User:Federico Castro M/Projects/VSFH: Difference between revisions
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(Data: RNA genome size limit.) |
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Concivably an organism could survive in a controlled environment with a minimal genome of just 113kbp and 151 genes ([http://www.nature.com/msb/journal/v2/n1/full/msb4100090.html Forster 2006]). However, recent estimates sugest that LUCA was complex and probably had more than 600 genes ([http://www.informatics.sussex.ac.uk/users/ctf20/dphil_2005/CSNs/Minimal%20Genome/nrmicro751.pdf Kooning 2003]). | Concivably an organism could survive in a controlled environment with a minimal genome of just 113kbp and 151 genes ([http://www.nature.com/msb/journal/v2/n1/full/msb4100090.html Forster 2006]). However, recent estimates sugest that LUCA was complex and probably had more than 600 genes ([http://www.informatics.sussex.ac.uk/users/ctf20/dphil_2005/CSNs/Minimal%20Genome/nrmicro751.pdf Kooning 2003]). | ||
* Check if a RNA genome can sustain such genome size. | * Check if a RNA genome can sustain such genome size. | ||
RNA is much more error-prone than DNA due to its higher mutation rate, so that RNA molecules cannot exceed certain size (Eigen limit) without falling into replicative catastrophe. ([http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129678/?tool=pubmed Eigen 2002]) | |||
* Does it had the necesary genetic machinery to support DNA? | * Does it had the necesary genetic machinery to support DNA? | ||
Revision as of 13:30, 10 November 2009
This project is about designing an organism that resembles the Last Universal Common Ancestor and whose construction is feasible.
Replication machinery
We have to start by:
- Estimate the genomic size of LUCA.
Concivably an organism could survive in a controlled environment with a minimal genome of just 113kbp and 151 genes (Forster 2006). However, recent estimates sugest that LUCA was complex and probably had more than 600 genes (Kooning 2003).
- Check if a RNA genome can sustain such genome size.
RNA is much more error-prone than DNA due to its higher mutation rate, so that RNA molecules cannot exceed certain size (Eigen limit) without falling into replicative catastrophe. (Eigen 2002)
- Does it had the necesary genetic machinery to support DNA?
Atte (membrillo): Wweww Desde Xicotencatl Tlalpan, translate this Google :)
