User:Helen C. Lai

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== Publications ==
== Publications ==
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*Lai H.C., Johnson J.E. Neurogenesis or neuronal specification: Phosphorylation strikes again! 2008. Neuron. 58(1):3-5. (Preview) PMID 18400155
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#Lai pmid=18400155
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*Panteleeva I., Boutillier S., See V., Spiller D.G., Rouaux C., Almouzni G., Bailly D., Maison C., Lai H.C., Loeffler J.P., Boutillier A.L.  HP1alpha guides neuronal fate by timing E2F-targeted genes silencing during terminal differentiation. 2007. EMBO J. 26(15): 3616-28. PMID 17627279
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#Panteleeva pmid=17627279
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#Grabe-Lai pmid=17187053
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*Grabe M.*, Lai H.C.*, Jain M., Jan Y.N., Jan L.Y.  Structure prediction for the down state of a potassium channel voltage sensor. 2007. Nature. 445(7127): 550-553. * Equal contribution. PMID 17187053
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#Lai pmid=16791144
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#Lai pmid=16055063
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*Lai H.C., Jan L.Y.  The distribution and targeting of neuronal voltage-gated ion channels.  2006.  Nature Reviews Neuroscience. 7(7): 548-562. PMID 16791144
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#Serber pmid=12446779
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#Ou pmid=11775743
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*Lai H.C., Grabe M., Jan Y.N., Jan L.Y.  The S4 voltage sensor packs against the pore domain in the KAT1 voltage-gated potassium channel.  2005.  Neuron.  47(3):395-406. PMID 16055063
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*Serber Z., Lai H.C., Yang A., Ou H.D., Sigal M.S., Kelly A.E., Darimont B.D., Duijf P.H., Van Bokhoven H., McKeon F., Dötsch V.  A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism. 2002.  Mol. Cell Biol.  22(24):8601-11. PMID 12446779
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*Ou H.D., Lai H.C., Serber Z., Dötsch V.  Efficient identification of amino acid types for fast protein backbone assignments. 2001.  J. Biomol. NMR.  21(3):269-73. PMID 11775743
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== Contact info ==
== Contact info ==

Revision as of 17:31, 9 February 2009

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What lies beyond?
What lies beyond?

Contents

Biography

  • UC San Francisco, Ph.D. in the Laboratory of Dr. Lily Jan
  • Postdoc in the Johnson Lab

Research Interests

Ion Channels
For my graduate work, I determined structural constraints for the hyperpolarized state of the six-transmembrane voltage-gated potassium (Kv) channel, KAT1, from Arabidopsis thaliana. I conducted a conditional lethal/second-site suppressor screen that identified mutations in close proximity as determined by the rescue of functional channels in a yeast growth assay. A structural model of Kv channel packing emerged from these constraints that withstands experimental verification. This model together with existing data lends mechanistic insight into the structure and mechanism of voltage-gated ion channels.

Developmental Neuroscience
I am currently trying to determine the transcriptional regulatory code and downstream targets of Atoh1, a basic helix-loop-helix (bHLH) transcription factor involved in differentiation and cell type specification of neurons in the spinal cord and cerebellum.


Publications

  1. Lai HC, Grabe M, Jan YN, and Jan LY. . pmid:16055063. PubMed HubMed [Lai]
  2. Lai HC and Jan LY. . pmid:16791144. PubMed HubMed [Lai]
  3. Lai HC and Johnson JE. . pmid:18400155. PubMed HubMed [Lai]
  4. Panteleeva I, Boutillier S, See V, Spiller DG, Rouaux C, Almouzni G, Bailly D, Maison C, Lai HC, Loeffler JP, and Boutillier AL. . pmid:17627279. PubMed HubMed [Panteleeva]
  5. Grabe M, Lai HC, Jain M, Jan YN, and Jan LY. . pmid:17187053. PubMed HubMed [Grabe-Lai]
  6. Serber Z, Lai HC, Yang A, Ou HD, Sigal MS, Kelly AE, Darimont BD, Duijf PH, Van Bokhoven H, McKeon F, and Dötsch V. . pmid:12446779. PubMed HubMed [Serber]
  7. Ou HD, Lai HC, Serber Z, and Dötsch V. . pmid:11775743. PubMed HubMed [Ou]
All Medline abstracts: PubMed HubMed

Contact info

Helen C. Lai
Department of Neuroscience
UT Southwestern Medical Center
5323 Harry Hines Blvd., NA 4-146
Dallas, TX 75390-9111

Helen.Lai@utsouthwestern.edu

Lab 214-648-1874
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