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__TOC__


{{LnNotebookRecentChanges2}}


This is an experimental (and open to all) notebook dedicated in understanding the so-called "chemtrails" phenomenon from scratch.
__TOC__


The project is currently licensed under [http://www.gnu.org/copyleft/fdl.html GNU Free Documentation License Version 1.3].
== Hypothesis ==
1. Unilateral/clandestine geoengineering activity is a source of air pollution/particulate matter. ('''PM2.5''')


== License ==
2. The molecular toxicity of PM2.5 is poorly understood.


Copyright (C)  2012 Etienne Robillard
3. The nanotoxicity, neurotoxicity, and genotoxicity of PM2.5 exposure on human health requires further investigations.


Permission is granted to copy, distribute and/or modify this document
4. The differential effects of chronic PM2.5 exposure on the neuroimmune system, lung/brain axis, chronic inflammation, and neurodegenerative disorders (Alzheimer, Parkinson) requires additional research. <cite>Gilmour-2004</cite>
Under the terms of the GNU Free Documentation License, Version 1.3
or any later version published by the Free Software Foundation;
with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts.
A copy of the license is included in the section entitled "GNU Free Documentation License".


== Contents ==
5. MAC1/Glutaminase activation is implicated in the microglia-mediated dopaminergic neurotoxicity of PM2.5. <cite>Levesque-2013</cite><cite>Liu-2015</cite>


=== Introduction ===
== Differential effects of nanoparticles translocation ==
=== Cardiovascular system ===
* Effects of particulate matter (PM2.5) air pollution on cardiovascular diseases. <cite>Brook-2010</cite>
** Increase in blood pressure (hypertension) <cite>Balasubramanian-2013</cite>
** The association of annual air pollution exposure with blood pressure among patients with sleep-disordered breathing. <cite>Liu-2016</cite>
* Dysregulation of miRNA expression levels. <cite>Lu-2015</cite>


Has synthetic biology replaced modern eugenics ? This wiki suggests an attempt to discuss a
=== Central nervous system ===
story about eugenics in modern science or as generally referred to as the "chemtrails" phenomenon.
* Alzheimer disease <cite>Jung-2015</cite><cite>Levesque-2013</cite>
* Parkinson disease <cite>Levesque-2013</cite>
* PM2.5 exposure may cause chronic neuroinflammation and oxidative stress. <cite>Lei-2015</cite><cite>Liu-2015</cite><cite>Riva-2011</cite><cite>Levesque-2011</cite>
* PM2.5 exposure may induce selective neurotoxicity through glutamatergic signaling and increase NMDA-induced excitotoxicity. <cite>Liu-2015</cite><cite>Morgan-2011</cite>
* Cyclooxygenase-2, interleukin-1beta, and CD14 signaling upregulation. <cite>Solt-2008</cite>
* Microglia-mediated dopaminergic neurotoxicity (Reactive microgliosis). <cite>Levesque-2013</cite>


=== Abstract ===
=== Endocrine system ===
* Decrease of serum testosterone levels <cite>Lavicoli-2013</cite>
* Increase of serum estradiol levels <cite>Lavicoli-2013</cite>
* Autoimmune disorders <cite>Bernatsky-2016</cite>


Chemtrails is a recent phenomenon I started to observe around 2009.  
=== Limbic system ===
* Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus. <cite>Chao-2017</cite>


At this time I had very little knowledge about geoengineering or even
=== Lymphatic system ===
basic chemistry. I then started to familiarize myself with such phenomenons as they began to occupy further lines of
* Lipid peroxidation and oxidative DNA/RNA damage. <cite>Ambroz-2016</cite>
dissipated white lines across unaffected clouds. I then further observed the phenomenon, and noted down the dates
of such "phenomenons" taking guess on their physical attributes and noticed they were from man-operated aircrafts or some kind of cloaked
aerial origin. (geoengineering, synthetic biology)
WW2 (World war 2) was for me a couple of popular American movie scenes including films and other things dealing with Jews being intoxicated with
poisonous gas in concentration camps. I was not very interested in them and neither in the chemotherapy eugenic "science" which resulted in thousands
of deaths. (chemotherapy)


=== Synopsis ===
=== Respiratory system ===
* AECOPD <cite>Lei-2015</cite>
* Lung cancer <cite>Hamra-2014</cite>


* Welcome to the chemtrails scientific notebook version 1.0! In a modest attempt to document the perils of synthetic biology into concrete evidences of improper scientific practices, a fully human-managed reasoning machine should be developed to record and trace the origins of the chemtrails phenomenon to their respective offenders. Furthermore the development workflow should be based upon open access and documented into this wiki for easy publishing and maintenance.
== Nanotoxicity of aerosolized nanoparticles ==
* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/2014/12/14|Notebook]]


== Notes ==
* Condensation aerosols:
** [http://iopscience.iop.org/article/10.1070/RC1965v034n02ABEH001418/pdf Monodisperse aerosols]
* Coal-Based Jet Fuels:
** [http://www.energy.psu.edu/sites/default/files/files/JetFuels.pdf Advanced Thermally Stable Jet Fuels]
** [http://www.energy.psu.edu/sites/default/files/files/coalbased_jetfuel.pdf The Coal-Based Jet Fuel Program]
** [http://web.stanford.edu/group/pitsch/publication/ColketJet_Fuel_Surrogate_AIAA_2007.pdf Jet Fuel Surrogate Research]
** [https://dspace.mit.edu/handle/1721.1/9116 Catalytic combustion of methane with nanostructured barium hexaaluminate-based materials]
* Discussion:
** [http://www.thenakedscientists.com/forum/index.php?topic=68004 Do coal-based jet fuel (JP-900) emit ultrafine particles?]
** [http://www.thenakedscientists.com/forum/index.php?topic=67942 Is coal fly ash a synthetic compound?]
** [http://www.thenakedscientists.com/forum/index.php?topic=68555 Is reactive microgliosis a beneficial or harmful process?]
** [http://www.thenakedscientists.com/forum/index.php?topic=67302 Should we ban geoengineering?]
** [http://www.thenakedscientists.com/forum/index.php?topic=68061 What is the Gulf War syndrome?]
** [http://www.thenakedscientists.com/forum/index.php?topic=68101 What is a jet fuel surrogate?]
* Documentation:
** [https://en.wikipedia.org/wiki/Dodecane Dodecane (Wikipedia)]
** [https://en.wikipedia.org/wiki/Ethylbenzene Ethylbenzene (Wikipedia)]
** [http://www.ncbi.nlm.nih.gov/gene/2744 Glutaminase]
** [http://www.ncbi.nlm.nih.gov/pubmed/?term=gulf+war+syndrome Gulf War syndrome (PubMed search)]
** [https://en.wikipedia.org/wiki/Gulf_War_syndrome Gulf War syndrome (Wikipedia)]
** [https://en.wikipedia.org/wiki/Methylcyclohexane Methylcyclohexane (Wikipedia)]


== Resources ==
* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/Introduction|Introduction]]
* [[User:Etienne_Robillard/Notebook/Brainstorming|Brainstorming]]
* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/Model|Model]]
* [[User:Etienne_Robillard/Notebook/Photographic_evidences|Photographic evidences]]
* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/Research|Research]]


=== Credits ===
== Keywords ==
aerosol, bioaerosol, nanoparticles, aluminium oxide, particulate matter, PM2.5, gulf war syndrome, chronic neuroinflammation, vapor phase oxidation, hydrocarbons, barium, microglia, MAC1, monodisperse aerosol, drug delivery


TODO
== Support this project ==


=== History ===
This project is entirely financed by personal donations. To support this project, use the following link
to donate money via Paypal: https://paypal.me/EtienneRobillard


TODO
== References ==
<biblio>
#Herndon-2015 http://www.mdpi.com/1660-4601/12/8/9375/htm
//Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health
#Herndon-2016 http://nuclearplanet.com/frontiers1.pdf
//Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification.
#Gilmour-2004 https://www.ncbi.nlm.nih.gov/pubmed/15061611
//Differential pulmonary inflammation and in vitro cytotoxicity of size-fractionated fly ash particles from pulverized coal combustion.
#Brook-2010 https://www.ncbi.nlm.nih.gov/pubmed/20458016
//Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association.
#Jung-2015 https://www.ncbi.nlm.nih.gov/pubmed/25310992
//Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan.
#Lei-2015 http://journal.frontiersin.org/article/10.3389/fphys.2015.00294/full
//Fine particulate matter in acute exacerbation of COPD.
#Hamra-2014 https://www.ncbi.nlm.nih.gov/pubmed/24911630
//Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis.
#Liu-2015 https://www.ncbi.nlm.nih.gov/pubmed/25913161
//Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation.
#Riva-2011 https://www.ncbi.nlm.nih.gov/pubmed/21506876
//Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice.
#Levesque-2011 https://www.ncbi.nlm.nih.gov/pubmed/21561831
//Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity.
#Morgan-2011 https://www.ncbi.nlm.nih.gov/pubmed/21724521
//Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro.
#Cheng-2010 http://www.tandfonline.com/doi/abs/10.1080/027868201753306714
//Chemical Composition of Aerosols from Kerosene Heaters Burning Jet Fuels.
#Ambroz-2016 https://www.ncbi.nlm.nih.gov/pubmed/27321041
//Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns.
#Balasubramanian-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402685/
//Differential effects of inhalation exposure to PM2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats.
#Lavicoli-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759935/
//The Effects of Nanomaterials as Endocrine Disruptors.
#Solt-2008 https://www.ncbi.nlm.nih.gov/pubmed/18349428
//Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults.
#Levesque-2013 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660420/
//The Role of MAC1 in Diesel Exhaust Particle-induced Microglial Activation and Loss of Dopaminergic Neuron Function
#Chao-2017 https://www.ncbi.nlm.nih.gov/pubmed/27539004
//Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus.
#Liu-2016 https://www.ncbi.nlm.nih.gov/pubmed/26580727
//The association of annual air pollution exposure with blood pressure among patients with sleep-disordered breathing.
#Bernatsky-2016 https://www.ncbi.nlm.nih.gov/pubmed/25988990
//Fine particulate air pollution, nitrogen dioxide, and systemic autoimmune rheumatic disease in Calgary, Alberta.
#Lu-2015 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782360/
//Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals
</biblio>


=== Subtopics ===
== License ==


==== Orthogonal and potentially harmful drug delivery evidences involving unidentified chemical inducers and repeated exposure ====
Copyright (C)  2012-2017 Etienne Robillard


Notes (MAP/EGFR kinase related):
Permission is granted to copy, distribute and/or modify this document
* Important secondary messengers: NMDA, Dopamine, Serotonin, GABA, ACh, Tyrosine, calmodulin, p38 MAP kinase
Under the terms of the GNU Free Documentation License, Version 1.3
* '''MEK''' - an important Serine/Threonine protease in [http://openwetware.org/wiki/User:Etienne_Robillard/Notebook/Chemtrails911_notebook/Imidazole Imidazole] - a (Receptor associated)Tyrosine Kinase Inhibitor like agent possibly implicated in long-term neuronal depression
or any later version published by the Free Software Foundation;
* [http://openwetware.org/wiki/User:Etienne_Robillard/Notebook/Chemtrails911_notebook/BCTP BCTP]
with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts.
A copy of the license is included in the section entitled "GNU Free Documentation License".


Mitogen-Activated Protein kinase:
* Sites of interests: p38 (MEK), EGFR (Fyn), c-Src domain (brain/hippocampus/amygdala), Ras (FTase, MAP) kinase inhibitors (MEK related?) 
* Long term effects of experimental chemical promoter/repressor Z on cell division and duplication ?
* '''Delta9-THC''' (anandamide?) mediated neurotransmitter synthesis: Hippocampus/Amygdala b-amyloid cleaving ? (GABA intermediate messenger/AChe link..?) ?
* Key roles for nanoparticles based chemical inducers and repressors are multiples and under intense research including but not limited to chemotherapy and bioinformatics.


==== Asymmetric and unconventional human experimental trials on unwary citizens are scientifically irresponsible, potentially harmful, cancerogenic, mutagenic, rogue, hostile, uncivilized, and ruthless acts of murdering made by fanatics club armed with sophisticated bioweapons. ====
__NOTOC__


Thanks for reading this far. This topic may be a little broad and require some refactoring.
== See you in space cowboy ==


Goal(s): xxx
<blockquote>
"I am free, no matter what rules surround me. If I find them tolerable, I tolerate them; if I find them too obnoxious, I break them.
I am free because I know that I alone am morally responsible for everything I do." -Robert A. Heinlein
</blockquote>


Genes/protein:
<blockquote>
* [[/EGFR|Epidermal Growth Factor Receptor (Protein)]]: A key membrane for targeted drug delivery, chemotherapy and perhaps tyrosine kinase protein blocking in '''MAJOR GROUPS''' of '''HUMANS populations''' possessing the '''EGF''' gene...  
"The essence of the independent mind lies not in what it thinks, but in how it thinks."
* [[/CYP3A4|CYP3A4 (Protein-coding gene)]]
― Christopher Hitchens
</blockquote>


Cancer therapy drugs :
<blockquote>"Now let us consider another kind of drug – still undiscovered, but probably just around the corner – a drug capable of making people feel happy in situations where they would normally feel miserable. Such a drug would be a blessing, but a blessing fraught with grave political dangers. By making harmless chemical euphoria freely available, a dictator could reconcile an entire population to a state of affairs to which self-respecting human beings ought not to be reconciled. Despots have always found it necessary to supplement force by political or religious propaganda. In this sense the pen is mightier than the sword. But mightier than either the pen or the sword is the pill. In mental hospitals it has been found that chemical restraint is far more effective than strait jackets or psychiatry. The dictatorships of tomorrow will deprive men of their freedom, but will give them in exchange a happiness none the less real, as a subjective experience, for being chemically induced. The pursuit of happiness is one of the traditional rights of man; unfortunately, the achievement of happiness may turn out to be incompatible with another of man's rights – liberty." - Aldous Huxley
* [[/Paclitaxel|Paclitaxel (Drug)]]:  Compare this with doxorubicin; non EGF(R)-specific (?);
</blockquote>
* [[/Docetaxel|Docetaxel (Drug)]]: A generic paclitaxel molecule used for targeted cancer therapy; Can be combined with Doxorubicin for advanced chemotherapy uses.  
** Thus is Docetaxel classifiable as a DNA Topoisomerase II inhibitor drug '''regulating''' cell-dependent mitosis?
* [[/Doxorubicin|Doxorubicin (Drug)]]: A anti-malaria (?) drug with EGF(R)-specific binding;
* [[/Imatinib (Drug)]]: A tyrosine kinase inhibitor drug designed by Novartis. Like Doxorubicin, may produces side effects including skin rashes and headaches. In addition, may also inhibit aCh(R) (acetylcholinesterase) and modulate ATP (adenosine tryphosphate) synthase inside the mitochondria membrane, suggesting Imatinib could have a potential role in regulating neurotransmitter regulation (calmodulin, GABA, etc). However it is unknown at this time if a generic version of this drug could deliver ATP mediated energy payload to epithelial cells from EGFR over-expressed phospholipid (ie: cholesterol). A suggested hypothesis is thus to assert the drug delivery factors of aCh derived receptors associated specifically to EGFR binding site in Alzheimer disease and related ATP based ligands. [Keywords: Imatinib, Alzheimer, ATP, Brain, aChr, calmodulin, EGFR, breast cancer, GABA, Glutamate, Glycine, Tyrosine, Adenosine, NMDA, Serotonin, [http://www.sciencedaily.com/releases/2007/12/071203190607.htm Liposome]]


==== Predicting the role of competent cells in irreversible morphogenesis of highly pathogenic Anthrax strain: Science-fiction or red heering? ====
<blockquote>"Under our noses, over our heads, hidden in plain [https://www.reddit.com/r/chemtrails/comments/609s8u/experimental_evidences_linking_clandestine/ sight]..." - Anonymous</blockquote>
 
In other words, has "Synthia" been invited by fanatics to participate in a organized molecular hijack of the MAP kinase pathway
to produce high-quality Anthrax spores ?
 
Therefore to confirm "Synthia" as a prime suspect in this organized murdering scheme, understanding the regulation of the MAP kinase protein
is fundamental to hypothesize the role and implications of competent cells in Anthrax [http://academic.brooklyn.cuny.edu/biology/bio4fv/page/endocyta.htm endocytosis]. [http://www.ks.uiuc.edu/Research/anthrax/ 1]
 
===== So, is the aerosol agent a gold standard in '''restriction endonucleases based''' recombinant vaccine? =====
 
"Battelle, as a CIA contractor, partnered with Bioport for America's sole anthrax vaccine production. Bioport-largely owned by Britain's top secret biowarfare consortium PortonDown, '''bin Laden family associate [http://investors.emergentbiosolutions.com/phoenix.zhtml?c=202582&p=irol-govBio&ID=158319 Faud El Hibri]''', Admiral William J. Crowe, Jr., a former Chairman of the Joint Chiefs of Staff, and others (including, according to some investigators, the multinational investment firm and defense contractor, the Carlyle Management Group, that managed bin Laden family millions prior to 9-11, directed by past CIA director Frank Carlucci, James Baker III (->), and Past President George H.W. Bush);" [http://www.911review.org/Sept11Wiki/Battelle.shtml 2]
 
===== Okay! So where is Scooby Doo now, Mr. triple Dealer Spy ? =====
 
"For instance, Hatfill allegedly said that anyone who knew "how to grow anthrax spores of one to '''three microns''' had to know that the hole in an envelope is '''10 microns''' and that the spores would escape." [http://cryptome.org/is-z-hatfill.htm 3]
 
 
 
 
[[Category: CanadaInDistressCategory DeathOfEvidenceCategory]]
 
== Quotes ==
 
* "During times of universal deceit, telling the truth becomes a revolutionary act." -- George Orwell (1984)
* "We have now sunk to a depth at which restatement of the obvious is the first duty of intelligent men." -- George Orwell
* "We shall defend our island, whatever the cost may be, we shall fight on the beaches, we shall fight on the landing grounds, we shall fight in the
 
fields and in the streets, we shall fight in the hills; we shall never surrender." -- Winston Churchill
* "It is no use saying, 'We are doing our best.' You have got to succeed in doing what is necessary." -- Winston Churchill
* "You have enemies? Good. That means you've stood up for something, sometime in your life." -- Winston Churchill
* "What kind of people do they think we are? Is it possible they do not realize that we shall never cease to persevere against them until they have been taught a lesson which they and the world will never forget?" -- Winston Churchill
 
* [http://openwetware.org/images/6/66/Science_in_the_city_2-02.png "All free men, wherever they may live, are citizens of Berlin. And therefore, as a free man, I take pride in the words "Ich bin ein Berliner!" -- John F. Kennedy]
 
* "A central lesson of science is that to understand complex issues (or even simple ones), we must try to free our minds of dogma and to guarantee the freedom to publish, to contradict, and to experiment. Arguments from authority are unacceptable." -- Carl Sagan
 
== Multimedia ==
 
===  Death of Evidences: Aerosol-based germ warfare may have voided the Quebec Charter of Rights and Freedoms committing wide-scale  climatic and pharmacological experiments over unaware and disinformed human populations.  ===
 
* Molecular basics of Alzheimer Disease: https://www.youtube-nocookie.com/embed/6LlgryA7QxY
* Amygdala hijacking https://www.youtube-nocookie.com/embed/YM3cXZ7CFls
 
=== Cloud Galleries ===
* Get cool Cloud Pictures From Bing: http://bing.com/
 
== See also ==
 
Biology:
* [http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/otherendo/pineal.html Pineal Gland and Melatonin]
* [http://www.chem.ucalgary.ca/courses/351/Carey5th/Ch08/ch8-8.html Solvents Effects]
* [http://www.medwelljournals.com/fulltext/?doi=javaa.2011.1895.1900 Modes of Action of Probiotics: Recent Developments]
* Amino acids: 
** [http://faculty.ccbcmd.edu/courses/bio141/lecguide/unit4/antigens/antigens.html The Adaptive Immune System: Antigens]
** [http://www.biology.arizona.edu/biochemistry/problem_sets/aa/aa.html The Chemistry of Amino Acids]
** [http://toxsci.oxfordjournals.org/content/76/1/131/F1.large.jpg Fatty Acid Amide Hydrolase]
* Genetic acquisitions of synthetic like antigens (ie: vaccine escape evidences)
** [http://pf11.blogspot.com/2010/03/zoonotic-h9n2-avian-influenza-further.html "The truth is in the sequences."]
** [http://www.lewrockwell.com/sardi/sardi133.html Why Isn't the H1N1 Pandemic Flu Being Investigated as a Designed Bioweapon?]
** [http://anthro.palomar.edu/mendel/mendel_3.htm Basic Principles of Genetics: Exceptions to Simple Inheritance] (non-Mendelian inheritance)
** [http://www.mendeley.com/research/highly-pathogenic-avian-influenza-virus-h5n1-egypt-escapes-vaccineinduced-immunity-confers-clinical-protection-against-heterologous-clade-22-1-egyptian-isolate/ Highly pathogenic avian influenza virus H5N1 from Egypt escapes vaccine-induced immunity but confers clinical protection against a heterologous clade 2.2.1 Egyptian isolate.]
 
Synthetic Biology:
* [http://www.organicconsumers.org/articles/article_20878.cfm ETC Group calls for Global Moratorium on Synthetic Biology]
 
Peoples:
* [http://keith.seas.harvard.edu/FICER.html Fund for Innovative Climate and Energy Research]
* [http://caseclosedbylewweinstein.wordpress.com/2009/06/28/tracking-dr-ivins%E2%80%99-rmr-1029-anthrax-more-questions-for-um-and-lsu-researchers/ tracking Dr. Ivins’ RMR-1029 anthrax; more questions for UM and LSU researchers]
** [http://caseclosedbylewweinstein.wordpress.com/2012/05/09/april-2012-fbi-quantico-publication-the-detection-of-meglumine-and-diatrizoate-in-the-mailed-anthrax-in-no-way-pointed-to-bruce-ivins-as-the-perpetrator-or-involved-at-all-meglumine-and-diatrizo/ April 26, 2012 FBI Quantico Publication: The Detection of Meglumine and Diatrizoate In No Way Pointed To Bruce Ivins As The Perpetrator Or Involved At All; Meglumine and Diatrizoate were both detected in the USAMRIID RMR 1029 sample — but '''Meglumine and Diatrizoate were NOT detected in the 2001 letter''' spore evidence]
* [http://cns.miis.edu/wmdjunction/110822_fbi_anthrax.htm New Questions About the FBI's Anthrax Case: Valid Concerns or Red Herring?]
* [http://usasurvival.org/ck03.25.10.html Obama Obstructs Oversight of FBI in Anthrax Case]
* [http://killerspray.com/blog?post=Teen_SofiaXenidis_call2_action Sofia Xenidis Testimonial and Call for Actions]
 
Wikipedia:
* [http://en.wikiversity.org/wiki/Introduction_to_psychology/Consciousness Introduction to psychology: Consciousness]
 
Recent news:
* [http://www.deathofevidence.ca/ Celebrating the Death Of Evidence in Canada Scientific Research Funds: No science, no evidence, no truth, no democracy]
 
* [http://www.nature.com/news/remote-controlled-genes-trigger-insulin-production-1.10585 Remote-controlled genes trigger insulin production]
** [[User:Etienne Robillard|Etienne Robillard]] 07:18, 5 May 2012 (EDT): Whoa, calmodulin mediated signal transduction using fat-soluble nanoparticles aggregating to tumor cells in a "controlled/directed" process using heat/light energy as the master switch for tyrosine kinase II to induce or inhibit (auto)phosphorylation of pTyr residues?
* [http://www.naturalnews.com/034906_Bill_Gates_geo-engineering_chemtrails.html Bill Gates exposed for funding research, promotion of spraying geo-engineered 'chemtrails' across globe], 2012/02/08
* [http://www.crainsdetroit.com/article/20110803/FREE/110809957 NanoBio gets license from agency to develop vaccine to fight respiratory syncytial virus infections], 2011/08/03
* [http://www.sciencedaily.com/releases/2010/09/100930142727.htm Microbes Engineered for Low-Cost Production of '''Anti-Cancer''' Drug, Taxol], 2010
* [http://www.azonano.com/news.aspx?newsID=15165 GSK and NanoBio Signs Exclusive Over-the-Counter Licensing Agreement for Nanoemulsion Treatment], 2009/12/16
* [http://www.schizophreniaforum.org/new/detail.asp?id=1413 Does Oxidative Stress Link NMDA and GABA Hypotheses of Schizophrenia?] ([http://www.sciencedirect.com/science/article/pii/S0304394008010197 Study]), 2007/12/09
* [http://phys.org/news7764.html Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates], 2005/11/01
* [http://www.thefreelibrary.com/BattellePharma+to+Present+At+Respiratory+Drug+Delivery+VIII...-a085494227 BattellePharma to Present At Respiratory Drug Delivery VIII Conference.], 2002/05/07
* [http://www.nytimes.com/2001/09/04/world/us-germ-warfare-research-pushes-treaty-limits.html U.S. Germ Warfare Research Pushes Treaty Limits], 2001/09/04
 
 
 
----
 
{{LnNotebookRecentChanges2}}
 
 
__NOTOC__

Revision as of 02:58, 27 March 2017

Work-in-progress.

<sitesearch>title=Search this Project</sitesearch>

Customize your entry pages <html><img src="/images/a/aa/Help.png" border="0" /></html>


Recently Edited Notebook Pages

Hypothesis

1. Unilateral/clandestine geoengineering activity is a source of air pollution/particulate matter. (PM2.5)

2. The molecular toxicity of PM2.5 is poorly understood.

3. The nanotoxicity, neurotoxicity, and genotoxicity of PM2.5 exposure on human health requires further investigations.

4. The differential effects of chronic PM2.5 exposure on the neuroimmune system, lung/brain axis, chronic inflammation, and neurodegenerative disorders (Alzheimer, Parkinson) requires additional research. [1]

5. MAC1/Glutaminase activation is implicated in the microglia-mediated dopaminergic neurotoxicity of PM2.5. [2][3]

Differential effects of nanoparticles translocation

Cardiovascular system

  • Effects of particulate matter (PM2.5) air pollution on cardiovascular diseases. [4]
    • Increase in blood pressure (hypertension) [5]
    • The association of annual air pollution exposure with blood pressure among patients with sleep-disordered breathing. [6]
  • Dysregulation of miRNA expression levels. [7]

Central nervous system

  • Alzheimer disease [8][2]
  • Parkinson disease [2]
  • PM2.5 exposure may cause chronic neuroinflammation and oxidative stress. [9][3][10][11]
  • PM2.5 exposure may induce selective neurotoxicity through glutamatergic signaling and increase NMDA-induced excitotoxicity. [3][12]
  • Cyclooxygenase-2, interleukin-1beta, and CD14 signaling upregulation. [13]
  • Microglia-mediated dopaminergic neurotoxicity (Reactive microgliosis). [2]

Endocrine system

  • Decrease of serum testosterone levels [14]
  • Increase of serum estradiol levels [14]
  • Autoimmune disorders [15]

Limbic system

  • Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus. [16]

Lymphatic system

  • Lipid peroxidation and oxidative DNA/RNA damage. [17]

Respiratory system

  • AECOPD [9]
  • Lung cancer [18]

Nanotoxicity of aerosolized nanoparticles

Notes

Resources

Keywords

aerosol, bioaerosol, nanoparticles, aluminium oxide, particulate matter, PM2.5, gulf war syndrome, chronic neuroinflammation, vapor phase oxidation, hydrocarbons, barium, microglia, MAC1, monodisperse aerosol, drug delivery

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References

  1. https://www.ncbi.nlm.nih.gov/pubmed/15061611

    [Gilmour-2004]

    Differential pulmonary inflammation and in vitro cytotoxicity of size-fractionated fly ash particles from pulverized coal combustion.

  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660420/

    [Levesque-2013]

    The Role of MAC1 in Diesel Exhaust Particle-induced Microglial Activation and Loss of Dopaminergic Neuron Function

  3. https://www.ncbi.nlm.nih.gov/pubmed/25913161

    [Liu-2015]

    Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation.

  4. https://www.ncbi.nlm.nih.gov/pubmed/20458016

    [Brook-2010]

    Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association.

  5. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402685/

    [Balasubramanian-2013]

    Differential effects of inhalation exposure to PM2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats.

  6. https://www.ncbi.nlm.nih.gov/pubmed/26580727

    [Liu-2016]

    The association of annual air pollution exposure with blood pressure among patients with sleep-disordered breathing.

  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782360/

    [Lu-2015]

    Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals

  8. https://www.ncbi.nlm.nih.gov/pubmed/25310992

    [Jung-2015]

    Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan.

  9. http://journal.frontiersin.org/article/10.3389/fphys.2015.00294/full

    [Lei-2015]

    Fine particulate matter in acute exacerbation of COPD.

  10. https://www.ncbi.nlm.nih.gov/pubmed/21506876

    [Riva-2011]

    Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice.

  11. https://www.ncbi.nlm.nih.gov/pubmed/21561831

    [Levesque-2011]

    Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity.

  12. https://www.ncbi.nlm.nih.gov/pubmed/21724521

    [Morgan-2011]

    Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro.

  13. https://www.ncbi.nlm.nih.gov/pubmed/18349428

    [Solt-2008]

    Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults.

  14. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759935/

    [Lavicoli-2013]

    The Effects of Nanomaterials as Endocrine Disruptors.

  15. https://www.ncbi.nlm.nih.gov/pubmed/25988990

    [Bernatsky-2016]

    Fine particulate air pollution, nitrogen dioxide, and systemic autoimmune rheumatic disease in Calgary, Alberta.

  16. https://www.ncbi.nlm.nih.gov/pubmed/27539004

    [Chao-2017]

    Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus.

  17. https://www.ncbi.nlm.nih.gov/pubmed/27321041

    [Ambroz-2016]

    Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns.

  18. https://www.ncbi.nlm.nih.gov/pubmed/24911630

    [Hamra-2014]

    Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis.

  19. http://www.mdpi.com/1660-4601/12/8/9375/htm

    [Herndon-2015]

    Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health

  20. http://nuclearplanet.com/frontiers1.pdf

    [Herndon-2016]

    Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification.

  21. http://www.tandfonline.com/doi/abs/10.1080/027868201753306714

    [Cheng-2010]

    Chemical Composition of Aerosols from Kerosene Heaters Burning Jet Fuels.

License

Copyright (C) 2012-2017 Etienne Robillard

Permission is granted to copy, distribute and/or modify this document Under the terms of the GNU Free Documentation License, Version 1.3 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled "GNU Free Documentation License".



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"Now let us consider another kind of drug – still undiscovered, but probably just around the corner – a drug capable of making people feel happy in situations where they would normally feel miserable. Such a drug would be a blessing, but a blessing fraught with grave political dangers. By making harmless chemical euphoria freely available, a dictator could reconcile an entire population to a state of affairs to which self-respecting human beings ought not to be reconciled. Despots have always found it necessary to supplement force by political or religious propaganda. In this sense the pen is mightier than the sword. But mightier than either the pen or the sword is the pill. In mental hospitals it has been found that chemical restraint is far more effective than strait jackets or psychiatry. The dictatorships of tomorrow will deprive men of their freedom, but will give them in exchange a happiness none the less real, as a subjective experience, for being chemically induced. The pursuit of happiness is one of the traditional rights of man; unfortunately, the achievement of happiness may turn out to be incompatible with another of man's rights – liberty." - Aldous Huxley

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