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__TOC__
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Hello and welcome to my chemtrails notebook. :)  
== Hypothesis ==
1. Unilateral/clandestine geoengineering activity is a source of air pollution/particulate matter. ('''PM2.5''')


== Categories ==
2. The molecular toxicity of PM2.5 is poorly understood.


=== Challenges and goals ===
3. The nanotoxicity, neurotoxicity, and genotoxicity of PM2.5 exposure on human health requires further investigations.


* Identify the bioaerosol(s) chemical origins and their chronic exposure effects on human health.
4. The differential effects of chronic PM2.5 exposure on the neuroimmune system, lung/brain axis, chronic inflammation, and neurodegenerative disorders (Alzheimer, Parkinson) requires additional research. <cite>Gilmour-2004</cite>
* Elucidate the synthetic origins of the pathogen metabolism.
* [XXX Other challenges/goals here..]


=== Bioaerosol/biopesticide exposure evidences ===
5. MAC1/Glutaminase activation is implicated in the microglia-mediated dopaminergic neurotoxicity of PM2.5. <cite>Levesque-2013</cite><cite>Liu-2015</cite>


* [http://openwetware.org/wiki/Image:3133.jpeg Unidentified and suspicious experiment(s), sample picture 1, Montreal, Quebec, 2010]
== Differential effects of nanoparticles translocation ==
** Upon injection in the atmosphere, a chemical reaction seem to occur and can last for days until the particles in suspension dissipates. This phenomenon therefore may produces the albedo modifications using DMSO based solutions, which further restrict the daytime period and create the so-called "greenhouse" effect, resulting in extreme temperature variations and weird man-made climatic modifications..
=== Cardiovascular system ===
* [http://openwetware.org/wiki/Image:P8270174.JPG Unidentified and suspicious experiment(s), sample picture 2, Laval, Quebec, 2010]
* Effects of particulate matter (PM2.5) air pollution on cardiovascular diseases. <cite>Brook-2010</cite>
** Increase in blood pressure (hypertension) <cite>Balasubramanian-2013</cite>
** The association of annual air pollution exposure with blood pressure among patients with sleep-disordered breathing. <cite>Liu-2016</cite>
* Dysregulation of miRNA expression levels. <cite>Lu-2015</cite>


=== Molecular fingerprints of the pathogen ===
=== Central nervous system ===
* Alzheimer disease <cite>Jung-2015</cite><cite>Levesque-2013</cite>
* Parkinson disease <cite>Levesque-2013</cite>
* PM2.5 exposure may cause chronic neuroinflammation and oxidative stress. <cite>Lei-2015</cite><cite>Liu-2015</cite><cite>Riva-2011</cite><cite>Levesque-2011</cite>
* PM2.5 exposure may induce selective neurotoxicity through glutamatergic signaling and increase NMDA-induced excitotoxicity. <cite>Liu-2015</cite><cite>Morgan-2011</cite>
* Cyclooxygenase-2, interleukin-1beta, and CD14 signaling upregulation. <cite>Solt-2008</cite>
* Microglia-mediated dopaminergic neurotoxicity (Reactive microgliosis). <cite>Levesque-2013</cite>


==== Getting started... ====
=== Endocrine system ===
* Decrease of serum testosterone levels <cite>Lavicoli-2013</cite>
* Increase of serum estradiol levels <cite>Lavicoli-2013</cite>
* Autoimmune disorders <cite>Bernatsky-2016</cite>


* [http://openwetware.org/wiki/User:Etienne_Robillard/Notebook/Chemtrails911_notebook/DMSO DMSO]: A short primer on DMSO molecular properties. (a polar aprotic solvent)
=== Limbic system ===
* Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus. <cite>Chao-2017</cite>


==== Pathogenic evidences of active neurocognitive impairment involving suspicious bioaerosol(s) exposures ====  
=== Lymphatic system ===
* Lipid peroxidation and oxidative DNA/RNA damage. <cite>Ambroz-2016</cite>


Things you should consider in this area:
=== Respiratory system ===
* AECOPD <cite>Lei-2015</cite>
* Chiral (pro)drug biosynthesis using DNA/RNA polymerase (regulation) genes?
* Lung cancer <cite>Hamra-2014</cite>
** Keywords: Organo Catalysis, Catalase, N-acetyltransferase (GCN-5),NAT2, AANAT, Serotonin, ''S. marcescens'', DMSO
** Enzymatic-based catalysis of proteiogenic amino acids? (Gly,T,Cys,His,Glu,Ser)
* [http://en.wikibooks.org/wiki/Structural_Biochemistry/Enzyme/Catalytic_Triad Catalytic Triads]
* Elucidate the meaning of "[http://en.wikipedia.org/wiki/Subliminal_stimuli#cite_note-schizo-36 impaired conscious access]"; Ie: Drugs designed to enhance brain subliminal processing functions? (research)
* Measuring the magnitude (intensity), duration, scale, and frequency of the experiment(s) on (heterogeneous) civilian populations.
* Cell-phones and electromagnetical pollution?
* Ordinary people (ie: non-programmers), may have difficulties finding the "Talk/Reply" button..


==== Progressive immunization/chemotherapy evidences ====
== Nanotoxicity of aerosolized nanoparticles ==
* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/2014/12/14|Notebook]]


What are the long-term effects of mass gene therapy on heterogenous populations?
== Notes ==
* Condensation aerosols:
** [http://iopscience.iop.org/article/10.1070/RC1965v034n02ABEH001418/pdf Monodisperse aerosols]
* Coal-Based Jet Fuels:
** [http://www.energy.psu.edu/sites/default/files/files/JetFuels.pdf Advanced Thermally Stable Jet Fuels]
** [http://www.energy.psu.edu/sites/default/files/files/coalbased_jetfuel.pdf The Coal-Based Jet Fuel Program]
** [http://web.stanford.edu/group/pitsch/publication/ColketJet_Fuel_Surrogate_AIAA_2007.pdf Jet Fuel Surrogate Research]
** [https://dspace.mit.edu/handle/1721.1/9116 Catalytic combustion of methane with nanostructured barium hexaaluminate-based materials]
* Discussion:
** [http://www.thenakedscientists.com/forum/index.php?topic=68004 Do coal-based jet fuel (JP-900) emit ultrafine particles?]
** [http://www.thenakedscientists.com/forum/index.php?topic=67942 Is coal fly ash a synthetic compound?]
** [http://www.thenakedscientists.com/forum/index.php?topic=68555 Is reactive microgliosis a beneficial or harmful process?]
** [http://www.thenakedscientists.com/forum/index.php?topic=67302 Should we ban geoengineering?]
** [http://www.thenakedscientists.com/forum/index.php?topic=68061 What is the Gulf War syndrome?]
** [http://www.thenakedscientists.com/forum/index.php?topic=68101 What is a jet fuel surrogate?]
* Documentation:
** [https://en.wikipedia.org/wiki/Dodecane Dodecane (Wikipedia)]
** [https://en.wikipedia.org/wiki/Ethylbenzene Ethylbenzene (Wikipedia)]
** [http://www.ncbi.nlm.nih.gov/gene/2744 Glutaminase]
** [http://www.ncbi.nlm.nih.gov/pubmed/?term=gulf+war+syndrome Gulf War syndrome (PubMed search)]
** [https://en.wikipedia.org/wiki/Gulf_War_syndrome Gulf War syndrome (Wikipedia)]
** [https://en.wikipedia.org/wiki/Methylcyclohexane Methylcyclohexane (Wikipedia)]


In this section, the proposed learning objective are to uncover and define the primary
== Resources ==
pathogenic functions of the suspicious bioaerosols exposure(s), perniciously implemented
* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/Introduction|Introduction]]
on non-consenting and disinformed populations.
* [[User:Etienne_Robillard/Notebook/Brainstorming|Brainstorming]]
* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/Model|Model]]
* [[User:Etienne_Robillard/Notebook/Photographic_evidences|Photographic evidences]]
* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/Research|Research]]


* [http://openwetware.org/index.php?title=User:Etienne_Robillard/Notebook/Chemtrails911_notebook/Biopesticides Biopesticides]: Unit 1: Introduction to biopesticides and organic sulfoxides chemistry. (Work-in-progress..)
== Keywords ==
aerosol, bioaerosol, nanoparticles, aluminium oxide, particulate matter, PM2.5, gulf war syndrome, chronic neuroinflammation, vapor phase oxidation, hydrocarbons, barium, microglia, MAC1, monodisperse aerosol, drug delivery


At the end of this learning objective, you should have gathered basic knowledge on:
== Support this project ==


* Foreign gene acquisition and genetically acquired immunogenic resistance (B cells lymphocytes)
This project is entirely financed by personal donations. To support this project, use the following link
* Quorum Sensing and Synthetic Quorum Sensing
to donate money via Paypal: https://paypal.me/EtienneRobillard
** [http://www.che.psu.edu/faculty/wood/group/pub.htm Recent studies]


[[Category: CanadaInDistressCategory]]
== References ==
<biblio>
#Herndon-2015 http://www.mdpi.com/1660-4601/12/8/9375/htm
//Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health
#Herndon-2016 http://nuclearplanet.com/frontiers1.pdf
//Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification.
#Gilmour-2004 https://www.ncbi.nlm.nih.gov/pubmed/15061611
//Differential pulmonary inflammation and in vitro cytotoxicity of size-fractionated fly ash particles from pulverized coal combustion.
#Brook-2010 https://www.ncbi.nlm.nih.gov/pubmed/20458016
//Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association.
#Jung-2015 https://www.ncbi.nlm.nih.gov/pubmed/25310992
//Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan.
#Lei-2015 http://journal.frontiersin.org/article/10.3389/fphys.2015.00294/full
//Fine particulate matter in acute exacerbation of COPD.
#Hamra-2014 https://www.ncbi.nlm.nih.gov/pubmed/24911630
//Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis.
#Liu-2015 https://www.ncbi.nlm.nih.gov/pubmed/25913161
//Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation.
#Riva-2011 https://www.ncbi.nlm.nih.gov/pubmed/21506876
//Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice.
#Levesque-2011 https://www.ncbi.nlm.nih.gov/pubmed/21561831
//Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity.
#Morgan-2011 https://www.ncbi.nlm.nih.gov/pubmed/21724521
//Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro.
#Cheng-2010 http://www.tandfonline.com/doi/abs/10.1080/027868201753306714
//Chemical Composition of Aerosols from Kerosene Heaters Burning Jet Fuels.
#Ambroz-2016 https://www.ncbi.nlm.nih.gov/pubmed/27321041
//Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns.
#Balasubramanian-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402685/
//Differential effects of inhalation exposure to PM2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats.
#Lavicoli-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759935/
//The Effects of Nanomaterials as Endocrine Disruptors.
#Solt-2008 https://www.ncbi.nlm.nih.gov/pubmed/18349428
//Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults.
#Levesque-2013 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660420/
//The Role of MAC1 in Diesel Exhaust Particle-induced Microglial Activation and Loss of Dopaminergic Neuron Function
#Chao-2017 https://www.ncbi.nlm.nih.gov/pubmed/27539004
//Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus.
#Liu-2016 https://www.ncbi.nlm.nih.gov/pubmed/26580727
//The association of annual air pollution exposure with blood pressure among patients with sleep-disordered breathing.
#Bernatsky-2016 https://www.ncbi.nlm.nih.gov/pubmed/25988990
//Fine particulate air pollution, nitrogen dioxide, and systemic autoimmune rheumatic disease in Calgary, Alberta.
#Lu-2015 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782360/
//Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals
</biblio>


== Quotes ==
== License ==


* "During times of universal deceit, telling the truth becomes a revolutionary act." -- George Orwell (1984)
Copyright (C) 2012-2017 Etienne Robillard
* "We shall defend our island, whatever the cost may be, we shall fight on the beaches, we shall fight on the landing grounds, we shall fight in the fields and in the streets, we shall fight in the hills; we shall never surrender." -- Winston Churchill
* "It is no use saying, 'We are doing our best.' You have got to succeed in doing what is necessary." -- Winston Churchill
* "You have enemies? Good. That means you've stood up for something, sometime in your life." -- Winston Churchill
* "What kind of people do they think we are? Is it possible they do not realize that we shall never cease to persevere against them until they have been taught a lesson which they and the world will never forget?" -- Winston Churchill


== See also ==
Permission is granted to copy, distribute and/or modify this document
* [http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/otherendo/pineal.html Pineal Gland and Melatonin]
Under the terms of the GNU Free Documentation License, Version 1.3
* [http://www.biology.arizona.edu/biochemistry/problem_sets/aa/aa.html The Chemistry of Amino Acids]
or any later version published by the Free Software Foundation;
* [http://www.chem.ucalgary.ca/courses/351/Carey5th/Ch08/ch8-8.html Solvents Effects]
with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts.
* [http://toxsci.oxfordjournals.org/content/76/1/131/F1.large.jpg Fatty Acid Amide Hydrolase]
A copy of the license is included in the section entitled "GNU Free Documentation License".
* [http://faculty.ccbcmd.edu/courses/bio141/lecguide/unit4/antigens/antigens.html The Adaptive Immune System: Antigens]
* [http://pf11.blogspot.com/2010/03/zoonotic-h9n2-avian-influenza-further.html "The truth is in the sequences."]
* [http://en.wikiversity.org/wiki/Introduction_to_psychology/Consciousness Introduction to psychology: Consciousness]
* [http://www.naturalnews.com/034906_Bill_Gates_geo-engineering_chemtrails.html Bill Gates exposed for funding research, promotion of spraying geo-engineered 'chemtrails' across globe] (2012/02/08)
* [http://keith.seas.harvard.edu/FICER.html Fund for Innovative Climate and Energy Research]
* [http://killerspray.com/blog?post=Teen_SofiaXenidis_call2_action Sofia Xenidis Testimonial and Call for Actions]
----


{{LnNotebookRecentChanges2}}


__NOTOC__
== See you in space cowboy ==
<blockquote>
"I am free, no matter what rules surround me. If I find them tolerable, I tolerate them; if I find them too obnoxious, I break them.
I am free because I know that I alone am morally responsible for everything I do." -Robert A. Heinlein
</blockquote>
<blockquote>
"The essence of the independent mind lies not in what it thinks, but in how it thinks."
― Christopher Hitchens
</blockquote>
<blockquote>"Now let us consider another kind of drug – still undiscovered, but probably just around the corner – a drug capable of making people feel happy in situations where they would normally feel miserable. Such a drug would be a blessing, but a blessing fraught with grave political dangers. By making harmless chemical euphoria freely available, a dictator could reconcile an entire population to a state of affairs to which self-respecting human beings ought not to be reconciled. Despots have always found it necessary to supplement force by political or religious propaganda. In this sense the pen is mightier than the sword. But mightier than either the pen or the sword is the pill. In mental hospitals it has been found that chemical restraint is far more effective than strait jackets or psychiatry. The dictatorships of tomorrow will deprive men of their freedom, but will give them in exchange a happiness none the less real, as a subjective experience, for being chemically induced. The pursuit of happiness is one of the traditional rights of man; unfortunately, the achievement of happiness may turn out to be incompatible with another of man's rights – liberty." - Aldous Huxley
</blockquote>


__NOTOC__
<blockquote>"Under our noses, over our heads, hidden in plain [https://www.reddit.com/r/chemtrails/comments/609s8u/experimental_evidences_linking_clandestine/ sight]..." - Anonymous</blockquote>

Revision as of 02:58, 27 March 2017

Work-in-progress.

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Customize your entry pages <html><img src="/images/a/aa/Help.png" border="0" /></html>


Recently Edited Notebook Pages

Hypothesis

1. Unilateral/clandestine geoengineering activity is a source of air pollution/particulate matter. (PM2.5)

2. The molecular toxicity of PM2.5 is poorly understood.

3. The nanotoxicity, neurotoxicity, and genotoxicity of PM2.5 exposure on human health requires further investigations.

4. The differential effects of chronic PM2.5 exposure on the neuroimmune system, lung/brain axis, chronic inflammation, and neurodegenerative disorders (Alzheimer, Parkinson) requires additional research. [1]

5. MAC1/Glutaminase activation is implicated in the microglia-mediated dopaminergic neurotoxicity of PM2.5. [2][3]

Differential effects of nanoparticles translocation

Cardiovascular system

  • Effects of particulate matter (PM2.5) air pollution on cardiovascular diseases. [4]
    • Increase in blood pressure (hypertension) [5]
    • The association of annual air pollution exposure with blood pressure among patients with sleep-disordered breathing. [6]
  • Dysregulation of miRNA expression levels. [7]

Central nervous system

  • Alzheimer disease [8][2]
  • Parkinson disease [2]
  • PM2.5 exposure may cause chronic neuroinflammation and oxidative stress. [9][3][10][11]
  • PM2.5 exposure may induce selective neurotoxicity through glutamatergic signaling and increase NMDA-induced excitotoxicity. [3][12]
  • Cyclooxygenase-2, interleukin-1beta, and CD14 signaling upregulation. [13]
  • Microglia-mediated dopaminergic neurotoxicity (Reactive microgliosis). [2]

Endocrine system

  • Decrease of serum testosterone levels [14]
  • Increase of serum estradiol levels [14]
  • Autoimmune disorders [15]

Limbic system

  • Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus. [16]

Lymphatic system

  • Lipid peroxidation and oxidative DNA/RNA damage. [17]

Respiratory system

  • AECOPD [9]
  • Lung cancer [18]

Nanotoxicity of aerosolized nanoparticles

Notes

Resources

Keywords

aerosol, bioaerosol, nanoparticles, aluminium oxide, particulate matter, PM2.5, gulf war syndrome, chronic neuroinflammation, vapor phase oxidation, hydrocarbons, barium, microglia, MAC1, monodisperse aerosol, drug delivery

Support this project

This project is entirely financed by personal donations. To support this project, use the following link to donate money via Paypal: https://paypal.me/EtienneRobillard

References

  1. [Gilmour-2004]

    Differential pulmonary inflammation and in vitro cytotoxicity of size-fractionated fly ash particles from pulverized coal combustion.

  2. [Levesque-2013]

    The Role of MAC1 in Diesel Exhaust Particle-induced Microglial Activation and Loss of Dopaminergic Neuron Function

  3. [Liu-2015]

    Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation.

  4. [Brook-2010]

    Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association.

  5. [Balasubramanian-2013]

    Differential effects of inhalation exposure to PM2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats.

  6. [Liu-2016]

    The association of annual air pollution exposure with blood pressure among patients with sleep-disordered breathing.

  7. [Lu-2015]

    Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals

  8. [Jung-2015]

    Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan.

  9. [Lei-2015]

    Fine particulate matter in acute exacerbation of COPD.

  10. [Riva-2011]

    Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice.

  11. [Levesque-2011]

    Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity.

  12. [Morgan-2011]

    Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro.

  13. [Solt-2008]

    Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults.

  14. [Lavicoli-2013]

    The Effects of Nanomaterials as Endocrine Disruptors.

  15. [Bernatsky-2016]

    Fine particulate air pollution, nitrogen dioxide, and systemic autoimmune rheumatic disease in Calgary, Alberta.

  16. [Chao-2017]

    Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus.

  17. [Ambroz-2016]

    Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns.

  18. [Hamra-2014]

    Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis.

  19. [Herndon-2015]

    Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health

  20. [Herndon-2016]

    Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification.

  21. [Cheng-2010]

    Chemical Composition of Aerosols from Kerosene Heaters Burning Jet Fuels.

License

Copyright (C) 2012-2017 Etienne Robillard

Permission is granted to copy, distribute and/or modify this document Under the terms of the GNU Free Documentation License, Version 1.3 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled "GNU Free Documentation License".



See you in space cowboy

"I am free, no matter what rules surround me. If I find them tolerable, I tolerate them; if I find them too obnoxious, I break them. I am free because I know that I alone am morally responsible for everything I do." -Robert A. Heinlein

"The essence of the independent mind lies not in what it thinks, but in how it thinks." ― Christopher Hitchens

"Now let us consider another kind of drug – still undiscovered, but probably just around the corner – a drug capable of making people feel happy in situations where they would normally feel miserable. Such a drug would be a blessing, but a blessing fraught with grave political dangers. By making harmless chemical euphoria freely available, a dictator could reconcile an entire population to a state of affairs to which self-respecting human beings ought not to be reconciled. Despots have always found it necessary to supplement force by political or religious propaganda. In this sense the pen is mightier than the sword. But mightier than either the pen or the sword is the pill. In mental hospitals it has been found that chemical restraint is far more effective than strait jackets or psychiatry. The dictatorships of tomorrow will deprive men of their freedom, but will give them in exchange a happiness none the less real, as a subjective experience, for being chemically induced. The pursuit of happiness is one of the traditional rights of man; unfortunately, the achievement of happiness may turn out to be incompatible with another of man's rights – liberty." - Aldous Huxley

"Under our noses, over our heads, hidden in plain sight..." - Anonymous