User:Ilya/Yeast/Mating pheromone response pathway

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  • Crosstalk in the pathways is eliminated by formation of pathway-specific complexes (Ste5:Ste11:Ste7:Fus3, Pbs2:Ste11:Hog1)
  • In S. cerevisiae, meiosis is initiated only by diploid cells deprived of glucose and nitrogen and grown in the presence of a nonfermentable carbon source [1]

Pheromone processing genes

  • STE14
    • carries out C-terminal methylation of prenylated proteins including a-factor, Ras1p, and Ras2p
    • encodes the prenylcysteine-dependent carboxyl methyltransferase that mediates methylation, the final step in modification of CAAX proteins; Ste14p is also membrane associated [2]
  • STE13
    • Dipeptidyl aminopeptidase A involved in maturation of a-factor
  • AXL1
    • Protease involved in proteolytic step of a-factor N-terminal processing
  • STE23
  • RAM1, RAM2
    • Required for a-factor prenylation
  • STE24
  • RCE1
  • KEX2
  • KEX1
  • STE23

Other genes

These genes are part of the mating machinery in yeast but not necessary part of the mating pheromone response pathway.

  • Swe1 - protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity
  • Ras1 - pombe homolog interacts with MAPKKK
  • SAG1 (α-agglutinin) - provides tight cell-cell adhesion during mating in S. cerevisiae.
  • FUS1 - protein with SH3 domain required for cell fusion during mating, located at the tip of the mating projection
  • BNI1/YNL271C (Saccharomyces cerevisiae)
    • Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1


  • Pathway architecture overview
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All Medline abstracts: PubMed HubMed
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