User:Harald Hentschke

Contact Info

Harald Hentschke (an artistic interpretation)

Harald Hentschke
Section of Experimental Anaesthesiology
Department of Anaesthesiology
University Hospital of Tuebingen
Waldhörnlestr. 22
D-72072 Tübingen
Tel. ++49-7071/29 8 11 53
Fax ++49-7071/29 2 50 73
email: harald DOT hentschke AT uni MINUS tuebingen DOT de

Education

• 1989 - 1996, study of Biology, Universities of Bayreuth and Tübingen (Germany)
• 1995 – 1996, Diploma project, Center for Nonlinear Dynamics in Physiology and Medicine, McGill University, Montréal, Canada
• 1996, Diploma (Biology), University of Tübingen
• 1996 – 1999, PhD project with B. Antkowiak, Max-Planck-Institute for Biological Cybernetics, Tübingen
• 1997 - 1998, Graduiertenkolleg Neurobiologie, Tübingen
• 2000, PhD (Animal Physiology), University of Tübingen
• 2000 - 2003, Postdoc with C. Schwarz, Hertie Institute for Clinical Brain Research, University of Tübingen
• 2003 - 2005, Postdoc with R. A. Pearce, Department of Anesthesiology, University of Wisconsin, Madison
• 2005 - present, Research Scientist, Section of Experimental Anaesthesiology, University Hospital of Tübingen

Research interests

My principal research interest lies in the modulation of cortical and hippocampal networks by classical neuromodulators (acetylcholine) and substances interfering with GABAergic inhibition. Current projects are

• Cholinergic modulation of GABAergic inhibition in neocortex
• Enhancing spillover of GABA to peri- und extrasynaptic GABA(A) receptors – a possible route to anesthesia?

A methodological focus is the development of software tools (mostly written in Matlab) for data analysis and experimental control in the neurosciences. The aim is to produce customized and efficient/automated tools. Projects past and present include

• 'Measures of effect size toolbox' (with Maik Stüttgen, University of Bochum), available at the Matlab Central File Exchange and SourceForge
• time- and frequency domain analysis of multielectrode field potential recordings
• graphical user interface programs for event detection (e.g. spikes, postsynaptic currents) and IPSC fitting
• event-triggered stimulation/feedback control of behavioral setup for awake behaving rodents

Professional memberships

• Society for Neuroscience
• Associate Faculty Member, Faculty of 1000 medicine

Publications

• Hentschke H, Stüttgen MC. Computation of measures of effect size for neuroscience data sets. Eur J Neurosci 34:1887-1894, 2011 PubMed

• Drexler B, Hentschke H, Antkowiak B, Grasshoff C: Organotypic cultures as tools for testing neuroactive drugs - link between in-vitro and in-vivo experiments. Current Medicinal Chemistry, 17(36): 4538-4550 PubMed

• Schwarz C, Hentschke H, Butovas S, Haiss F, Stüttgen MC, Gerdjikov TV, Bergner CG, Waiblinger C: The head-fixed behaving rat - procedures and pitfalls. Somatosens Mot Res. 2010;27(4):131-48. Epub 2010 Oct 18. PubMed

• Kreuzer M, Hentschke H, Antkowiak B, Schwarz C, Kochs EF, Schneider G: Cross-Approximate Entropy of cortical local field potentials quantifies effects of anesthesia - a pilot study in rats. BMC Neurosci 11(1):122, 2010 PubMed

• Drexler B, Zinser S, Hentschke H, Antkowiak B: Diazepam Decreases Action Potential Firing of Neocortical Neurons via Two Distinct Mechanisms. Anesthesia & Analgesia 111:1394-1399; 2010 PubMed

• Hentschke H, Benkwitz C, Banks MI, Perkins MG, Homanics GE, Pearce RA: Altered GABAA,slow inhibition and network oscillations in mice lacking the GABAA receptor beta3 subunit. J Neurophysiol. 2009 Dec;102(6):3643-55. Epub 2009 Oct 21 PubMed

• Grasshoff C, Netzhammer N, Schweizer J, Antkowiak B, Hentschke H: Depression of spinal network activity by thiopental: Shift from phasic to tonic GABA(A) receptor-mediated inhibition. Neuropharmacology 2008 Oct 55(5): 793-802 PubMed

• Hentschke H, Perkins MG, Pearce RA, Banks MI: Muscarinic blockade weakens interaction of gamma with theta rhythms in mouse hippocampus. European Journal of Neuroscience. 2007 Sep 26(6): 1642-56 PubMed

• Perouansky M, Hentschke H, Perkins M, Pearce RA: Amnesic concentrations of the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6, 2N) and isoflurane alter hippocampal theta oscillations in vivo. Anesthesiology. 2007 Jun;106(6):1168-76 PubMed

• Grasshoff C, Drexler B, Hentschke H, Thiermann H, Antkowiak B: Cholinergic modulation of sevoflurane potency in cortical and spinal networks in vitro. Anesthesiology. 2007 Jun;106(6):1147-55 PubMed

• Hentschke H, Haiss F, Schwarz C: Central signals rapidly switch tactile processing in rat barrel cortex during whisker movements. Cerebral Cortex, 2006 Aug;16(8):1142-56 PubMed

• Hentschke H, Schwarz C, Antkowiak B: Neocortex is the major target of sedative concentrations of volatile anesthetics: strong depression of firing rates and increase of GABAA receptor-mediated inhibition. European Journal of Neuroscience. 2005 Jan;21(1):93-102 PubMed

• Antkowiak B, Hentschke H: Effects of benzodiazepines and general anaesthetics on the GABA(A) receptor: Where are the differences? Anästhesiologie Intensivmedizin Notfallmedizin Schmerztherapie 2000; 35: 593-5 PubMed

• Hentschke H, Antkowiak B: NMDA receptor-mediated changes of spontaneous activity patterns in thalamocortical slice cultures. Brain Research 1999; 830: 123-37 PubMed

• Antkowiak B, Hentschke H: Cellular mechanisms of gamma rhythms in rat neocortical brain slices probed by the volatile anaesthetic isoflurane. Neuroscience Letters 1997; 231: 87-90 PubMed

• Antkowiak B, Hentschke H, Kirschfeld K: Effects of volatile anaesthetics on spontaneous action potential firing of cerebellar Purkinje cells in vitro do not follow the Meyer-Overton rule. British Journal of Anaesthesia 1997; 79: 617-24 PubMed

Links

• Matlab File Exchange