User:Tkadm30/Notebook/chim trills notebook: Difference between revisions
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== Hypothesis == | == Hypothesis == | ||
1. The | 1. The molecular toxicity of aerosolized nanoparticles (PM2.5) is poorly understood. | ||
2. The | 2. The nanotoxicity of stratospheric aerosol injections (SAI) on human health requires further investigations. | ||
3. The differential effects of highly dispersed aerosols (HDA) on the neuroimmune system, lung | 3. The differential effects of highly dispersed aerosols (HDA) on the neuroimmune system, lung/brain axis, chronic inflammation, and neurodegenerative disorders (Alzheimer, Parkinson) requires additional research. <cite>Gilmour-2004</cite> | ||
4. | 4. MAC1 activation is implicated in the dopaminergic-mediated neurotoxicity of aerosolized nanoparticles. <cite>Levesque-2013</cite> | ||
== Differential effects of | == Differential effects of nanoparticles translocation == | ||
=== Cardiovascular system === | === Cardiovascular system === | ||
* Effects of particulate matter (PM2.5) air pollution on cardiovascular disease <cite>Brook-2010</cite> | * Effects of particulate matter (PM2.5) air pollution on cardiovascular disease <cite>Brook-2010</cite> | ||
** Increase in blood pressure <cite>Balasubramanian-2013</cite> | ** Increase in blood pressure (hypertension) <cite>Balasubramanian-2013</cite> | ||
=== Central nervous system === | === Central nervous system === | ||
* Alzheimer disease <cite>Jung-2015</cite><cite>Levesque-2013</cite> | * Alzheimer disease <cite>Jung-2015</cite><cite>Levesque-2013</cite> | ||
* Parkinson disease <cite>Levesque-2013</cite> | * Parkinson disease <cite>Levesque-2013</cite> | ||
* PM2.5 exposure may cause chronic neuroinflammation and oxidative stress. <cite>Lei-2015</cite><cite>Liu-2015</cite><cite>Riva-2011</cite><cite>Levesque-2011</cite> | * PM2.5 exposure may cause chronic neuroinflammation and oxidative stress. <cite>Lei-2015</cite><cite>Liu-2015</cite><cite>Riva-2011</cite><cite>Levesque-2011</cite> | ||
* PM2.5 exposure may induce selective neurotoxicity through glutamatergic signaling and increase NMDA-induced excitotoxicity. <cite>Liu-2015</cite><cite>Morgan-2011</cite> | |||
* Cyclooxygenase-2, interleukin-1beta, and CD14 signaling upregulation. <cite>Solt-2008</cite> | * Cyclooxygenase-2, interleukin-1beta, and CD14 signaling upregulation. <cite>Solt-2008</cite> | ||
* Microglia-mediated dopaminergic neurotoxicity (Reactive microgliosis). <cite>Levesque-2013</cite> | * Microglia-mediated dopaminergic neurotoxicity (Reactive microgliosis). <cite>Levesque-2013</cite> | ||
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* Decrease of serum testosterone levels <cite>Lavicoli-2013</cite> | * Decrease of serum testosterone levels <cite>Lavicoli-2013</cite> | ||
* Increase of serum estradiol levels <cite>Lavicoli-2013</cite> | * Increase of serum estradiol levels <cite>Lavicoli-2013</cite> | ||
* Chronic fatigue syndrome (CFS) | |||
=== Lymphatic system === | === Lymphatic system === | ||
* Lipid peroxidation and oxidative DNA damage. <cite>Ambroz-2016</cite> | * Lipid peroxidation and oxidative DNA/RNA damage. <cite>Ambroz-2016</cite> | ||
=== Respiratory system === | === Respiratory system === | ||
* AECOPD <cite>Lei-2015</cite> | * AECOPD <cite>Lei-2015</cite> | ||
* Lung cancer <cite>Hamra-2014</cite> | * Lung cancer <cite>Hamra-2014</cite> | ||
== | == Nanotoxicity of aerosolized nanoparticles == | ||
* | * [[User:Etienne_Robillard/Notebook/chim_trills_notebook/2014/12/14|Notebook]] | ||
== Notes == | == Notes == | ||
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** [http://www.thenakedscientists.com/forum/index.php?topic=68004 Do coal-based jet fuel (JP-900) emit ultrafine particles?] | ** [http://www.thenakedscientists.com/forum/index.php?topic=68004 Do coal-based jet fuel (JP-900) emit ultrafine particles?] | ||
** [http://www.thenakedscientists.com/forum/index.php?topic=67942 Is coal fly ash a synthetic compound?] | ** [http://www.thenakedscientists.com/forum/index.php?topic=67942 Is coal fly ash a synthetic compound?] | ||
** [http://www.thenakedscientists.com/forum/index.php?topic=68555 Is reactive microgliosis a beneficial or harmful process?] | |||
** [http://www.thenakedscientists.com/forum/index.php?topic=67302 Should we ban geoengineering?] | ** [http://www.thenakedscientists.com/forum/index.php?topic=67302 Should we ban geoengineering?] | ||
** [http://www.thenakedscientists.com/forum/index.php?topic=68061 What is the Gulf War syndrome?] | ** [http://www.thenakedscientists.com/forum/index.php?topic=68061 What is the Gulf War syndrome?] | ||
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== Keywords == | == Keywords == | ||
aerosol, bioaerosol, nanoparticles, aluminium oxide, particulate matter, PM2.5, gulf war syndrome, chronic neuroinflammation, vapor phase oxidation, hydrocarbons, barium hexaaluminate, microglia, MAC1 | |||
aerosol, bioaerosol, nanoparticles, aluminium oxide, particulate matter, PM2.5 | |||
== Support this project == | == Support this project == | ||
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#Herndon-2016 http://nuclearplanet.com/frontiers1.pdf | #Herndon-2016 http://nuclearplanet.com/frontiers1.pdf | ||
//Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification. | //Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification. | ||
#Gilmour-2004 | #Gilmour-2004 https://www.ncbi.nlm.nih.gov/pubmed/15061611 | ||
//Differential pulmonary inflammation and in vitro cytotoxicity of size-fractionated fly ash particles from pulverized coal combustion. | //Differential pulmonary inflammation and in vitro cytotoxicity of size-fractionated fly ash particles from pulverized coal combustion. | ||
#Brook-2010 | #Brook-2010 https://www.ncbi.nlm.nih.gov/pubmed/20458016 | ||
//Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. | //Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. | ||
#Jung-2015 | #Jung-2015 https://www.ncbi.nlm.nih.gov/pubmed/25310992 | ||
//Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan. | //Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan. | ||
#Lei-2015 http://journal.frontiersin.org/article/10.3389/fphys.2015.00294/full | #Lei-2015 http://journal.frontiersin.org/article/10.3389/fphys.2015.00294/full | ||
//Fine particulate matter in acute exacerbation of COPD. | //Fine particulate matter in acute exacerbation of COPD. | ||
#Hamra-2014 | #Hamra-2014 https://www.ncbi.nlm.nih.gov/pubmed/24911630 | ||
//Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis. | //Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis. | ||
#Liu-2015 | #Liu-2015 https://www.ncbi.nlm.nih.gov/pubmed/25913161 | ||
//Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation. | //Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation. | ||
#Riva-2011 | #Riva-2011 https://www.ncbi.nlm.nih.gov/pubmed/21506876 | ||
//Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice. | //Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice. | ||
#Levesque-2011 | #Levesque-2011 https://www.ncbi.nlm.nih.gov/pubmed/21561831 | ||
//Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity. | //Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity. | ||
#Morgan-2011 | #Morgan-2011 https://www.ncbi.nlm.nih.gov/pubmed/21724521 | ||
//Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro. | //Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro. | ||
#Cheng-2010 http://www.tandfonline.com/doi/abs/10.1080/027868201753306714 | #Cheng-2010 http://www.tandfonline.com/doi/abs/10.1080/027868201753306714 | ||
//Chemical Composition of Aerosols from Kerosene Heaters Burning Jet Fuels. | //Chemical Composition of Aerosols from Kerosene Heaters Burning Jet Fuels. | ||
#Ambroz-2016 | #Ambroz-2016 https://www.ncbi.nlm.nih.gov/pubmed/27321041 | ||
//Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns. | //Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns. | ||
#Balasubramanian-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402685/ | #Balasubramanian-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402685/ | ||
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#Lavicoli-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759935/ | #Lavicoli-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759935/ | ||
//The Effects of Nanomaterials as Endocrine Disruptors. | //The Effects of Nanomaterials as Endocrine Disruptors. | ||
#Solt-2008 | #Solt-2008 https://www.ncbi.nlm.nih.gov/pubmed/18349428 | ||
//Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults. | //Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults. | ||
#Levesque-2013 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660420/ | #Levesque-2013 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660420/ | ||
Revision as of 14:06, 18 November 2016
Work-in-progress. Please correct any errors found.
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Hypothesis1. The molecular toxicity of aerosolized nanoparticles (PM2.5) is poorly understood. 2. The nanotoxicity of stratospheric aerosol injections (SAI) on human health requires further investigations. 3. The differential effects of highly dispersed aerosols (HDA) on the neuroimmune system, lung/brain axis, chronic inflammation, and neurodegenerative disorders (Alzheimer, Parkinson) requires additional research. [1] 4. MAC1 activation is implicated in the dopaminergic-mediated neurotoxicity of aerosolized nanoparticles. [2] Differential effects of nanoparticles translocationCardiovascular system
Central nervous system
Endocrine system
Lymphatic system
Respiratory systemNanotoxicity of aerosolized nanoparticlesNotes
ResourcesKeywordsaerosol, bioaerosol, nanoparticles, aluminium oxide, particulate matter, PM2.5, gulf war syndrome, chronic neuroinflammation, vapor phase oxidation, hydrocarbons, barium hexaaluminate, microglia, MAC1 Support this projectThis project is entirely financed by personal donations. To support this project, use the following link to donate money via Paypal: https://paypal.me/EtienneRobillard References
LicenseCopyright (C) 2012-2016 Etienne Robillard Permission is granted to copy, distribute and/or modify this document Under the terms of the GNU Free Documentation License, Version 1.3 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled "GNU Free Documentation License".
See you in space cowboy
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