- Areas of species comparison:
- cell type control
- mating (connection to nutritional control)
- pheromone production
Pathogenic Fungi: Structural Biology and Taxonomy
Chapter 6: Regulation of Morphogenesis by Conserved Developmental Pathways in Pathogenic Fungi
The highly conserved pheromone response MAP kinase and nutrient-sensing cAMP/PKA signal pathways are critical for filamentation, mating and virulence in many pathogenic fungi. A comparison of their functions in two human pathogens Candida albicans and Cryptococcus neoformans, and in two plant pathogens, Magnaporthe grisea and Ustilago maydis, shows that virulence is tightly associated with filamentation and mating in these fungi, suggesting an evolutionary link between pathogenesis and cellular development.