User:Tkadm30/Notebook/chim trills notebook/Research

Research topics

Translocation and internalization of metal oxide nanoparticles (PM2.5)

• Aluminium-induced neurotoxicity and chronic neuroinflammation in the microglia
• Translocation of PM2.5 to the brain.
• The Effects of Nanomaterials as Endocrine Disruptors.

Translocation of aluminium oxide nanoparticles in the microglia

• Glia activation induced by peripheral administration of aluminum oxide nanoparticles in rat brains

Nanotoxicity of metal oxide nanoparticles exposure

• The immunological nanotoxicity of fine particulate matter (PM2.5) is under investigation.
• The chemical clumping behavior of PM2.5 require a sophisticated mechanical delivery system.
• The synthetic nature of PM2.5 require further research.

Characterization of the Gulf War Syndrome

The pathology of the Gulf War syndrome (GWS) is not well characterized: The immunotoxicity and nanotoxicity of metal oxides nanoparticles require further research to validate the role of nanomaterials exposure in the pathology of GWS/CFS.

Epidemiological evidences of PM2.5 damage to neuroimmune system:

• Alteration of cytokines production
• Inflammation
• Oxidative stress (Aluminium oxide)
• Microglial activation?
• Decrease in neurotrophin expression
• Modulation of neuroendocrine response

Nanotoxicity of metal oxides nanoparticles:

• Aluminium oxide nanoparticles may induce proinflammatory response and oxidative stress.

Further readings:

• The neuroendocrinology of chronic fatigue syndrome.

Nanoparticle-based drug delivery

Translocation and internalization of NPs:

• Synthetic nucleic acid delivery systems
• Engineered nanoparticles can be developed to enter blood-brain barrier through intracellular (siRNA) delivery.
• Cellular internalization of quantum dots.

Aerosolized drug nanoparticles

• Photoactivated drug delivery vectors
• Monodisperse aerosols

Research projects

Differential effects of drug nanoparticles on the neuroimmune system and microglial cells

I aim to understand the nanotoxicity and genotoxicity of long-term PM2.5 exposure on physiological and neurological processes:

• In summary, I'm interested to understand the effects of nanoparticles on chronic pulmonary diseases (COPD), DNA/RNA and NADPH dysregulation.
• The differential effects of drug nanoparticles on chronic neuroinflammation and microglial activation (reactive microgliosis) require further research.

Keywords: metal oxides, nanoparticles, bioaerosol, drug delivery, CNS, neuroinflammation, microglia, PM2.5

Knowledge is power: Psychology of modern psychochemical warfare.

Clandestine geoengineering activity is poorly understood. The aim of this research project is to understand how cognitive infiltration is used to deter scientific research on PM2.5 nanotoxicity.

Keywords: psychology, consciousness, psychochemicals, science, deception, media blackout, cognitive dissonance, disinformation, cognitive infiltration, troll, education, research, PM2.5

Death of evidences

The scientific evidences of clandestine geoengineering activity are ignored by the media. I'm interested in understanding why.