User:Tkadm30/Notebook/chim trills notebook: Difference between revisions

From OpenWetWare
Jump to navigationJump to search
(90 intermediate revisions by the same user not shown)
Line 20: Line 20:


== Hypothesis ==
== Hypothesis ==
The biological functions of clandestine geoengineering activity are poorly understood. The effects of stratospheric aerosol injection on public health require further investigations. In particular, the effects of highly dispersed aerosols (HDA) on lung function, pulmonary inflammation and cancer pathogenesis may require additional research. <cite>Gilmour-2004</cite>
1. Unilateral/clandestine geoengineering activity is a source of air pollution. ('''PM2.5''')


== Clinical effects of clandestine geoengineering activity ==
2. The molecular toxicity of PM2.5 is poorly understood.
=== Genotoxicity ===
 
* [http://openwetware.org/wiki/User:Etienne_Robillard/Notebook/Brainstorming#Genotoxicity_of_coal_fly_ash_nanoparticles Genotoxicity of coal fly ash nanoparticles]
3. The nanotoxicity of PM2.5 on human health requires further investigations.
* Lung cancer <cite>Hamra-2014</cite>
 
4. The differential effects of PM2.5 on the neuroimmune system, lung/brain axis, chronic inflammation, and neurodegenerative disorders (Alzheimer, Parkinson) requires additional research. <cite>Gilmour-2004</cite>
 
5. MAC1 activation is implicated in the dopaminergic-mediated neurotoxicity of PM2.5. <cite>Levesque-2013</cite>


== Differential effects of nanoparticles translocation ==
=== Cardiovascular system ===
=== Cardiovascular system ===
* Effects of particulate matter (PM) air pollution on cardiovascular disease <cite>Brook-2010</cite>
* Effects of particulate matter (PM2.5) air pollution on cardiovascular disease <cite>Brook-2010</cite>
** Increase in blood pressure (hypertension) <cite>Balasubramanian-2013</cite>
 
=== Central nervous system ===
* Alzheimer disease <cite>Jung-2015</cite><cite>Levesque-2013</cite>
* Parkinson disease <cite>Levesque-2013</cite>
* PM2.5 exposure may cause chronic neuroinflammation and oxidative stress. <cite>Lei-2015</cite><cite>Liu-2015</cite><cite>Riva-2011</cite><cite>Levesque-2011</cite>
* PM2.5 exposure may induce selective neurotoxicity through glutamatergic signaling and increase NMDA-induced excitotoxicity. <cite>Liu-2015</cite><cite>Morgan-2011</cite>
* Cyclooxygenase-2, interleukin-1beta, and CD14 signaling upregulation. <cite>Solt-2008</cite>
* Microglia-mediated dopaminergic neurotoxicity (Reactive microgliosis). <cite>Levesque-2013</cite>
 
=== Endocrine system ===
* Decrease of serum testosterone levels <cite>Lavicoli-2013</cite>
* Increase of serum estradiol levels <cite>Lavicoli-2013</cite>
* Chronic fatigue syndrome (CFS)
 
=== Lymphatic system ===
* Lipid peroxidation and oxidative DNA/RNA damage. <cite>Ambroz-2016</cite>
 
=== Respiratory system ===
* AECOPD <cite>Lei-2015</cite>
* AECOPD <cite>Lei-2015</cite>
* Lung cancer <cite>Hamra-2014</cite>


=== Brain/CNS ===
== Nanotoxicity of aerosolized nanoparticles ==
* Particulate matter (PM2.5) exposure may cause neuroinflammation and oxidative stress. <cite>Lei-2015</cite><cite>Liu-2015</cite><cite>Riva-2011</cite><cite>Levesque-2011</cite>
* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/2014/12/14|Notebook]]
* Alzheimer <cite>Jung-2015</cite>
* PM2.5 exposure induce selective neurotoxicity through glutamatergic signaling. <cite>Liu-2015</cite>
 
== Cognitive infiltration evidences ==
* Facebook Deception: [[User:Etienne_Robillard/Notebook/chim_trills_notebook/2014/12/14|Notebook]]


== Notes ==
== Notes ==
* [http://www.thenakedscientists.com/forum/index.php?topic=67942 Is coal fly ash a synthetic compound?]
* Aerosolized nanoparticles:
** [http://www.energy.psu.edu/sites/default/files/files/JetFuels.pdf Advanced Thermally Stable Jet Fuels]
** [http://www.energy.psu.edu/sites/default/files/files/coalbased_jetfuel.pdf The Coal-Based Jet Fuel Program]
** [http://web.stanford.edu/group/pitsch/publication/ColketJet_Fuel_Surrogate_AIAA_2007.pdf Jet Fuel Surrogate Research]
** [https://dspace.mit.edu/handle/1721.1/9116 Catalytic combustion of methane with nanostructured barium hexaaluminate-based materials]
* Discussion:
** [http://www.thenakedscientists.com/forum/index.php?topic=68004 Do coal-based jet fuel (JP-900) emit ultrafine particles?]
** [http://www.thenakedscientists.com/forum/index.php?topic=67942 Is coal fly ash a synthetic compound?]
** [http://www.thenakedscientists.com/forum/index.php?topic=68555 Is reactive microgliosis a beneficial or harmful process?]
** [http://www.thenakedscientists.com/forum/index.php?topic=67302 Should we ban geoengineering?]
** [http://www.thenakedscientists.com/forum/index.php?topic=68061 What is the Gulf War syndrome?]
** [http://www.thenakedscientists.com/forum/index.php?topic=68101 What is a jet fuel surrogate?]
* Documentation:
** [https://en.wikipedia.org/wiki/Dodecane Dodecane (Wikipedia)]
** [https://en.wikipedia.org/wiki/Ethylbenzene Ethylbenzene (Wikipedia)]
** [http://www.ncbi.nlm.nih.gov/gene/2744 Glutaminase]
** [http://www.ncbi.nlm.nih.gov/pubmed/?term=gulf+war+syndrome Gulf War syndrome (PubMed search)]
** [https://en.wikipedia.org/wiki/Gulf_War_syndrome Gulf War syndrome (Wikipedia)]
** [https://en.wikipedia.org/wiki/Methylcyclohexane Methylcyclohexane (Wikipedia)]


== Resources ==
== Resources ==
Line 50: Line 87:


== Keywords ==
== Keywords ==
aerosol, bioaerosol, nanoparticles, aluminium oxide, particulate matter, PM2.5, gulf war syndrome, chronic neuroinflammation, vapor phase oxidation, hydrocarbons, barium, microglia, MAC1
== Support this project ==


coal fly ash, aerosol, bioaerosol, nanoparticles, aluminium, particulate matter, PM2.5
This project is entirely financed by personal donations. To support this project, use the following link
to donate money via Paypal: https://paypal.me/EtienneRobillard


== References ==
== References ==
Line 57: Line 98:
#Herndon-2015 http://www.mdpi.com/1660-4601/12/8/9375/htm
#Herndon-2015 http://www.mdpi.com/1660-4601/12/8/9375/htm
//Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health
//Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health
#Herndon-2016 pmid=27433467
#Herndon-2016 http://nuclearplanet.com/frontiers1.pdf
//Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification.
//Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification.
#Gilmour-2004 pmid=15061611
#Gilmour-2004 https://www.ncbi.nlm.nih.gov/pubmed/15061611
//Differential pulmonary inflammation and in vitro cytotoxicity of size-fractionated fly ash particles from pulverized coal combustion.
//Differential pulmonary inflammation and in vitro cytotoxicity of size-fractionated fly ash particles from pulverized coal combustion.
#Brook-2010 pmid=20458016
#Brook-2010 https://www.ncbi.nlm.nih.gov/pubmed/20458016
//Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association.
//Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association.
#Jung-2015 pmid=25310992
#Jung-2015 https://www.ncbi.nlm.nih.gov/pubmed/25310992
//Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan.
//Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan.
#Lei-2015 http://journal.frontiersin.org/article/10.3389/fphys.2015.00294/full
#Lei-2015 http://journal.frontiersin.org/article/10.3389/fphys.2015.00294/full
//Fine particulate matter in acute exacerbation of COPD.
//Fine particulate matter in acute exacerbation of COPD.
#Hamra-2014 pmid=24911630
#Hamra-2014 https://www.ncbi.nlm.nih.gov/pubmed/24911630
//Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis.
//Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis.
#Liu-2015 pmid=25913161
#Liu-2015 https://www.ncbi.nlm.nih.gov/pubmed/25913161
//Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation.
//Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation.
#Riva-2011 pmid=21506876
#Riva-2011 https://www.ncbi.nlm.nih.gov/pubmed/21506876
//Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice.
//Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice.
#Levesque-2011 pmid=21561831
#Levesque-2011 https://www.ncbi.nlm.nih.gov/pubmed/21561831
//Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity.
//Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity.
#Morgan-2011 https://www.ncbi.nlm.nih.gov/pubmed/21724521
//Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro.
#Cheng-2010 http://www.tandfonline.com/doi/abs/10.1080/027868201753306714
//Chemical Composition of Aerosols from Kerosene Heaters Burning Jet Fuels.
#Ambroz-2016 https://www.ncbi.nlm.nih.gov/pubmed/27321041
//Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns.
#Balasubramanian-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402685/
//Differential effects of inhalation exposure to PM2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats.
#Lavicoli-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759935/
//The Effects of Nanomaterials as Endocrine Disruptors.
#Solt-2008 https://www.ncbi.nlm.nih.gov/pubmed/18349428
//Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults.
#Levesque-2013 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660420/
//The Role of MAC1 in Diesel Exhaust Particle-induced Microglial Activation and Loss of Dopaminergic Neuron Function
</biblio>
</biblio>


Revision as of 04:29, 19 January 2017

Work-in-progress. Please correct any errors found.

<sitesearch>title=Search this Project</sitesearch>

Customize your entry pages <html><img src="/images/a/aa/Help.png" border="0" /></html>


Recently Edited Notebook Pages

Hypothesis

1. Unilateral/clandestine geoengineering activity is a source of air pollution. (PM2.5)

2. The molecular toxicity of PM2.5 is poorly understood.

3. The nanotoxicity of PM2.5 on human health requires further investigations.

4. The differential effects of PM2.5 on the neuroimmune system, lung/brain axis, chronic inflammation, and neurodegenerative disorders (Alzheimer, Parkinson) requires additional research. [1]

5. MAC1 activation is implicated in the dopaminergic-mediated neurotoxicity of PM2.5. [2]

Differential effects of nanoparticles translocation

Cardiovascular system

  • Effects of particulate matter (PM2.5) air pollution on cardiovascular disease [3]
    • Increase in blood pressure (hypertension) [4]

Central nervous system

  • Alzheimer disease [5][2]
  • Parkinson disease [2]
  • PM2.5 exposure may cause chronic neuroinflammation and oxidative stress. [6][7][8][9]
  • PM2.5 exposure may induce selective neurotoxicity through glutamatergic signaling and increase NMDA-induced excitotoxicity. [7][10]
  • Cyclooxygenase-2, interleukin-1beta, and CD14 signaling upregulation. [11]
  • Microglia-mediated dopaminergic neurotoxicity (Reactive microgliosis). [2]

Endocrine system

  • Decrease of serum testosterone levels [12]
  • Increase of serum estradiol levels [12]
  • Chronic fatigue syndrome (CFS)

Lymphatic system

  • Lipid peroxidation and oxidative DNA/RNA damage. [13]

Respiratory system

  • AECOPD [6]
  • Lung cancer [14]

Nanotoxicity of aerosolized nanoparticles

Notes

Resources

Keywords

aerosol, bioaerosol, nanoparticles, aluminium oxide, particulate matter, PM2.5, gulf war syndrome, chronic neuroinflammation, vapor phase oxidation, hydrocarbons, barium, microglia, MAC1

Support this project

This project is entirely financed by personal donations. To support this project, use the following link to donate money via Paypal: https://paypal.me/EtienneRobillard

References

  1. https://www.ncbi.nlm.nih.gov/pubmed/15061611

    [Gilmour-2004]

    Differential pulmonary inflammation and in vitro cytotoxicity of size-fractionated fly ash particles from pulverized coal combustion.

  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660420/

    [Levesque-2013]

    The Role of MAC1 in Diesel Exhaust Particle-induced Microglial Activation and Loss of Dopaminergic Neuron Function

  3. https://www.ncbi.nlm.nih.gov/pubmed/20458016

    [Brook-2010]

    Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association.

  4. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402685/

    [Balasubramanian-2013]

    Differential effects of inhalation exposure to PM2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats.

  5. https://www.ncbi.nlm.nih.gov/pubmed/25310992

    [Jung-2015]

    Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan.

  6. http://journal.frontiersin.org/article/10.3389/fphys.2015.00294/full

    [Lei-2015]

    Fine particulate matter in acute exacerbation of COPD.

  7. https://www.ncbi.nlm.nih.gov/pubmed/25913161

    [Liu-2015]

    Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation.

  8. https://www.ncbi.nlm.nih.gov/pubmed/21506876

    [Riva-2011]

    Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice.

  9. https://www.ncbi.nlm.nih.gov/pubmed/21561831

    [Levesque-2011]

    Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity.

  10. https://www.ncbi.nlm.nih.gov/pubmed/21724521

    [Morgan-2011]

    Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro.

  11. https://www.ncbi.nlm.nih.gov/pubmed/18349428

    [Solt-2008]

    Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults.

  12. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759935/

    [Lavicoli-2013]

    The Effects of Nanomaterials as Endocrine Disruptors.

  13. https://www.ncbi.nlm.nih.gov/pubmed/27321041

    [Ambroz-2016]

    Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns.

  14. https://www.ncbi.nlm.nih.gov/pubmed/24911630

    [Hamra-2014]

    Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis.

  15. http://www.mdpi.com/1660-4601/12/8/9375/htm

    [Herndon-2015]

    Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health

  16. http://nuclearplanet.com/frontiers1.pdf

    [Herndon-2016]

    Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification.

  17. http://www.tandfonline.com/doi/abs/10.1080/027868201753306714

    [Cheng-2010]

    Chemical Composition of Aerosols from Kerosene Heaters Burning Jet Fuels.

License

Copyright (C) 2012-2016 Etienne Robillard

Permission is granted to copy, distribute and/or modify this document Under the terms of the GNU Free Documentation License, Version 1.3 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled "GNU Free Documentation License".



See you in space cowboy

"I am free, no matter what rules surround me. If I find them tolerable, I tolerate them; if I find them too obnoxious, I break them. I am free because I know that I alone am morally responsible for everything I do." -Robert A. Heinlein

"The essence of the independent mind lies not in what it thinks, but in how it thinks." ― Christopher Hitchens

"Now let us consider another kind of drug – still undiscovered, but probably just around the corner – a drug capable of making people feel happy in situations where they would normally feel miserable. Such a drug would be a blessing, but a blessing fraught with grave political dangers. By making harmless chemical euphoria freely available, a dictator could reconcile an entire population to a state of affairs to which self-respecting human beings ought not to be reconciled. Despots have always found it necessary to supplement force by political or religious propaganda. In this sense the pen is mightier than the sword. But mightier than either the pen or the sword is the pill. In mental hospitals it has been found that chemical restraint is far more effective than strait jackets or psychiatry. The dictatorships of tomorrow will deprive men of their freedom, but will give them in exchange a happiness none the less real, as a subjective experience, for being chemically induced. The pursuit of happiness is one of the traditional rights of man; unfortunately, the achievement of happiness may turn out to be incompatible with another of man's rights – liberty." - Aldous Huxley

Retrieved from "https://openwetware.org/mediawiki/index.php?title=User:Tkadm30/Notebook/chim_trills_notebook&oldid=969664"