User:Federico Castro M/Projects/VSFH

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(Data: RNA genome size limit.)
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Concivably an organism could survive in a controlled environment with a minimal genome of just 113kbp and 151 genes ([http://www.nature.com/msb/journal/v2/n1/full/msb4100090.html Forster 2006]). However, recent estimates sugest that LUCA was complex and probably had more than 600 genes ([http://www.informatics.sussex.ac.uk/users/ctf20/dphil_2005/CSNs/Minimal%20Genome/nrmicro751.pdf Kooning 2003]).
Concivably an organism could survive in a controlled environment with a minimal genome of just 113kbp and 151 genes ([http://www.nature.com/msb/journal/v2/n1/full/msb4100090.html Forster 2006]). However, recent estimates sugest that LUCA was complex and probably had more than 600 genes ([http://www.informatics.sussex.ac.uk/users/ctf20/dphil_2005/CSNs/Minimal%20Genome/nrmicro751.pdf Kooning 2003]).
* Check if a RNA genome can sustain such genome size.
* Check if a RNA genome can sustain such genome size.
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RNA is much more error-prone than DNA due to its higher mutation rate, so that RNA molecules cannot exceed certain size (Eigen limit) without falling into replicative catastrophe. ([http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129678/?tool=pubmed Eigen 2002])
* Does it had the necesary genetic machinery to support DNA?
* Does it had the necesary genetic machinery to support DNA?

Revision as of 16:30, 10 November 2009

This project is about designing an organism that resembles the Last Universal Common Ancestor and whose construction is feasible.

Replication machinery

We have to start by:

  • Estimate the genomic size of LUCA.

Concivably an organism could survive in a controlled environment with a minimal genome of just 113kbp and 151 genes (Forster 2006). However, recent estimates sugest that LUCA was complex and probably had more than 600 genes (Kooning 2003).

  • Check if a RNA genome can sustain such genome size.

RNA is much more error-prone than DNA due to its higher mutation rate, so that RNA molecules cannot exceed certain size (Eigen limit) without falling into replicative catastrophe. (Eigen 2002)

  • Does it had the necesary genetic machinery to support DNA?

Atte (membrillo): Wweww Desde Xicotencatl Tlalpan, translate this Google :)

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