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__TOC__
__TOC__


Hello and welcome to my chemtrails notebook. :)  
== Hypothesis ==
1. Unilateral/clandestine geoengineering activity is a source of air pollution/particulate matter. ('''PM2.5''')
 
2. The molecular toxicity of PM2.5 is poorly understood.


== Categories ==
3. The nanotoxicity of PM2.5 on human health requires further investigations.


=== Challenges and goals ===
4. The differential effects of PM2.5 on the neuroimmune system, lung/brain axis, chronic inflammation, and neurodegenerative disorders (Alzheimer, Parkinson) requires additional research. <cite>Gilmour-2004</cite>


* Identify the bioaerosol(s) chemical origins and their chronic exposure effects on human health.
5. MAC1 activation is implicated in the dopaminergic-mediated neurotoxicity of PM2.5. <cite>Levesque-2013</cite>
* Elucidate the synthetic origins of the pathogen metabolism.
* [XXX Other challenges/goals here..]


=== Bioaerosol/biopesticide exposure evidences ===
== Differential effects of nanoparticles translocation ==
=== Cardiovascular system ===
* Effects of particulate matter (PM2.5) air pollution on cardiovascular disease <cite>Brook-2010</cite>
** Increase in blood pressure (hypertension) <cite>Balasubramanian-2013</cite>


* [http://openwetware.org/wiki/Image:3133.jpeg Unidentified and suspicious experiment(s), sample picture 1, Montreal, Quebec, 2010]
=== Central nervous system ===
** Upon injection in the atmosphere, a chemical reaction seem to occur and can last for days until the particles in suspension dissipates. This phenomenon therefore may produces the albedo modifications using DMSO based solutions, which further restrict the daytime period and create the so-called "greenhouse" effect, resulting in extreme temperature variations and weird man-made climatic modifications..
* Alzheimer disease <cite>Jung-2015</cite><cite>Levesque-2013</cite>
* [http://openwetware.org/wiki/Image:P8270174.JPG Unidentified and suspicious experiment(s), sample picture 2, Laval, Quebec, 2010]
* Parkinson disease <cite>Levesque-2013</cite>
* PM2.5 exposure may cause chronic neuroinflammation and oxidative stress. <cite>Lei-2015</cite><cite>Liu-2015</cite><cite>Riva-2011</cite><cite>Levesque-2011</cite>
* PM2.5 exposure may induce selective neurotoxicity through glutamatergic signaling and increase NMDA-induced excitotoxicity. <cite>Liu-2015</cite><cite>Morgan-2011</cite>
* Cyclooxygenase-2, interleukin-1beta, and CD14 signaling upregulation. <cite>Solt-2008</cite>
* Microglia-mediated dopaminergic neurotoxicity (Reactive microgliosis). <cite>Levesque-2013</cite>


=== Molecular fingerprints of the pathogen ===
=== Endocrine system ===
* Decrease of serum testosterone levels <cite>Lavicoli-2013</cite>
* Increase of serum estradiol levels <cite>Lavicoli-2013</cite>
* Chronic fatigue syndrome (CFS)


==== Getting started... ====
=== Lymphatic system ===
* Lipid peroxidation and oxidative DNA/RNA damage. <cite>Ambroz-2016</cite>


* [http://openwetware.org/wiki/User:Etienne_Robillard/Notebook/Chemtrails911_notebook/DMSO DMSO]: A short primer on DMSO molecular properties. (a polar aprotic solvent)
=== Respiratory system ===
* AECOPD <cite>Lei-2015</cite>
* Lung cancer <cite>Hamra-2014</cite>


==== Molecular and genetic evidences of active neurocognitive impairment involving suspicious bioaerosol(s) exposures ====  
== Nanotoxicity of aerosolized nanoparticles ==
* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/2014/12/14|Notebook]]


Things you should consider in this area:
== Notes ==
* Aerosolized nanoparticles:
** [http://www.energy.psu.edu/sites/default/files/files/JetFuels.pdf Advanced Thermally Stable Jet Fuels]
** [http://www.energy.psu.edu/sites/default/files/files/coalbased_jetfuel.pdf The Coal-Based Jet Fuel Program]
** [http://web.stanford.edu/group/pitsch/publication/ColketJet_Fuel_Surrogate_AIAA_2007.pdf Jet Fuel Surrogate Research]
** [https://dspace.mit.edu/handle/1721.1/9116 Catalytic combustion of methane with nanostructured barium hexaaluminate-based materials]
* Discussion:
** [http://www.thenakedscientists.com/forum/index.php?topic=68004 Do coal-based jet fuel (JP-900) emit ultrafine particles?]
** [http://www.thenakedscientists.com/forum/index.php?topic=67942 Is coal fly ash a synthetic compound?]
** [http://www.thenakedscientists.com/forum/index.php?topic=68555 Is reactive microgliosis a beneficial or harmful process?]
** [http://www.thenakedscientists.com/forum/index.php?topic=67302 Should we ban geoengineering?]
** [http://www.thenakedscientists.com/forum/index.php?topic=68061 What is the Gulf War syndrome?]
** [http://www.thenakedscientists.com/forum/index.php?topic=68101 What is a jet fuel surrogate?]
* Documentation:
** [https://en.wikipedia.org/wiki/Dodecane Dodecane (Wikipedia)]
** [https://en.wikipedia.org/wiki/Ethylbenzene Ethylbenzene (Wikipedia)]
** [http://www.ncbi.nlm.nih.gov/gene/2744 Glutaminase]
** [http://www.ncbi.nlm.nih.gov/pubmed/?term=gulf+war+syndrome Gulf War syndrome (PubMed search)]
** [https://en.wikipedia.org/wiki/Gulf_War_syndrome Gulf War syndrome (Wikipedia)]
** [https://en.wikipedia.org/wiki/Methylcyclohexane Methylcyclohexane (Wikipedia)]


* [[Schizophrenia]] and schizophrenia-like mental disorders.
== Resources ==
* Glutamate excitotoxicity, monoamines, and atypical chemotherapy.
* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/Introduction|Introduction]]
* Chiral drug biosynthesis using a "enantioselective" chemical reaction.
* [[User:Etienne_Robillard/Notebook/Brainstorming|Brainstorming]]
* Elucidate the meaning of "[http://en.wikipedia.org/wiki/Subliminal_stimuli#cite_note-schizo-36 impaired conscious access]"; Ie: Drugs designed to enhance brain subliminal processing functions? (research)
* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/Model|Model]]
* Measuring the magnitude (intensity), duration, scale, and frequency of the experiment(s) on (heterogeneous) civilian populations.
* [[User:Etienne_Robillard/Notebook/Photographic_evidences|Photographic evidences]]
* Psychological specificity of neurocognitive impairments vary on per-organism basis and is largely mediated from "genetic" (proteins) expressions.
* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/Research|Research]]
* Cell-phones and electromagnetical pollution?
* Ordinary people (ie: non-programmers), may have difficulties finding the "Talk/Reply" button..


==== Progressive immunization/chemotherapy evidences ====
== Keywords ==
aerosol, bioaerosol, nanoparticles, aluminium oxide, particulate matter, PM2.5, gulf war syndrome, chronic neuroinflammation, vapor phase oxidation, hydrocarbons, barium, microglia, MAC1


What are the long-term effects of mass gene therapy on heterogenous populations?
== Support this project ==


In this section, the proposed learning objective are to uncover and define the primary
This project is entirely financed by personal donations. To support this project, use the following link
pathogenic functions of the suspicious bioaerosols exposure(s), perniciously implemented
to donate money via Paypal: https://paypal.me/EtienneRobillard
on non-consenting and disinformed populations.  


* [http://openwetware.org/index.php?title=User:Etienne_Robillard/Notebook/Chemtrails911_notebook/Biopesticides Biopesticides]: Unit 1: Introduction to biopesticides and organic sulfoxides chemistry. (Work-in-progress..)
== References ==
<biblio>
#Herndon-2015 http://www.mdpi.com/1660-4601/12/8/9375/htm
//Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health
#Herndon-2016 http://nuclearplanet.com/frontiers1.pdf
//Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification.
#Gilmour-2004 https://www.ncbi.nlm.nih.gov/pubmed/15061611
//Differential pulmonary inflammation and in vitro cytotoxicity of size-fractionated fly ash particles from pulverized coal combustion.
#Brook-2010 https://www.ncbi.nlm.nih.gov/pubmed/20458016
//Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association.
#Jung-2015 https://www.ncbi.nlm.nih.gov/pubmed/25310992
//Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan.
#Lei-2015 http://journal.frontiersin.org/article/10.3389/fphys.2015.00294/full
//Fine particulate matter in acute exacerbation of COPD.
#Hamra-2014 https://www.ncbi.nlm.nih.gov/pubmed/24911630
//Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis.
#Liu-2015 https://www.ncbi.nlm.nih.gov/pubmed/25913161
//Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation.
#Riva-2011 https://www.ncbi.nlm.nih.gov/pubmed/21506876
//Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice.
#Levesque-2011 https://www.ncbi.nlm.nih.gov/pubmed/21561831
//Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity.
#Morgan-2011 https://www.ncbi.nlm.nih.gov/pubmed/21724521
//Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro.
#Cheng-2010 http://www.tandfonline.com/doi/abs/10.1080/027868201753306714
//Chemical Composition of Aerosols from Kerosene Heaters Burning Jet Fuels.
#Ambroz-2016 https://www.ncbi.nlm.nih.gov/pubmed/27321041
//Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns.
#Balasubramanian-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402685/
//Differential effects of inhalation exposure to PM2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats.
#Lavicoli-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759935/
//The Effects of Nanomaterials as Endocrine Disruptors.
#Solt-2008 https://www.ncbi.nlm.nih.gov/pubmed/18349428
//Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults.
#Levesque-2013 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660420/
//The Role of MAC1 in Diesel Exhaust Particle-induced Microglial Activation and Loss of Dopaminergic Neuron Function
</biblio>


At the end of this learning objective, you should have gathered basic knowledge on:
== License ==


* Foreign gene acquisition and genetically acquired immunogenic resistance (B cells lymphocytes)
Copyright (C) 2012-2016 Etienne Robillard
* Quorum sensing


[[Category: CanadaInDistressCategory]]
Permission is granted to copy, distribute and/or modify this document
Under the terms of the GNU Free Documentation License, Version 1.3
or any later version published by the Free Software Foundation;
with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts.
A copy of the license is included in the section entitled "GNU Free Documentation License".


== Quotes ==


* "During times of universal deceit, telling the truth becomes a revolutionary act." -- George Orwell (1984)
__NOTOC__
* "We shall defend our island, whatever the cost may be, we shall fight on the beaches, we shall fight on the landing grounds, we shall fight in the fields and in the streets, we shall fight in the hills; we shall never surrender." -- Winston Churchill


== See also ==
== See you in space cowboy ==
* [http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/otherendo/pineal.html Pineal Gland and Melatonin]
* [http://www.biology.arizona.edu/biochemistry/problem_sets/aa/aa.html The Chemistry of Amino Acids]
* [http://www.chem.ucalgary.ca/courses/351/Carey5th/Ch08/ch8-8.html Solvents Effects]
* [http://toxsci.oxfordjournals.org/content/76/1/131/F1.large.jpg Fatty Acid Amide Hydrolase]
* [http://faculty.ccbcmd.edu/courses/bio141/lecguide/unit4/antigens/antigens.html The Adaptive Immune System: Antigens]
* [http://pf11.blogspot.com/2010/03/zoonotic-h9n2-avian-influenza-further.html "The truth is in the sequences."]
* [http://en.wikiversity.org/wiki/Introduction_to_psychology/Consciousness Introduction to psychology: Consciousness]
* [http://www.naturalnews.com/034906_Bill_Gates_geo-engineering_chemtrails.html Bill Gates exposed for funding research, promotion of spraying geo-engineered 'chemtrails' across globe] (2012/02/08)
----


{{LnNotebookRecentChanges2}}
<blockquote>
"I am free, no matter what rules surround me. If I find them tolerable, I tolerate them; if I find them too obnoxious, I break them.
I am free because I know that I alone am morally responsible for everything I do." -Robert A. Heinlein
</blockquote>


<blockquote>
"The essence of the independent mind lies not in what it thinks, but in how it thinks."
― Christopher Hitchens
</blockquote>


__NOTOC__
<blockquote>"Now let us consider another kind of drug – still undiscovered, but probably just around the corner – a drug capable of making people feel happy in situations where they would normally feel miserable. Such a drug would be a blessing, but a blessing fraught with grave political dangers. By making harmless chemical euphoria freely available, a dictator could reconcile an entire population to a state of affairs to which self-respecting human beings ought not to be reconciled. Despots have always found it necessary to supplement force by political or religious propaganda. In this sense the pen is mightier than the sword. But mightier than either the pen or the sword is the pill. In mental hospitals it has been found that chemical restraint is far more effective than strait jackets or psychiatry. The dictatorships of tomorrow will deprive men of their freedom, but will give them in exchange a happiness none the less real, as a subjective experience, for being chemically induced. The pursuit of happiness is one of the traditional rights of man; unfortunately, the achievement of happiness may turn out to be incompatible with another of man's rights – liberty." - Aldous Huxley
</blockquote>

Revision as of 04:00, 14 February 2017

Work-in-progress. Please correct any errors found.

<sitesearch>title=Search this Project</sitesearch>

Customize your entry pages <html><img src="/images/a/aa/Help.png" border="0" /></html>


Recently Edited Notebook Pages

Hypothesis

1. Unilateral/clandestine geoengineering activity is a source of air pollution/particulate matter. (PM2.5)

2. The molecular toxicity of PM2.5 is poorly understood.

3. The nanotoxicity of PM2.5 on human health requires further investigations.

4. The differential effects of PM2.5 on the neuroimmune system, lung/brain axis, chronic inflammation, and neurodegenerative disorders (Alzheimer, Parkinson) requires additional research. [1]

5. MAC1 activation is implicated in the dopaminergic-mediated neurotoxicity of PM2.5. [2]

Differential effects of nanoparticles translocation

Cardiovascular system

  • Effects of particulate matter (PM2.5) air pollution on cardiovascular disease [3]
    • Increase in blood pressure (hypertension) [4]

Central nervous system

  • Alzheimer disease [5][2]
  • Parkinson disease [2]
  • PM2.5 exposure may cause chronic neuroinflammation and oxidative stress. [6][7][8][9]
  • PM2.5 exposure may induce selective neurotoxicity through glutamatergic signaling and increase NMDA-induced excitotoxicity. [7][10]
  • Cyclooxygenase-2, interleukin-1beta, and CD14 signaling upregulation. [11]
  • Microglia-mediated dopaminergic neurotoxicity (Reactive microgliosis). [2]

Endocrine system

  • Decrease of serum testosterone levels [12]
  • Increase of serum estradiol levels [12]
  • Chronic fatigue syndrome (CFS)

Lymphatic system

  • Lipid peroxidation and oxidative DNA/RNA damage. [13]

Respiratory system

  • AECOPD [6]
  • Lung cancer [14]

Nanotoxicity of aerosolized nanoparticles

Notes

Resources

Keywords

aerosol, bioaerosol, nanoparticles, aluminium oxide, particulate matter, PM2.5, gulf war syndrome, chronic neuroinflammation, vapor phase oxidation, hydrocarbons, barium, microglia, MAC1

Support this project

This project is entirely financed by personal donations. To support this project, use the following link to donate money via Paypal: https://paypal.me/EtienneRobillard

References

  1. https://www.ncbi.nlm.nih.gov/pubmed/15061611

    [Gilmour-2004]

    Differential pulmonary inflammation and in vitro cytotoxicity of size-fractionated fly ash particles from pulverized coal combustion.

  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660420/

    [Levesque-2013]

    The Role of MAC1 in Diesel Exhaust Particle-induced Microglial Activation and Loss of Dopaminergic Neuron Function

  3. https://www.ncbi.nlm.nih.gov/pubmed/20458016

    [Brook-2010]

    Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association.

  4. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402685/

    [Balasubramanian-2013]

    Differential effects of inhalation exposure to PM2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats.

  5. https://www.ncbi.nlm.nih.gov/pubmed/25310992

    [Jung-2015]

    Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan.

  6. http://journal.frontiersin.org/article/10.3389/fphys.2015.00294/full

    [Lei-2015]

    Fine particulate matter in acute exacerbation of COPD.

  7. https://www.ncbi.nlm.nih.gov/pubmed/25913161

    [Liu-2015]

    Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation.

  8. https://www.ncbi.nlm.nih.gov/pubmed/21506876

    [Riva-2011]

    Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice.

  9. https://www.ncbi.nlm.nih.gov/pubmed/21561831

    [Levesque-2011]

    Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity.

  10. https://www.ncbi.nlm.nih.gov/pubmed/21724521

    [Morgan-2011]

    Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro.

  11. https://www.ncbi.nlm.nih.gov/pubmed/18349428

    [Solt-2008]

    Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults.

  12. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759935/

    [Lavicoli-2013]

    The Effects of Nanomaterials as Endocrine Disruptors.

  13. https://www.ncbi.nlm.nih.gov/pubmed/27321041

    [Ambroz-2016]

    Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns.

  14. https://www.ncbi.nlm.nih.gov/pubmed/24911630

    [Hamra-2014]

    Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis.

  15. http://www.mdpi.com/1660-4601/12/8/9375/htm

    [Herndon-2015]

    Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health

  16. http://nuclearplanet.com/frontiers1.pdf

    [Herndon-2016]

    Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification.

  17. http://www.tandfonline.com/doi/abs/10.1080/027868201753306714

    [Cheng-2010]

    Chemical Composition of Aerosols from Kerosene Heaters Burning Jet Fuels.

License

Copyright (C) 2012-2016 Etienne Robillard

Permission is granted to copy, distribute and/or modify this document Under the terms of the GNU Free Documentation License, Version 1.3 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled "GNU Free Documentation License".



See you in space cowboy

"I am free, no matter what rules surround me. If I find them tolerable, I tolerate them; if I find them too obnoxious, I break them. I am free because I know that I alone am morally responsible for everything I do." -Robert A. Heinlein

"The essence of the independent mind lies not in what it thinks, but in how it thinks." ― Christopher Hitchens

"Now let us consider another kind of drug – still undiscovered, but probably just around the corner – a drug capable of making people feel happy in situations where they would normally feel miserable. Such a drug would be a blessing, but a blessing fraught with grave political dangers. By making harmless chemical euphoria freely available, a dictator could reconcile an entire population to a state of affairs to which self-respecting human beings ought not to be reconciled. Despots have always found it necessary to supplement force by political or religious propaganda. In this sense the pen is mightier than the sword. But mightier than either the pen or the sword is the pill. In mental hospitals it has been found that chemical restraint is far more effective than strait jackets or psychiatry. The dictatorships of tomorrow will deprive men of their freedom, but will give them in exchange a happiness none the less real, as a subjective experience, for being chemically induced. The pursuit of happiness is one of the traditional rights of man; unfortunately, the achievement of happiness may turn out to be incompatible with another of man's rights – liberty." - Aldous Huxley

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