User:Gabriel Marceau

Contact Information

Snail mail

ITR Laboratories
Baie d'Urfé, Québec
Canada


e-mail
marceau DOT gabriel AT gmail DOT com

links
Academia.edu
BiomedExperts
LabRoots
LinkedIn
ORCID
Research Gate

Research Interests

General Interests

• Virology
  • Antigenic mimicry
  • Immune Evasion
  • Neurovirology
• Immunology
  • Neuroimmunology
• History (particularly science)

Techniques

• Histology
  • Cryostat ultra thin sections
  • Hematoxylin and eosin staining
  • Luxol fast blue staining
  • Immunohistochemistry labelling antibodies / DAB
• Molecular biology
  • Molecular cloning
  • Protein production in bacteria
  • Protein purification (antibodies)
• Immunology
  • Flow cytometry
  • ELISA
  • Proliferation assays
• Virology
  • Amplification
  • Plaque forming assay titration
  • Detection by polymerase chain reaction (PCR)
• Cell culture (primary and cell lines)
  • Mouse spleen cells
  • Liver infiltrating lymph nodes
  • Purification and culture of mouse T lymphocytes
    • Spleen
    • Lymph nodes
    • Liver
    • Central nervous system
• Animal experimentation
  • Mouse

Protocols

• Cell counting/hemacytometer
  • Hemacytometer

Education

Diplomas

• Ph.D. Virology and immunology, INRS - Institut Armand-Frappier, Laval, Canada, 2003-2010
• M.Sc. Microbiology and immunology, Université de Montréal, Montréal, Canada, 2001-2003
• B.Sc. Molecular biology and biotechnology, Université du Québec à Montréal, Montréal, Canada, 1997-2001

Scholarships

• Travel Award, NeuroInflammation Training Program (IRSC/FRSQ), 2008
• Travel Award, Fondation Armand-Frappier, 2007
• Travel Award, NeuroInflammation Training Program (IRSC/FRSQ), 2007
• Award, Multiple Sclerosis Society of Canada, 2007-2008
• Travel Award, NeuroInflammation Training Program (IRSC/FRSQ), 2006
• Award, Fondation Armand-Frappier / RBC Groupe Financier, 2005-2006
• Award, NeuroInflammation Training Program (IRSC/FRSQ), 2004-2006
• Award, Fondation Armand-Frappier / RBC Groupe Financier, 2004-2005
• Award, Fondation Armand-Frappier / RBC Groupe Financier, 2003-2004
• Award, Département microbiologie et immunologie, Université de Montréal, 2002

Publications

Papers

1. Marceau G, Yang R, Lapierre P, Béland K, and Alvarez F. Low-dose anti-CD3 antibody induces remission of active autoimmune hepatitis in xenoimmunized mice. Liver Int. 2015 Jan;35(1):275-84. DOI:10.1111/liv.12498 |

   (2014). Low-dose anti-CD3 antibody induces remission of active autoimmune hepatitis in xenoimmunized mice. Liver International. DOI:10.1111/liv.12498.

2. Ifergan I, Kebir H, Alvarez JI, Marceau G, Bernard M, Bourbonnière L, Poirier J, Duquette P, Talbot PJ, Arbour N, and Prat A. Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on α4 integrin. Brain. 2011 Dec;134(Pt 12):3560-77. DOI:10.1093/brain/awr268 |

   (2011). Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on α4 integrin. Brain, 134: 3557-74.

3. Jacomy H, St-Jean JR, Brison E, Marceau G, Desforges M, and Talbot PJ. Mutations in the spike glycoprotein of human coronavirus OC43 modulate disease in BALB/c mice from encephalitis to flaccid paralysis and demyelination. J Neurovirol. 2010 Jul;16(4):279-93. DOI:10.3109/13550284.2010.497806 |

   (2010). Mutations in the spike glycoprotein of human coronavirus OC43 modulate disease in BALB/c mice from encephalitis to flaccid paralysis and demyelination. Journal of Neurovirology, 16: 280-294.

4. Marceau G, Lapierre P, Béland K, Soudeyns H, and Alvarez F. LKM1 autoantibodies in chronic hepatitis C infection: a case of molecular mimicry?. Hepatology. 2005 Sep;42(3):675-82. DOI:10.1002/hep.20816 |

   (2005). LKM1 autoantibodies in chronic hepatitis C infection: a case of molecular mimicry? Hepatology, 42: 675-682.

5. Vitozzi S, Lapierre P, Djilali-Saiah I, Marceau G, Beland K, and Alvarez F. Anti-soluble liver antigen (SLA) antibodies in chronic HCV infection. Autoimmunity. 2004 May;37(3):217-22. DOI:10.1080/08916930410001686260 |

   (2004). Anti-Soluble Liver Antigen (SLA) Antibodies in Chronic HCV Infection. Autoimmunity, 37: 217-222.

6. Béland K, Lapierre P, Marceau G, and Alvarez F. Anti-LC1 autoantibodies in patients with chronic hepatitis C virus infection. J Autoimmun. 2004 Mar;22(2):159-66. DOI:10.1016/j.jaut.2003.11.001 |

   (2004). Anti-LC1 autoantibodies in patients with chronic hepatitis C virus infection. Journal of Autoimmunity, 22: 159-166.

Books/Sections

7. ISBN:9781588298676

Francine Lambert, Hélène Jacomy, Gabriel Marceau, Pierre J. Talbot. Chapter 8: Titration of human coronaviruses, HCoV-229E and HCoV-OC43, by an Indirect Immunoperoxidase Assay.

Master's thesis

• Gabriel Marceau. 2003. [Infection by hepatitis C virus and autoantibodies against cytochrome P450IID6: role of molecular mimicry]-French. Université de Montréal.

Doctoral thesis

• Gabriel Marceau. 2010. [Transient immunosuppression in a mouse model of multiple sclerosis]-French. INRS - Institut Armand-Frappier.

Meeting communications

Invited Lecturer

• Transient Immunosuppression Induced by a Neurovirulent Coronavirus in an Animal Model of Multiple Sclerosis. Internationales Graduiertenkolleg 1522. Institut für Virologie und Immunobiologie, Universität Würzburg. 19 avril 2011. Würzburg, Free State of Bavaria, Germany.

Talks

• Kathie Béland, Roland Yang, Boury Faye, Marie-France Gagnon, Gabriel Marceau, Pascal Lapierre, and Fernando Alvarez. Intranasal desensitisation as a new targeted treatment for type 2 autoimmune hepatitis in a murine model through the generation of regulatory cells populations. 9 au 13 novembre 2012. 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). Boston, MA, USA. Hepatology, 56: 86A (221), 2012.
• Gabriel Marceau, Pascal Lapierre, Kathie Béland, Roland Yang, and Fernando Alvarez, B Lymphocytes depletion therapy for autoimmune hepatitis. 24-27 february 2012. Canadian Digestive Diseases Week and Annual CASL Winter Meeting. Fairmont Queen Elizabeth, Montreal, Quebec, Canada.
• Kathie Béland, Roland Yang, Boury Faye, Marie-France Gagnon, Gabriel Marceau, Pascal Lapierre, Fernando Alvarez, Intranasal desensitisation as a new targeted treatment for type 2 autoimmune hepatitis in a murine model. 24-27 february 2012. Canadian Digestive Diseases Week and Annual CASL Winter Meeting. Fairmont Queen Elizabeth, Montreal, Quebec, Canada.
• Catherine Habel, Kathie Béland, Gabriel Marceau, Chantal Piché, C Marquet et Fernando Alvarez. [Induction of Immunological Tolerance by DNA Vaccination in a Mouse Model of Autoimmune Hepatitis]-french. June 8, 2011. XXVIe annual research meeting of graduate and postgraduate students. Research Center, Ste-Justine Hospital, Montreal, Canada.
• Igal Ifergan, Hania Kebir, Gabriel Marceau, Monique Bernard, Pierre Talbot, Nathalie Arbour and Alexandre Prat. VLA-4-Dependent Recruitment of Effector Memory CD8+ T Lymphocytes into the Central Nervous System. FOCIS2009 June 11-14, 2009. San Francisco, CA, USA. Clin Immunol, 131: S11 (S1), 2009.
• Gabriel Marceau and Pierre Talbot. Immunomodulation by a neurovirulent coronavirus. 57th Annual Meeting of the Canadian Society for Microbiologists June 17-20, 2007. Université Laval, Québec, Canada.
• Gabriel Marceau et Pierre Talbot. [Immunomodulation by a neurovirulent coronavirus]-French. May 18, 2006. Colloque – Dialogues entre le système nerveux central et le système immunitaire. 74ème Congrès de l’ACFAS: Le savoir trame de la modernité du 15 au 19 mai 2006. Université McGill, Montréal, Canada.
• Gabriel Marceau and Pierre Talbot. Immunomodulation by a neurovirulent murine coronavirus. Mai 12, 2006. 1st Annual Neuroinflammation Symposium. Douglas Hospital, Montréal, Canada.
• Gabriel Marceau, Pascal Lapierre, Hugo Soudeyns et Fernando Alvarez. [Infection by hepatitis C virus and autoantibodies against cytochrome P450IID6: role of molecular mimicry]-French. November 6-8, 2003. Congrès INRS-Institut Armand-Frappier 2003. Manoir du Lac Delage, Stoneham, Canada.
• Kathie Béland, Pascal Lapierre, Gabriel Marceau and Fernando Alvarez. Anti-LC1 autoantibodies in patients with chronic hepatitis C virus infection. October 2-5, 2003. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) 16th Annual meeting. Hotel Fairmont Queen Elisabeth, Montréal, Canada. JPGN, 37: 393 (A211), 2003.
• Gabriel Marceau, Pascal Lapierre, Hugo Soudeyns et Fernando Alvarez. [Infection by hepatitis C virus and autoantibodies against cytochrome P450IID6: role of molecular mimicry]-French. June 6, 2003. XVIIIème congrès annuel de la recherche des étudiants gradués et post-gradués. Centre de recherche de l’Hôpital Ste-Justine, Montréal, Canada.

Posters

• Gabriel Marceau, Lev Kolodziesky, Guillaume Diagne, Julie Temblay, Sybil Thébaud, Miglena Toneva, Kelly Scribner Doering, C Kostrub, and Andrew Nelson. Acute Injury Biomarkerts Following Low Dose Gentamicin Treatment of Rats. March 24-27, 2014. Society of Toxicology's 53rd Annual Meeting. Phoenix, Arizona, USA. The Toxicologist (Toxicological Sciences), 138: 72 (286), 2014.
• * Gabriel Marceau, Kathie Béland, Pascal Lapierre, et Fernando Alvarez. (Poter of distinction) B Lymphocytes Depletion Therapy in a Mouse Model of Autoimmune Hepatitis . November 9-13, 2012. 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). Boston, MA, USA. Hepatology, 56: 186A (1975), 2012.
• Sara Bourbonnais, Gabriel Marceau, Kathie Béland, et Fernando Alvarez . Study of the pregnancy-induced remission of autoimmune hepatitis, in a murine model . November 9-13, 2012. 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). Boston, MA, USA. Hepatology, 56: 171A (1719), 2012.
• * Sara Bourbonnais, Gabriel Marceau, Kathie Béland et Fernando Alvarez. (Poster of distinction). Impact of pregnancy in a murine model of autoimmune hepatitis. 24-27 february 2012. Canadian Digestive Diseases Week and Annual CASL Winter Meeting. Fairmont Queen Elizabeth, Montreal, Quebec, Canada.
• Gabriel Marceau, Hélène Jacomy, Marc Desforges, Claude Daniel and Pierre J. Talbot. Transient immunosuppression by a neurovirulent coronavirus in an animal model of multiple sclerosis. June 22-27, 2008. XIth International Nidovirus Symposium. St. Catherine’s College Oxford, UK.
• Gabriel Marceau and Pierre J. Talbot. Immunomodulation by a neurovirulent murine coronavirus. December 7-10 2007. EndMS.ca. Fairmont Banffsprings, Banff, Canada.
• Gabriel Marceau and Pierre Talbot. Immunomodulation by a neurovirulent murine coronavirus. May 11-12, 2007. 2nd Annual Neuroinflammation Symposium. Château Bromont, Bromont, Canada.
• Gabriel Marceau and Pierre Talbot. Immunomodulation by a neurovirulent murine coronavirus. June 9-12, 2006. Canadian Society for Immunology 2006 Annual Meeting. The Westin Nova Scotian Hotel, Halifax, Canada.
• Gabriel Marceau et Pierre J. Talbot. [Caracterisation of autoimmunity induced by the murine coronavirus in a model of demyelination of the central nervous system]-French. November 3-5, 2005. 4ème Congrès Armand-Frappier. Auberge du Lac-à-l’Eau-Claire, Canada.
• Pascal Lapierre, Gabriel Marceau, Hugo Soudeyns and Fernando Alvarez. Autoantibodies in Hepatitis C Chronic Infection: A Case of Molecular Mimicry? July 18-23, 2004. 12th International Congress of Immunology. Palais des Congrès, Montréal, Canada. Clin. Invest. Med., 27: 91A (M6.83), 2004.
• * Gabriel Marceau, Pascal Lapierre, Hugo Soudeyns and Fernando Alvarez. (Poster of distinction) Hepatitis C virus chronic infection with anti-cytochrome P450IID6 autoantibodies : implication of molecular mimicry. October 2-5, 2003. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) 16th Annual meeting. Hotel Fairmont Queen Elisabeth, Montréal, Canada. JPGN, 37: 380 (A160), 2003.
• Gabriel Marceau, Pascal Lapierre, Hugo Soudeyns et Fernando Alvarez. [Infection par le virus de l’hépatite C et autoanticorps dirigés contre le cytochrome P450IID6 : rôle du mimétisme moléculaire]-French. January 22, 2003. Congrès des stagiaires de recherche en santé de la Faculté de médecine, du CHUM et des Centres hospitaliers et instituts affiliés à l’Université de Montréal. Palais des Congrès, Montréal, Canada. Médecine Sciences, 19: S40 (A220), 2003.

* Poster of distinction

Other Interests

Student Affairs

Past (AGEIAF INRS - Institut Armand-Frappier)

• Student Representative, Documentation Services Committee
• Student Representative, Virology and Immunology Program Committee
• Student Representative, Biosecurity Committee

Scientific Associations

• American Society for Virology
• Association francophone pour le savoir (ACFAS)
• Canadian Society for Immunology
• International Society for Advancement of Cytometry

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