBC), Cannabidiol (CBD), Cannabinol (CBN), and Cannabigerol (CBG).
- Cannabis-derived cannabinoids are known as phytocannabinoids.
- THC stimulate anandamide synthesis by binding to the CB1 receptor, thus producing a antidepressant and neuroprotective effect. PMID
Anticholinergic properties of THC
- THC inhibit AChE-induced beta-amyloid aggregation in Alzheimer's disease: PMID
- Anti-inflammatory activity of THC agaisnt organophosphate-induced neuroinflammation: PMID PMID
- Unlike THC, caffeine is a noncompetitive reversible inhibitor of AChE
THC effect on hippocampal neurogenesis
- Regulation of stress-induced neuroinflammation in the hippocampus.
- Hippocampal neurogenesis is enhanced. PMID
Experimental
- Synaptogenic effect of Δ9-THC/DHEA ligands promote hippocampal development.
- Δ9-THC/DHEA ligands (synaptamide) affect neural stem/progenitor cells (NS/PC) proliferation in the hippocampus.
