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Recently Edited Notebook Pages
Hypothesis
1. Unilateral/clandestine geoengineering activity is a source of air pollution/particulate matter. (PM2.5)
2. The molecular toxicity of PM2.5 is poorly understood.
3. The nanotoxicity and genotoxicity of PM2.5 nanoparticles on human health requires further investigations.
4. The differential effects of chronic PM2.5 exposure on the neuroimmune system, lung/brain axis, chronic inflammation, and neurodegenerative disorders (Alzheimer, Parkinson) requires additional research. [1]
5. MAC1/Glutaminase activation is implicated in the microglia-mediated dopaminergic neurotoxicity of PM2.5. [2][3]
Differential effects of nanoparticles translocation
Cardiovascular system
- Effects of particulate matter (PM2.5) air pollution on cardiovascular disease [4]
- Increase in blood pressure (hypertension) [5]
Central nervous system
- Alzheimer disease [6][2]
- Parkinson disease [2]
- PM2.5 exposure may cause chronic neuroinflammation and oxidative stress. [7][3][8][9]
- PM2.5 exposure may induce selective neurotoxicity through glutamatergic signaling and increase NMDA-induced excitotoxicity. [3][10]
- Cyclooxygenase-2, interleukin-1beta, and CD14 signaling upregulation. [11]
- Microglia-mediated dopaminergic neurotoxicity (Reactive microgliosis). [2]
Endocrine system
- Decrease of serum testosterone levels [12]
- Increase of serum estradiol levels [12]
- Chronic fatigue syndrome (CFS) (Reference needed)
Lymphatic system
- Lipid peroxidation and oxidative DNA/RNA damage. [13]
Respiratory system
- AECOPD [7]
- Lung cancer [14]
Nanotoxicity of aerosolized nanoparticles
Notes
- Condensation aerosols:
- Coal-Based Jet Fuels:
- Discussion:
- Documentation:
Resources
Keywords
aerosol, bioaerosol, nanoparticles, aluminium oxide, particulate matter, PM2.5, gulf war syndrome, chronic neuroinflammation, vapor phase oxidation, hydrocarbons, barium, microglia, MAC1, monodisperse aerosol, drug delivery
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References
- [Gilmour-2004]
Differential pulmonary inflammation and in vitro cytotoxicity of size-fractionated fly ash particles from pulverized coal combustion. |
- [Levesque-2013]
The Role of MAC1 in Diesel Exhaust Particle-induced Microglial Activation and Loss of Dopaminergic Neuron Function |
- [Liu-2015]
Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation. |
- [Brook-2010]
Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. |
- [Balasubramanian-2013]
Differential effects of inhalation exposure to PM2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats. |
- [Jung-2015]
Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan. |
- [Lei-2015]
Fine particulate matter in acute exacerbation of COPD. |
- [Riva-2011]
Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice. |
- [Levesque-2011]
Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity. |
- [Morgan-2011]
Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro. |
- [Solt-2008]
Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults. |
- [Lavicoli-2013]
The Effects of Nanomaterials as Endocrine Disruptors. |
- [Ambroz-2016]
Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns. |
- [Hamra-2014]
Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis. |
- [Herndon-2015]
Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health |
- [Herndon-2016]
Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification. |
- [Cheng-2010]
Chemical Composition of Aerosols from Kerosene Heaters Burning Jet Fuels. |
License
Copyright (C) 2012-2016 Etienne Robillard
Permission is granted to copy, distribute and/or modify this document
Under the terms of the GNU Free Documentation License, Version 1.3
or any later version published by the Free Software Foundation;
with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts.
A copy of the license is included in the section entitled "GNU Free Documentation License".
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