User:Tkadm30/Notebook/chim trills notebook/Research: Difference between revisions
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===Characterization of the Gulf War Syndrome=== | ===Characterization of the Gulf War Syndrome=== | ||
The pathology of the Gulf War syndrome (GWS) is not well characterized: The [http://www.ncbi.nlm.nih.gov/pubmed/21329568 immunotoxicity] and [http://www.geoengineeringwatch.org/documents/barron/Nanosized%20Aluminum%20Altered%20Immune%20Function.pdf nanotoxicity] of PM2.5 nanoparticles require further research to validate the effects of nanomaterials exposure in the pathology of GWS/CFS. | The pathology of the Gulf War syndrome (GWS) is not well characterized: The [http://www.ncbi.nlm.nih.gov/pubmed/21329568 immunotoxicity] and [http://www.geoengineeringwatch.org/documents/barron/Nanosized%20Aluminum%20Altered%20Immune%20Function.pdf nanotoxicity] of PM2.5 nanoparticles require further research to validate the effects of long-term nanomaterials exposure in the pathology of GWS/CFS. | ||
Epidemiological evidences of PM2.5 damage to '''neuroimmune''' system: | Epidemiological evidences of PM2.5 damage to '''neuroimmune''' system: |
Revision as of 04:14, 2 March 2017
Research topics
Translocation and internalization of metal oxide nanoparticles (PM2.5)
- Aluminium-induced neurotoxicity and chronic neuroinflammation in the microglia
- Translocation of PM2.5 to the brain.
- The Effects of Nanomaterials as Endocrine Disruptors.
Translocation of aluminium oxide nanoparticles in the microglia
Nanotoxicity and genotoxicity of drug nanoparticles exposure
- The immunological nanotoxicity and genotoxicity of fine particulate matter (PM2.5) is under investigation.
- The chemical clumping behavior of PM2.5 nanoparticles may require a ultrasonic atomization delivery system.
- The synthetic nature of PM2.5 require further research.
Characterization of the Gulf War Syndrome
The pathology of the Gulf War syndrome (GWS) is not well characterized: The immunotoxicity and nanotoxicity of PM2.5 nanoparticles require further research to validate the effects of long-term nanomaterials exposure in the pathology of GWS/CFS.
Epidemiological evidences of PM2.5 damage to neuroimmune system:
- Alteration of cytokines production
- Neuroinflammation
- Mitochondrial DNA (mtDNA) oxidative stress (Aluminium oxide?)
- Microglial activation markers? (MAC1)
- Decrease in neurotrophin expression
- Modulation of neuroendocrine response
Nanotoxicity of metal oxides nanoparticles:
- Aluminium oxide nanoparticles may induce proinflammatory response and oxidative stress.
Further readings:
Nanoparticle-based drug delivery
Translocation and internalization of NPs:
- Synthetic nucleic acid delivery systems
- Engineered nanoparticles can be developed to enter blood-brain barrier through intracellular (siRNA) delivery.
- Cellular internalization of quantum dots.
Aerosolized drug nanoparticles
- Photoactivated drug delivery vectors
- Monodisperse aerosols
Research projects
Differential effects of drug nanoparticles on the neuroimmune system and microglial cells
I aim to understand the nanotoxicity and genotoxicity of long-term PM2.5 exposure on physiological and neurological processes:
- In summary, I'm interested to understand the effects of nanoparticles on chronic pulmonary diseases (COPD), DNA/RNA and NADPH dysregulation.
- The differential effects of drug nanoparticles on chronic neuroinflammation and microglial activation (reactive microgliosis) require further research.
Keywords: metal oxides, nanoparticles, bioaerosol, drug delivery, CNS, neuroinflammation, microglia, PM2.5
Knowledge is power: Psychology of modern psychochemical warfare.
Clandestine geoengineering activity is a controversial issue. The aim of this research project is to understand how artificial intelligence is used to deter scientific research on PM2.5.
Keywords: psychology, consciousness, psychochemicals, science, deception, media blackout, cognitive dissonance, disinformation, cognitive infiltration, education, research, PM2.5