User:Tkadm30/Notebook/THC

Synopsis

• Tetrahydrocannabinol (THC) is the main psychoactive constituent of Cannabis sativa L (Marijuana) plant.
• Other Marijuana compounds includes Cannabichromene (CBC), Cannabidiol (CBD), Cannabinol (CBN), and Cannabigerol (CBG).
• Cannabis-derived cannabinoids are known as phytocannabinoids.
• THC stimulate anandamide biosynthesis by binding to the CB1 receptor, thus producing a antidepressant and neuroprotective effect. PMID PMID

Anticholinergic properties of THC

• THC inhibit anticholinesterase (AChE) induced beta-amyloid aggregation in Alzheimer's disease: PMID
• THC as antiglutamatergic therapy for AChE induced neurotoxicity: PMID PMID PMID
• Unlike THC, caffeine is a noncompetitive reversible inhibitor of AChE

Proneurogenic effect of THC on neurogenesis

• Regulation of stress-induced neuroinflammation in the hippocampus.
• Hippocampal neurogenesis is enhanced. PMID PMID
• CB1 activation promote neuronal cell proliferation, differentiation, maturation, and neurite growth. PMID

Experimental

• Synaptogenic effect of Δ9-THC/DHEA ligands promote hippocampal development.
• Δ9-THC/DHEA ligands (synaptamide) affect neural stem/progenitor cells (NS/PC) proliferation in the hippocampus.

References

1. https://en.wikipedia.org/wiki/Cannabinoid

2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866040/

See also

• TRPV1 Notebook