User:Tkadm30/Notebook/chim trills notebook: Difference between revisions
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'''Work-in-progress | '''Work-in-progress.''' | ||
{|{{table}} width="800" | {|{{table}} width="800" | ||
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== Hypothesis == | == Hypothesis == | ||
1. | 1. Unilateral/clandestine geoengineering activity is a source of air pollution/particulate matter. ('''PM2.5''') | ||
2. The | 2. The molecular toxicity of PM2.5 is poorly understood. | ||
3. The | 3. The nanotoxicity, neurotoxicity, and genotoxicity of PM2.5 exposure on human health requires further investigations. | ||
4. | 4. The differential effects of chronic PM2.5 exposure on the neuroimmune system, lung/brain axis, chronic inflammation, and neurodegenerative disorders (Alzheimer, Parkinson) requires additional research. <cite>Gilmour-2004</cite> | ||
== Differential effects of | 5. MAC1/Glutaminase activation is implicated in the microglia-mediated dopaminergic neurotoxicity of PM2.5. <cite>Levesque-2013</cite><cite>Liu-2015</cite> | ||
== Differential effects of nanoparticles translocation == | |||
=== Cardiovascular system === | === Cardiovascular system === | ||
* Effects of particulate matter (PM2.5) air pollution on cardiovascular | * Effects of particulate matter (PM2.5) air pollution on cardiovascular diseases. <cite>Brook-2010</cite> | ||
** Increase in blood pressure <cite>Balasubramanian-2013</cite> | ** Increase in blood pressure (hypertension) <cite>Balasubramanian-2013</cite> | ||
** The association of annual air pollution exposure with blood pressure among patients with sleep-disordered breathing. <cite>Liu-2016</cite> | |||
* Dysregulation of miRNA expression levels. <cite>Lu-2015</cite> | |||
=== Central nervous system === | === Central nervous system === | ||
* Alzheimer disease <cite>Jung-2015</cite><cite>Levesque-2013</cite> | * Alzheimer disease <cite>Jung-2015</cite><cite>Levesque-2013</cite> | ||
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* Decrease of serum testosterone levels <cite>Lavicoli-2013</cite> | * Decrease of serum testosterone levels <cite>Lavicoli-2013</cite> | ||
* Increase of serum estradiol levels <cite>Lavicoli-2013</cite> | * Increase of serum estradiol levels <cite>Lavicoli-2013</cite> | ||
* Autoimmune disorders <cite>Bernatsky-2016</cite> | |||
=== Limbic system === | |||
* Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus. <cite>Chao-2017</cite> | |||
=== Lymphatic system === | === Lymphatic system === | ||
* Lipid peroxidation and oxidative DNA damage. <cite>Ambroz-2016</cite> | * Lipid peroxidation and oxidative DNA/RNA damage. <cite>Ambroz-2016</cite> | ||
=== Respiratory system === | === Respiratory system === | ||
* AECOPD <cite>Lei-2015</cite> | * AECOPD <cite>Lei-2015</cite> | ||
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== Notes == | == Notes == | ||
* | * Condensation aerosols: | ||
** [http://iopscience.iop.org/article/10.1070/RC1965v034n02ABEH001418/pdf Monodisperse aerosols] | |||
* Coal-Based Jet Fuels: | |||
** [http://www.energy.psu.edu/sites/default/files/files/JetFuels.pdf Advanced Thermally Stable Jet Fuels] | ** [http://www.energy.psu.edu/sites/default/files/files/JetFuels.pdf Advanced Thermally Stable Jet Fuels] | ||
** [http://www.energy.psu.edu/sites/default/files/files/coalbased_jetfuel.pdf The Coal-Based Jet Fuel Program] | ** [http://www.energy.psu.edu/sites/default/files/files/coalbased_jetfuel.pdf The Coal-Based Jet Fuel Program] | ||
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== Keywords == | == Keywords == | ||
aerosol, bioaerosol, nanoparticles, aluminium oxide, particulate matter, PM2.5, gulf war syndrome, chronic neuroinflammation, vapor phase oxidation, hydrocarbons, barium, microglia, MAC1, monodisperse aerosol, drug delivery | |||
aerosol, bioaerosol, nanoparticles, aluminium oxide, particulate matter, PM2.5 | |||
== Support this project == | == Support this project == | ||
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#Herndon-2016 http://nuclearplanet.com/frontiers1.pdf | #Herndon-2016 http://nuclearplanet.com/frontiers1.pdf | ||
//Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification. | //Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification. | ||
#Gilmour-2004 | #Gilmour-2004 https://www.ncbi.nlm.nih.gov/pubmed/15061611 | ||
//Differential pulmonary inflammation and in vitro cytotoxicity of size-fractionated fly ash particles from pulverized coal combustion. | //Differential pulmonary inflammation and in vitro cytotoxicity of size-fractionated fly ash particles from pulverized coal combustion. | ||
#Brook-2010 | #Brook-2010 https://www.ncbi.nlm.nih.gov/pubmed/20458016 | ||
//Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. | //Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. | ||
#Jung-2015 | #Jung-2015 https://www.ncbi.nlm.nih.gov/pubmed/25310992 | ||
//Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan. | //Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan. | ||
#Lei-2015 http://journal.frontiersin.org/article/10.3389/fphys.2015.00294/full | #Lei-2015 http://journal.frontiersin.org/article/10.3389/fphys.2015.00294/full | ||
//Fine particulate matter in acute exacerbation of COPD. | //Fine particulate matter in acute exacerbation of COPD. | ||
#Hamra-2014 | #Hamra-2014 https://www.ncbi.nlm.nih.gov/pubmed/24911630 | ||
//Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis. | //Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis. | ||
#Liu-2015 | #Liu-2015 https://www.ncbi.nlm.nih.gov/pubmed/25913161 | ||
//Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation. | //Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation. | ||
#Riva-2011 | #Riva-2011 https://www.ncbi.nlm.nih.gov/pubmed/21506876 | ||
//Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice. | //Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice. | ||
#Levesque-2011 | #Levesque-2011 https://www.ncbi.nlm.nih.gov/pubmed/21561831 | ||
//Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity. | //Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity. | ||
#Morgan-2011 | #Morgan-2011 https://www.ncbi.nlm.nih.gov/pubmed/21724521 | ||
//Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro. | //Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro. | ||
#Cheng-2010 http://www.tandfonline.com/doi/abs/10.1080/027868201753306714 | #Cheng-2010 http://www.tandfonline.com/doi/abs/10.1080/027868201753306714 | ||
//Chemical Composition of Aerosols from Kerosene Heaters Burning Jet Fuels. | //Chemical Composition of Aerosols from Kerosene Heaters Burning Jet Fuels. | ||
#Ambroz-2016 | #Ambroz-2016 https://www.ncbi.nlm.nih.gov/pubmed/27321041 | ||
//Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns. | //Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns. | ||
#Balasubramanian-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402685/ | #Balasubramanian-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402685/ | ||
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#Lavicoli-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759935/ | #Lavicoli-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759935/ | ||
//The Effects of Nanomaterials as Endocrine Disruptors. | //The Effects of Nanomaterials as Endocrine Disruptors. | ||
#Solt-2008 | #Solt-2008 https://www.ncbi.nlm.nih.gov/pubmed/18349428 | ||
//Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults. | //Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults. | ||
#Levesque-2013 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660420/ | #Levesque-2013 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660420/ | ||
//The Role of MAC1 in Diesel Exhaust Particle-induced Microglial Activation and Loss of Dopaminergic Neuron Function | //The Role of MAC1 in Diesel Exhaust Particle-induced Microglial Activation and Loss of Dopaminergic Neuron Function | ||
#Chao-2017 https://www.ncbi.nlm.nih.gov/pubmed/27539004 | |||
//Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus. | |||
#Liu-2016 https://www.ncbi.nlm.nih.gov/pubmed/26580727 | |||
//The association of annual air pollution exposure with blood pressure among patients with sleep-disordered breathing. | |||
#Bernatsky-2016 https://www.ncbi.nlm.nih.gov/pubmed/25988990 | |||
//Fine particulate air pollution, nitrogen dioxide, and systemic autoimmune rheumatic disease in Calgary, Alberta. | |||
#Lu-2015 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782360/ | |||
//Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals | |||
</biblio> | </biblio> | ||
== License == | == License == | ||
Copyright (C) 2012- | Copyright (C) 2012-2017 Etienne Robillard | ||
Permission is granted to copy, distribute and/or modify this document | Permission is granted to copy, distribute and/or modify this document |
Revision as of 11:10, 18 March 2017
Work-in-progress.
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Hypothesis1. Unilateral/clandestine geoengineering activity is a source of air pollution/particulate matter. (PM2.5) 2. The molecular toxicity of PM2.5 is poorly understood. 3. The nanotoxicity, neurotoxicity, and genotoxicity of PM2.5 exposure on human health requires further investigations. 4. The differential effects of chronic PM2.5 exposure on the neuroimmune system, lung/brain axis, chronic inflammation, and neurodegenerative disorders (Alzheimer, Parkinson) requires additional research. [1] 5. MAC1/Glutaminase activation is implicated in the microglia-mediated dopaminergic neurotoxicity of PM2.5. [2][3] Differential effects of nanoparticles translocationCardiovascular system
Central nervous system
Endocrine system
Limbic system
Lymphatic system
Respiratory systemNanotoxicity of aerosolized nanoparticlesNotes
ResourcesKeywordsaerosol, bioaerosol, nanoparticles, aluminium oxide, particulate matter, PM2.5, gulf war syndrome, chronic neuroinflammation, vapor phase oxidation, hydrocarbons, barium, microglia, MAC1, monodisperse aerosol, drug delivery Support this projectThis project is entirely financed by personal donations. To support this project, use the following link to donate money via Paypal: https://paypal.me/EtienneRobillard References
LicenseCopyright (C) 2012-2017 Etienne Robillard Permission is granted to copy, distribute and/or modify this document Under the terms of the GNU Free Documentation License, Version 1.3 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled "GNU Free Documentation License".
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