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==[[IGEM:VGEM/2007| VGEM]]==
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<center>''Everything that living things do can be understood in terms of the jigglings and wigglings of atoms.'' –Richard P. Feynman</center>
<span style='font-size:16.0pt'>
George McArthur IV<br>
</span>
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<div style="padding: 10px; width: 914px; border: 5px solid #2B60DE;">
[[Image:George McArthur IV - Bayer Lab.JPG|thumb|225px|left|George McArthur, Whitaker International Fellow at Imperial College London]]
<center>
'''''Imagination is more important than knowledge.''''' <br />
'''''Knowledge is limited. Imagination encircles the world.''''' <br />
- Einstein <br />
</center>
<br />
<br />
==George McArthur IV==
George is the founder of UVA's Virginia Genetically Engineered Machine [[IGEM:VGEM/2007| (VGEM)]] Team.  He is a rising fourth-year chemical engineering and music double major concentrating in biotechnology and composition respectively.
==Academic Interests==
<center>''If there is magic on this planet, it is contained in water.''  –Loren Eisley<br /></center>
<br />
<br />
My research goals include utilizing [http://www.syntheticbiology.org synthetic biology] principles, in particular standardized biological parts derived from marine organisms, in the genetic circuit and metabolic pathway engineering of microorganisms for use in large-scale industrial bioprocesses including the bioproduction of specialty chemicals, biofuels and biopharmaceuticals. I'm currently designing an undergraduate synthetic biology course at UVA titled [[CHE.496/2008| ''Biological Systems Design.'']]<br />
My research is focused on the development of genetically encoded molecular machines to control the expression and activity of metabolic pathways in microbes. This is made possible largely by significant advances in computational, systems and synthetic biology.  I earned a BS in 2008 from the University of Virginia where I studied music, chemical engineering and biology and was mentored by Erik Fernandez (chemical engineering) and Jason Papin (biomedical engineering). I carried out my graduate research with [http://bayerlab.com/ Travis Bayer] (synthetic biology) at Imperial College London, where I was a Whitaker International Fellow, and with [http://www.systemsbiology.vcu.edu/ Steve Fong] at Virginia Commonwealth University (chemical engineering) where I earned my PhD in 2013. In addition to my research, I develop material for biology and biotechnology curricula. My research interests include:
<br />
<br />
My undergraduate studies at the [http://www.virginia.edu University of Virginia] in [http://www.che.virginia.edu Chemical Engineering and Biotechnology] (in addition to [http://www.virginia.edu/music Music]), coupled with future graduate studies in biological engineering, marine biotechnology and applied molecular microbiology will hopefully prepare me to tackle old and new bioengineering problems, including the bioremediation of our planet's coral reefs, and participate in the exciting biotech revolution that is occurring and that will continue to shape our world.
<br />
<br />
<center>http://www.heartpunchstudio.com/images/wHPOceanCode.jpg</center>
<br />
<br />
==Undergraduate Thesis Project==
*Orthogonal gene expression
<center>''All of the effects of Nature are only the mathematical consequences of a small number of immutable laws.''  –Pierre Simon de LaPlace</center>
*Artificial gene networks
*Synthetic metagenomics
*Genome organization, refactoring & design
*Metabolic, organellar & enzyme engineering
*Genome-scale, single-cell characterization
<br />
<br />
Biofuel production.
==Education & Training==
==Interesting Literature==
'''Imperial College London ·''' ''London, UK'' '''·''' 2011 — 2012
===Biophotonics===
*Whitaker International Fellow '''·''' Bioengineering
#[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=7832590&ordinalpos=119&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Photobiology of bacteria]
**Advised by Travis S. Bayer
#[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17372221&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Proteorhodopsin photosystem gene expression enables photophosphorylation in a heterologous host] by DeLong ''et al''
 
# [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17277079&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Light-powering E. coli with proteorhodopsin]
'''Virginia Commonwealth University ·''' ''Richmond, VA'' '''·''' 2008 — 2013
# [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16008504&ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumNew  Insights into metabolic properties of marine bacteria encoding proteorhodopsins]
*Ph.D. '''·''' Chemical and Biological Engineering
#Light-driven hydrogen production by a hybrid complex of a [NiFe]-hydrogenase and the cyanobacteria photosystem I
**Advised by Stephen S. Fong
===Feedstock===
*M.S. '''·''' Chemical Engineering
#[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16707677&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum  Complete cellulase system in the marine bacterium Saccharophagus degradans strain 2-40T] by by Weiner ''et al''
 
#Differential activation of E. coli chemoreceptors by blue-light stimuli
'''University of Virginia ·''' ''Charlottesville, VA'' '''·''' 2002 — 2008
===Metabolic Engineering===
*B.S. '''·''' Chemical Engineering, Music, Biology minor
#[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17289987&ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Challenges in engineering microbes for biofuel production] by Stephanopoulos
**Advised by Erik J. Fernandez and Jason A. Papin
#[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16270654&ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Metabolic engineering] by Stephanopoulos
 
#[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16041571&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus Global physiological understanding and metabolic engineering of microorganisms based on omics studies] by Park ''et al''
<br />
==Links==
==Publications==
*[http://www.gossamerfidelity.com Gossamer Fidelity (the band)]
*'''G.H. McArthur IV''', J.C. Anderson and S.S. Fong. (2013). Modulating bacterial gene expression with synthetic extended promoters. ''In preparation''.
*[http://www.sorcerer2expedition.org/version1/HTML/main.htm Sorcerer II Expedition]
*A.B. Fisher, Z.B. Canfield, L.C. Hayward, S.S. Fong and '''G.H. McArthur IV'''. (2013) [http://www.frontiersin.org/Journal/10.3389/fbioe.2013.00012/abstract ''ex vivo'' DNA assembly]. ''Front. Bioeng. Biotechnol.''
*[http://www.syntheticgenomics.com Synthetic Genomics (the company)]
*M. Montague, '''G.H. McArthur 4th''', C.S. Cockell, J. Held, W. Marshall, L.A. Sherman, N. Wang, W.L. Nicholoson, D. Tarjan and J. Cumbers. (2012). [http://online.liebertpub.com/doi/abs/10.1089/ast.2012.0829 The role of synthetic biology for in situ resource utilization (ISRU)]. ''Astrobiology''.
*[http://mmbl.uprm.edu Molecular Marine Biology Laboratory]
*'''G.H. McArthur 4th''' and S.S. Fong. (2010). [http://www.hindawi.com/journals/jbb/2010/459760.abs.html Toward engineering synthetic microbial metabolism]. ''J. Biomed. Biotechnol.'' doi:10.1155/2010/459760.
*[http://www.marinebiotech.org Marine Biotech]
<br />
*[http://ibe.org Institute of Biological Engineering]
==Presentations==
*[http://www.homestarrunner.com homestarrunner.com]
*Poster - Orthogonal and tunable expression of metabolic pathways, Synthetic Biology 6.0. Imperial College, London, UK, 9-11 July 2013
==Contact==
*Poster - Predictable gene expression using extended promoters and orthogonal cellular machinery, Cell Factories and Biosustainability. Favrholm, Copenhagen, DK, 5-8 May 2013
[mailto:mcarthur@virginia.edu George's email]<br /><br />
*Poster - The development of a genetically encoded, function-based taxol biosensor, Metabolic Engineering IX. Biarritz, FR, 3-7 June 2012
<center>http://www.marinebiotech.org/images/infinsp1.jpg</center>
*Poster - An orthogonal transcription platform for fine-tuning gene expression, Synthetic Biology 5.0. Stanford University, Stanford, CA, 15-17 June 2011
*Poster (invited) - A synthetic platform for controlling gene expression, Workshop: What are the potential roles of synthetic biology in NASA's mission?, 30-31 October 2010, NASA Ames Center, Moffett Field, CA
*Poster - Modulating gene expression in ''Escherichia coli'' with synthetic UP elements, BIOFAB 2010 Community Meeting, 19-20 July 2010, Emeryville, CA
*Poster - Modulating gene expression in ''Escherichia coli'' with synthetic UP elements, ASM 2010, 23-27 May 2010, San Diego, CA
*Poster - ''Chlamydomonas reinhardtii'' as a photosynthetic cellular chassis and power supply for synthetic biological systems, BioSysBio 2009, 23-25 March 2009, Cambridge University, Cambridge, UK
*Poster - ''Chlamydomonas reinhardtii'' as a platform for the direct photosynthesis of advanced biofuels, Institute of Biological Engineering 2009 annual meeting, 19-22 March 2009, Santa Clara, CA
*Poster - A bottom-up approach to synthetic biology education: From iGEM teams to undergraduate curricula, Synthetic Biology 4.0, 10-12 October 2008, HKUST, Hong Kong, China
*Talk - [http://tv.theiet.org/technology/electronics/1199.cfm The Virginia Genetically Engineered Machine Team], BioSysBio 2008, 20-22 April 2008, Imperial College, London, UK
*Poster - Harvesting cellulose and light to power butanol biosynthesis: A synthetic biology approach to metabolic engineering, Institute of Biological Engineering 2008 annual meeting, 6-9 March 2008, Chapel Hill, NC
*Talk/poster - Harvesting cellulose and light to power butanol biosynthesis: A synthetic biology approach to metabolic engineering, iGEM 2007, 3-4 November 2007, MIT, Cambridge, MA
<br />
==Development of Courses and Educational Programs==
I am the founder of the iGEM teams at the University of Virginia and Virginia Commonwealth University. In addition, I have developed undergraduate and graduate courses in synthetic biology.
<br />
===Courses===
*Spring 2008, University of Virginia - [[CHE.496/2008| ''Biological Systems Design'']]
*Fall 2009, Virginia Commonwealth University - [[VCU/Courses/Synthetic Biology Fundamentals| ''Synthetic Biology Fundamentals'']]
<br />
===iGEM Teams===
*[http://parts.mit.edu/igem07/index.php/Virginia University of Virginia 2007]
*[http://2008.igem.org/Team:Virginia University of Virginia 2008]
*[http://2009.igem.org/Team:Virginia_Commonwealth Virginia Commonwealth University 2009]
*[http://openwetware.org/wiki/Virginia_United/2010 Virginia United 2010]
*[http://2011.igem.org/Team:VCU Virginia Commonwealth University 2011]
 
<br />
===Press===
*[http://www.virginia.edu/uvatoday/newsRelease.php?id=4051 "Students Advance Synthetic Biology Research at U.Va. (Jan. 2008)]
*[http://www.virginia.edu/uvatoday/newsRelease.php?id=7770 "Ambitious Undergraduate Research Breaks New Ground" (Feb. 2009)]
*[http://www.washingtonpost.com/wp-dyn/content/article/2009/10/22/AR2009102204628.html "New works of science nonfiction: U-Va. students are using 'BioBricks' to try to build an original life form" (Oct. 2009)]
*[http://www.virginia.edu/uvatoday/newsRelease.php?id=10310 "U.Va. Team Strikes Gold in Genetically Engineered Machine Competition" (Nov. 2009)]
*[http://www.uvamagazine.org/features/article/reinventing_life/ "Reinventing Life: The Strange and Wondrous Science of Biological Technology" (UVa, Spring 2010)]
*[https://www.vbi.vt.edu/public_relations/press_releases/virginia_united_igem_team "Virginia United undergraduate iGEM team to compete in synthetic biology competition" (May 2010)]
*[http://www.vtnews.vt.edu/articles/2010/06/2010-445.html "Virginia Tech undergraduates join Virginia United iGEM team for national synthetic biology competition" (June 2010)]
*[http://www.news.vcu.edu/news/VCU_to_participate_in_a_fourschool_coalition_to_tackle_competitive "VCU to Participate in a Four-School Coalition to Tackle Competitive iGEM Competition" (July 2010)]
*[http://blogs.hsc.edu/biology/2010/11/03/vcu-synthetic-biology-team-leaders-visit-h-sc/ "VCU synthetic biology team leaders visit H-SC" (Nov. 2010)]
*[http://www.news.vcu.edu/news/VCU_to_participate_in_a_fourschool_coalition_to_tackle_competitive "Virginia Team Wins Bronze Medal in Genetically Engineered Machines Competition" (Dec. 2010)]

Revision as of 12:14, 11 November 2013

·

George McArthur IV

George McArthur, Whitaker International Fellow at Imperial College London

Imagination is more important than knowledge.
Knowledge is limited. Imagination encircles the world.
- Einstein



My research is focused on the development of genetically encoded molecular machines to control the expression and activity of metabolic pathways in microbes. This is made possible largely by significant advances in computational, systems and synthetic biology. I earned a BS in 2008 from the University of Virginia where I studied music, chemical engineering and biology and was mentored by Erik Fernandez (chemical engineering) and Jason Papin (biomedical engineering). I carried out my graduate research with Travis Bayer (synthetic biology) at Imperial College London, where I was a Whitaker International Fellow, and with Steve Fong at Virginia Commonwealth University (chemical engineering) where I earned my PhD in 2013. In addition to my research, I develop material for biology and biotechnology curricula. My research interests include:


  • Orthogonal gene expression
  • Artificial gene networks
  • Synthetic metagenomics
  • Genome organization, refactoring & design
  • Metabolic, organellar & enzyme engineering
  • Genome-scale, single-cell characterization


Education & Training

Imperial College London · London, UK · 2011 — 2012

  • Whitaker International Fellow · Bioengineering
    • Advised by Travis S. Bayer

Virginia Commonwealth University · Richmond, VA · 2008 — 2013

  • Ph.D. · Chemical and Biological Engineering
    • Advised by Stephen S. Fong
  • M.S. · Chemical Engineering

University of Virginia · Charlottesville, VA · 2002 — 2008

  • B.S. · Chemical Engineering, Music, Biology minor
    • Advised by Erik J. Fernandez and Jason A. Papin


Publications


Presentations

  • Poster - Orthogonal and tunable expression of metabolic pathways, Synthetic Biology 6.0. Imperial College, London, UK, 9-11 July 2013
  • Poster - Predictable gene expression using extended promoters and orthogonal cellular machinery, Cell Factories and Biosustainability. Favrholm, Copenhagen, DK, 5-8 May 2013
  • Poster - The development of a genetically encoded, function-based taxol biosensor, Metabolic Engineering IX. Biarritz, FR, 3-7 June 2012
  • Poster - An orthogonal transcription platform for fine-tuning gene expression, Synthetic Biology 5.0. Stanford University, Stanford, CA, 15-17 June 2011
  • Poster (invited) - A synthetic platform for controlling gene expression, Workshop: What are the potential roles of synthetic biology in NASA's mission?, 30-31 October 2010, NASA Ames Center, Moffett Field, CA
  • Poster - Modulating gene expression in Escherichia coli with synthetic UP elements, BIOFAB 2010 Community Meeting, 19-20 July 2010, Emeryville, CA
  • Poster - Modulating gene expression in Escherichia coli with synthetic UP elements, ASM 2010, 23-27 May 2010, San Diego, CA
  • Poster - Chlamydomonas reinhardtii as a photosynthetic cellular chassis and power supply for synthetic biological systems, BioSysBio 2009, 23-25 March 2009, Cambridge University, Cambridge, UK
  • Poster - Chlamydomonas reinhardtii as a platform for the direct photosynthesis of advanced biofuels, Institute of Biological Engineering 2009 annual meeting, 19-22 March 2009, Santa Clara, CA
  • Poster - A bottom-up approach to synthetic biology education: From iGEM teams to undergraduate curricula, Synthetic Biology 4.0, 10-12 October 2008, HKUST, Hong Kong, China
  • Talk - The Virginia Genetically Engineered Machine Team, BioSysBio 2008, 20-22 April 2008, Imperial College, London, UK
  • Poster - Harvesting cellulose and light to power butanol biosynthesis: A synthetic biology approach to metabolic engineering, Institute of Biological Engineering 2008 annual meeting, 6-9 March 2008, Chapel Hill, NC
  • Talk/poster - Harvesting cellulose and light to power butanol biosynthesis: A synthetic biology approach to metabolic engineering, iGEM 2007, 3-4 November 2007, MIT, Cambridge, MA


Development of Courses and Educational Programs

I am the founder of the iGEM teams at the University of Virginia and Virginia Commonwealth University. In addition, I have developed undergraduate and graduate courses in synthetic biology.

Courses


iGEM Teams


Press

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