User:Helen C. Lai

Biography

[[Image:|thumb|right|350px|Frame|]] In progress

Research Interests

 Ion Channels

Developmental Neuroscience To be updated...

Publications

7. Lai H.C., Johnson J.E. Neurogenesis or neuronal specification: Phosphorylation strikes again! 2008. Neuron. 58(1):3-5. (Preview)

6. Panteleeva I., Boutillier S., See V., Spiller D.G., Rouaux C., Almouzni G., Bailly D., Maison C., Lai H.C., Loeffler J.P., Boutillier A.L. HP1alpha guides neuronal fate by timing E2F-targeted genes silencing during terminal differentiation. 2007. EMBO J. 26(15): 3616-28.

5. Grabe M.*, Lai H.C.*, Jain M., Jan Y.N., Jan L.Y. Structure prediction for the down state of a potassium channel voltage sensor. 2007. Nature. 445(7127): 550-553. * Equal contribution.

4. Lai H.C., Jan L.Y. The distribution and targeting of neuronal voltage-gated ion channels. 2006. Nature Reviews Neuroscience. 7(7): 548-562.

3. Lai H.C., Grabe M., Jan Y.N., Jan L.Y. The S4 voltage sensor packs against the pore domain in the KAT1 voltage-gated potassium channel. 2005. Neuron. 47(3):395-406.

2. Serber Z., Lai H.C., Yang A., Ou H.D., Sigal M.S., Kelly A.E., Darimont B.D., Duijf P.H., Van Bokhoven H., McKeon F., Dötsch V. A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism. 2002. Mol. Cell Biol. 22(24):8601-11.

1. Ou H.D., Lai H.C., Serber Z., Dötsch V. Efficient identification of amino acid types for fast protein backbone assignments. 2001. J. Biomol. NMR. 21(3):269-73.

Contact info

Helen C. Lai
Department of Neuroscience
UT Southwestern Medical Center
5323 Harry Hines Blvd., NA 4-146
Dallas, TX 75390-9111

Lab 214-648-1874