User:GMcArthurIV: Difference between revisions

From OpenWetWare
Jump to navigationJump to search
No edit summary
No edit summary
Line 18: Line 18:
<center>''All of the effects of Nature are only the mathematical consequences of a small number of immutable laws.''  –Pierre Simon de LaPlace</center>
<center>''All of the effects of Nature are only the mathematical consequences of a small number of immutable laws.''  –Pierre Simon de LaPlace</center>
<br />
<br />
My good friend Kevin Hershey and I will be working together to design and build a novel bioprocess that is based on engineered bacteria capable of cellulose metabolism for the production of biofuel.  Although this is a collaboration, I will focus my research on the development of the host bacteria using the engineering principles of synthetic biology while Kevin will be responsible for the bioreactor design.
Biofuel production.
==Interesting Literature==
==Interesting Literature==
===Biophotonics===
#[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=7832590&ordinalpos=119&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Photobiology of bacteria]
#[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=7832590&ordinalpos=119&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Photobiology of bacteria]
#[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17372221&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Proteorhodopsin photosystem gene expression enables photophosphorylation in a heterologous host] by DeLong ''et al''
#[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17372221&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Proteorhodopsin photosystem gene expression enables photophosphorylation in a heterologous host] by DeLong ''et al''
#[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16707677&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum  Complete cellulase system in the marine bacterium Saccharophagus degradans strain 2-40T] by by Weiner ''et al''
# [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17277079&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Light-powering E. coli with proteorhodopsin]
# [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17277079&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Light-powering E. coli with proteorhodopsin]
# [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16008504&ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumNew  Insights into metabolic properties of marine bacteria encoding proteorhodopsins]
# [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16008504&ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumNew  Insights into metabolic properties of marine bacteria encoding proteorhodopsins]
#Light-driven hydrogen production by a hybrid complex of a [NiFe]-hydrogenase and the cyanobacteria photosystem I
#Light-driven hydrogen production by a hybrid complex of a [NiFe]-hydrogenase and the cyanobacteria photosystem I
===Feedstock===
#[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16707677&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum  Complete cellulase system in the marine bacterium Saccharophagus degradans strain 2-40T] by by Weiner ''et al''
#Differential activation of E. coli chemoreceptors by blue-light stimuli
#Differential activation of E. coli chemoreceptors by blue-light stimuli
===Metabolic Engineering===
#[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17289987&ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Challenges in engineering microbes for biofuel production] by Stephanopoulos
#[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17289987&ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Challenges in engineering microbes for biofuel production] by Stephanopoulos
#[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16270654&ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Metabolic engineering] by Stephanopoulos
#[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16270654&ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Metabolic engineering] by Stephanopoulos
Line 40: Line 43:
==Contact==
==Contact==
[mailto:mcarthur@virginia.edu George's email]<br /><br />
[mailto:mcarthur@virginia.edu George's email]<br /><br />
<center>http://upload.wikimedia.org/wikipedia/en/thumb/7/7b/FPbeachTsien.jpg/600px-FPbeachTsien.jpg</center>
A San Diego beach scene drawn with an eight color palette of bacterial colonies expressing fluorescent proteins derived from GFP and the red-fluorescent coral protein dsRed. The colors include BFP, mTFP1, Emerald, Citrine, mOrange, mApple, mCherry and mGrape. Artwork by Nathan Shaner, photography by Paul Steinbach, created in the lab of Roger Tsien in 2006.
<center>http://www.marinebiotech.org/images/infinsp1.jpg</center>
<center>http://www.marinebiotech.org/images/infinsp1.jpg</center>

Revision as of 11:29, 5 July 2007

VGEM

http://www.che.virginia.edu/images/index_banner.gif
Everything that living things do can be understood in terms of the jigglings and wigglings of atoms. –Richard P. Feynman


George McArthur IV

George is the founder of UVA's Virginia Genetically Engineered Machine (VGEM) Team. He is a rising fourth-year chemical engineering and music double major concentrating in biotechnology and composition respectively.

Academic Interests

If there is magic on this planet, it is contained in water. –Loren Eisley


My research goals include utilizing synthetic biology principles, in particular standardized biological parts derived from marine organisms, in the genetic circuit and metabolic pathway engineering of microorganisms for use in large-scale industrial bioprocesses including the bioproduction of specialty chemicals, biofuels and biopharmaceuticals. I'm currently designing an undergraduate synthetic biology course at UVA titled Biological Systems Design.

My undergraduate studies at the University of Virginia in Chemical Engineering and Biotechnology (in addition to Music), coupled with future graduate studies in biological engineering, marine biotechnology and applied molecular microbiology will hopefully prepare me to tackle old and new bioengineering problems, including the bioremediation of our planet's coral reefs, and participate in the exciting biotech revolution that is occurring and that will continue to shape our world.

http://www.heartpunchstudio.com/images/wHPOceanCode.jpg


Undergraduate Thesis Project

All of the effects of Nature are only the mathematical consequences of a small number of immutable laws. –Pierre Simon de LaPlace


Biofuel production.

Interesting Literature

Biophotonics

  1. Photobiology of bacteria
  2. Proteorhodopsin photosystem gene expression enables photophosphorylation in a heterologous host by DeLong et al
  3. Light-powering E. coli with proteorhodopsin
  4. Insights into metabolic properties of marine bacteria encoding proteorhodopsins
  5. Light-driven hydrogen production by a hybrid complex of a [NiFe]-hydrogenase and the cyanobacteria photosystem I

Feedstock

  1. Complete cellulase system in the marine bacterium Saccharophagus degradans strain 2-40T by by Weiner et al
  2. Differential activation of E. coli chemoreceptors by blue-light stimuli

Metabolic Engineering

  1. Challenges in engineering microbes for biofuel production by Stephanopoulos
  2. Metabolic engineering by Stephanopoulos
  3. Global physiological understanding and metabolic engineering of microorganisms based on omics studies by Park et al

Links

Contact

George's email

http://www.marinebiotech.org/images/infinsp1.jpg
Retrieved from "https://openwetware.org/mediawiki/index.php?title=User:GMcArthurIV&oldid=127834"