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| ==[[IGEM:VGEM/2007| VGEM]]== | | {| class="wikitable" border="0" cellpadding="5" cellspacing="1" style="text-align:center" |
| <center>http://www.che.virginia.edu/images/index_banner.gif</center> | | !width=934px align="left" valign="top" style="background:#2B60DE; color:white"| |
| <center>''Everything that living things do can be understood in terms of the jigglings and wigglings of atoms.'' –Richard P. Feynman</center>
| | <span style='font-size:16.0pt'> |
| | George McArthur IV<br> |
| | </span> |
| | |- |
| | |} |
| | <div style="padding: 10px; width: 914px; border: 5px solid #2B60DE;"> |
| | [[Image:George McArthur IV - Bayer Lab.JPG|225px|left|]] |
| | <center> |
| | '''''Imagination is more important than knowledge.''''' <br /> |
| | '''''Knowledge is limited. Imagination encircles the world.''''' <br /> |
| | - Einstein <br /> |
| | </center> |
| <br /> | | <br /> |
| ==George McArthur IV==
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| George is the founder of UVA's Virginia Genetically Engineered Machine [[IGEM:VGEM/2007| (VGEM)]] Team. He is a rising fourth-year chemical engineering and music double major concentrating in biotechnology and composition respectively.
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| ==Academic Interests==
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| <center>''If there is magic on this planet, it is contained in water.'' –Loren Eisley<br /></center>
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| <br /> | | <br /> |
| My research goals include utilizing [http://www.syntheticbiology.org synthetic biology] principles, in particular standardized biological parts derived from marine organisms, in the genetic circuit and metabolic pathway engineering of microorganisms for use in large-scale industrial bioprocesses including the bioproduction of specialty chemicals, biofuels and biopharmaceuticals. I'm currently designing an undergraduate synthetic biology course at UVA titled [[CHE.496/2008| ''Biological Systems Design.'']]<br />
| | I am a Scientist at [http://arzeda.com Arzeda Corp.], where I develop novel metabolism in industrial bacteria and fungi. Please visit [http://mcarthurresearch.com my webpage] for more information about my current and past work in synthetic biology, metabolic engineering and related biotechnology. |
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| My undergraduate studies at the [http://www.virginia.edu University of Virginia] in [http://www.che.virginia.edu Chemical Engineering and Biotechnology] (in addition to [http://www.virginia.edu/music Music]), coupled with future graduate studies in biological engineering, marine biotechnology and applied molecular microbiology will hopefully prepare me to tackle old and new bioengineering problems, including the bioremediation of our planet's coral reefs, and participate in the exciting biotech revolution that is occurring and that will continue to shape our world.
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| <center>http://www.heartpunchstudio.com/images/wHPOceanCode.jpg</center>
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| <br /> | | <br /> |
| ==Undergraduate Thesis Project==
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| <center>''All of the effects of Nature are only the mathematical consequences of a small number of immutable laws.'' –Pierre Simon de LaPlace</center>
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| <br /> | | <br /> |
| My good friend Kevin Hershey and I will be working together to design and build a novel bioprocess that is based on engineered bacteria capable of cellulose metabolism for the production of biofuel. Although this is a collaboration, I will focus my research on the development of the host bacteria using the engineering principles of synthetic biology while Kevin will be responsible for the bioreactor design.
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| ==Interesting Literature==
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| #[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=7832590&ordinalpos=119&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Photobiology of bacteria]
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| #[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17372221&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Proteorhodopsin photosystem gene expression enables photophosphorylation in a heterologous host] by DeLong ''et al''
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| #[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16707677&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Complete cellulase system in the marine bacterium Saccharophagus degradans strain 2-40T] by by Weiner ''et al''
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| # [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17277079&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Light-powering E. coli with proteorhodopsin]
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| # [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16008504&ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumNew Insights into metabolic properties of marine bacteria encoding proteorhodopsins]
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| #Light-driven hydrogen production by a hybrid complex of a [NiFe]-hydrogenase and the cyanobacteria photosystem I
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| #Differential activation of E. coli chemoreceptors by blue-light stimuli
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| #[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17289987&ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Challenges in engineering microbes for biofuel production] by Stephanopoulos
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| #[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16270654&ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Metabolic engineering] by Stephanopoulos
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| #[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16041571&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus Global physiological understanding and metabolic engineering of microorganisms based on omics studies] by Park ''et al''
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| ==Links==
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| *[http://www.gossamerfidelity.com Gossamer Fidelity (the band)]
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| *[http://www.sorcerer2expedition.org/version1/HTML/main.htm Sorcerer II Expedition]
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| *[http://www.syntheticgenomics.com Synthetic Genomics (the company)]
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| *[http://mmbl.uprm.edu Molecular Marine Biology Laboratory]
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| *[http://www.marinebiotech.org Marine Biotech]
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| *[http://ibe.org Institute of Biological Engineering]
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| *[http://www.homestarrunner.com homestarrunner.com]
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| ==Contact==
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| [mailto:mcarthur@virginia.edu George's email]<br /><br />
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| <center>http://upload.wikimedia.org/wikipedia/en/thumb/7/7b/FPbeachTsien.jpg/600px-FPbeachTsien.jpg</center>
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| A San Diego beach scene drawn with an eight color palette of bacterial colonies expressing fluorescent proteins derived from GFP and the red-fluorescent coral protein dsRed. The colors include BFP, mTFP1, Emerald, Citrine, mOrange, mApple, mCherry and mGrape. Artwork by Nathan Shaner, photography by Paul Steinbach, created in the lab of Roger Tsien in 2006.
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| <center>http://www.marinebiotech.org/images/infinsp1.jpg</center>
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