User:Tkadm30/Notebook/THC

Synopsis

• Tetrahydrocannabinol (THC) is the main psychoactive constituent of Cannabis sativa L (Marijuana) plant.
• Other Marijuana compounds includes Cannabichromene (CBC), Cannabidiol (CBD), Cannabinol (CBN), and Cannabigerol (CBG).
• Cannabis-derived cannabinoids are known as phytocannabinoids.
• THC stimulate anandamide biosynthesis by binding to the CB1 receptor, thus producing a antidepressant and neuroprotective effect. [1]

Anticholinergic properties of THC

• THC inhibit anticholinesterase (AChE) induced beta-amyloid aggregation in Alzheimer's disease: [2]
• THC as antiglutamatergic therapy for AChE induced neurotoxicity. [3]
• Unlike THC, caffeine is a noncompetitive reversible inhibitor of AChE

Proneurogenic effect of THC on neurogenesis

• Regulation of stress-induced neuroinflammation in the hippocampus.
• Hippocampal neurogenesis is enhanced. PMID PMID
• CB1 activation promote neuronal cell proliferation, differentiation, maturation, and neurite growth. PMID

Experimental

• Synaptogenic effect of Δ9-THC/DHEA ligands promote hippocampal development.
• Δ9-THC/DHEA ligands (synaptamide) affect neural stem/progenitor cells (NS/PC) proliferation in the hippocampus.

References

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866040/

2. Eubanks LM, Rogers CJ, Beuscher AE 4th, Koob GF, Olson AJ, Dickerson TJ, and Janda KD. A molecular link between the active component of marijuana and Alzheimer's disease pathology. Mol Pharm. 2006 Nov-Dec;3(6):773-7. DOI:10.1021/mp060066m |

   A molecular link between the active component of marijuana and Alzheimer's disease pathology.

3. Pope C, Mechoulam R, and Parsons L. Endocannabinoid signaling in neurotoxicity and neuroprotection. Neurotoxicology. 2010 Sep;31(5):562-71. DOI:10.1016/j.neuro.2009.12.002 |

   Endocannabinoid signaling in neurotoxicity and neuroprotection.

4. https://en.wikipedia.org/wiki/Cannabinoid

See also

• TRPV1 Notebook