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| ==[[IGEM:VGEM/2007| VGEM]]== | | {| class="wikitable" border="0" cellpadding="5" cellspacing="1" style="text-align:center" |
| <center>http://www.che.virginia.edu/images/index_banner.gif</center> | | !width=934px align="left" valign="top" style="background:#2B60DE; color:white"| |
| <center>''Everything that living things do can be understood in terms of the jigglings and wigglings of atoms.'' –Richard P. Feynman</center>
| | <span style='font-size:16.0pt'> |
| | George McArthur IV<br> |
| | </span> |
| | |- |
| | |} |
| | <div style="padding: 10px; width: 914px; border: 5px solid #2B60DE;"> |
| | [[Image:George McArthur IV - Bayer Lab.JPG|225px|left|]] |
| | <center> |
| | '''''Imagination is more important than knowledge.''''' <br /> |
| | '''''Knowledge is limited. Imagination encircles the world.''''' <br /> |
| | - Einstein <br /> |
| | </center> |
| <br /> | | <br /> |
| ==George McArthur IV==
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| George is the founder of UVA's Virginia Genetically Engineered Machine [[IGEM:VGEM/2007| (VGEM)]] Team. He is a rising fourth-year chemical engineering and music double major concentrating in biotechnology and composition respectively.
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| ==Academic Interests==
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| <center>''If there is magic on this planet, it is contained in water.'' –Loren Eisley<br /></center>
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| My research goals include utilizing [http://www.syntheticbiology.org synthetic biology] principles, in particular standardized biological parts derived from marine organisms, in the genetic circuit and metabolic pathway engineering of microorganisms for use in large-scale industrial bioprocesses including the bioproduction of specialty chemicals, biofuels and biopharmaceuticals. I'm currently designing an undergraduate synthetic biology course at UVA titled [[CHE.496/2008| ''Biological Systems Design.'']]<br />
| | I am a Scientist at [http://arzeda.com Arzeda Corp.], where I develop novel metabolism in industrial bacteria and fungi. Please visit [http://mcarthurresearch.com my webpage] for more information about my current and past work in synthetic biology, metabolic engineering and related biotechnology. |
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| My undergraduate studies at the [http://www.virginia.edu University of Virginia] in [http://www.che.virginia.edu Chemical Engineering and Biotechnology] (in addition to [http://www.virginia.edu/music Music]), coupled with future graduate studies in biological engineering, marine biotechnology and applied molecular microbiology will hopefully prepare me to tackle old and new bioengineering problems, including the bioremediation of our planet's coral reefs, and participate in the exciting biotech revolution that is occurring and that will continue to shape our world.
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| ==Undergraduate Thesis Project==
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| <center>''All of the effects of Nature are only the mathematical consequences of a small number of immutable laws.'' –Pierre Simon de LaPlace</center>
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| <br /> | | <br /> |
| My thesis project will consist of the two following parts: <br />
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| A cellulase-proteorhodopsin hybrid metabolic engine for butanol production by engineered ''Escherichia coli'': Metabolic pathway engineering via standardized biological parts. <br />
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| A cellulase-proteorhodopsin hybrid metabolic engine for butanol production by engineered ''Escherichia coli'': Bioreactor and process design for increased yield and volumetric productivity.
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| ==Interesting Literature==
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| ===Biophotonics===
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| #[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=7832590&ordinalpos=119&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Photobiology of bacteria]
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| #[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17372221&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Proteorhodopsin photosystem gene expression enables photophosphorylation in a heterologous host] by DeLong ''et al''
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| # [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17277079&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Light-powering E. coli with proteorhodopsin]
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| # [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16008504&ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumNew Insights into metabolic properties of marine bacteria encoding proteorhodopsins]
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| #Differential activation of E. coli chemoreceptors by blue-light stimuli
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| ===Cellulase===
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| #[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16707677&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Complete cellulase system in the marine bacterium ''Saccharophagus degradans'' strain 2-40T] by by Weiner ''et al''
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| #[http://aem.asm.org/cgi/content/abstract/68/1/53 Improvement of Cellulolytic Properties of Clostridium cellulolyticum by Metabolic Engineering]
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| ===Hydrogen Biofuel===
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| #Light-driven hydrogen production by a hybrid complex of a [NiFe]-hydrogenase and the cyanobacteria photosystem I
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| #[http://www.biohydrogen.nl/everyone Biohydrogen]
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| #[http://www.wired.com/science/discoveries/news/2006/02/70273 Mutant Algae Is Hydrogen Factory]
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| ===Butanol Biofuel===
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| #[http://www3.interscience.wiley.com/cgi-bin/abstract/109792702/ABSTRACT?CRETRY=1&SRETRY=0 Butanol fermentation research: upstream and downstream manipulations]
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| #[http://www3.interscience.wiley.com/cgi-bin/abstract/114109891/ABSTRACT Butanol production from agricultural residues: Impact of degradation products on ''Clostridium beijerinckii'' growth and butanol fermentation]
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| #[http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VRV-4NK4739-1&_user=709071&_coverDate=06%2F30%2F2007&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000039638&_version=1&_urlVersion=0&_userid=709071&md5=cd81c68d18f23cafdc69fa0d8a90c1b6 Bioproduction of butanol from biomass: from genes to bioreactors]
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| #[http://aem.asm.org/cgi/content/full/73/9/3061?view=long&pmid=17337545 Dynamics of Genomic-Library Enrichment and Identification of Solvent Tolerance Genes for Clostridium acetobutylicum]
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| #[http://pubs3.acs.org/acs/journals/doilookup?in_doi=10.1021/bp050360w Butanol Production from Corn Fiber Xylan Using ''Clostridium acetobutylicum'']
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| #[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16685494&ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Bacterial acetone and butanol production by industrial fermentation in the Soviet Union: use of hydrolyzed agricultural waste for biorefinery]
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| #[http://aem.asm.org/cgi/content/abstract/45/3/966 Butanol Production by a Butanol-Tolerant Strain of ''Clostridium acetobutylicum'' in Extruded Corn Broth]
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| ===Metabolic Engineering===
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| #[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17289987&ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Challenges in engineering microbes for biofuel production] by Stephanopoulos
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| #[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16270654&ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Metabolic engineering] by Stephanopoulos
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| #[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16041571&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus Global physiological understanding and metabolic engineering of microorganisms based on omics studies] by Park ''et al''
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| ==Links==
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| *[http://www.gossamerfidelity.com Gossamer Fidelity (the band)]
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| *[http://www.sorcerer2expedition.org/version1/HTML/main.htm Sorcerer II Expedition]
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| *[http://www.syntheticgenomics.com Synthetic Genomics (the company)]
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| *[http://mmbl.uprm.edu Molecular Marine Biology Laboratory]
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| *[http://www.marinebiotech.org Marine Biotech]
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| *[http://ibe.org Institute of Biological Engineering]
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| *[http://www.homestarrunner.com homestarrunner.com]
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| ==Contact==
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| [mailto:mcarthur@virginia.edu George's email]<br /><br />
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| <center>http://www.marinebiotech.org/images/infinsp1.jpg</center>
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