User:Jacqueline Soegaard: Difference between revisions

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==Contact Info==
==Contact Info==
[[Image:OWWEmblem.png|thumb|right|Jacqueline Soegaard (an artistic interpretation)]]
[[Image:OWWEmblem.png|thumb|right|Jacqueline Soegaard (an artistic interpretation)]]
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<!-- Feel free to add brief descriptions to your research interests as well -->
<!-- Feel free to add brief descriptions to your research interests as well -->


[[Microalgae lipid fuel production]]  
[[Microalgae lipid fuel production]]
 
=== Background: ===
 
The use of photosynthetic microorganisms as sources of renewable energy has recently been the subject of much research and debate.  Notably, microalgae lipid production has been considered as a potential source of biofuels that would not compete with food products. Other advantages include the atmospheric capture CO2 by algae, which might help neutralize the effects of later hydrocarbon combustion. Algae biofuel is also non-toxic and biodegradable and renewable.
 
Nonetheless, there are many limitations to producing and extracting oil from algae, such as optimizing algae growth in bioreactors; lipid production and characteristics; extraction efficiency; and economic sustainability. We would like to improve the efficiency of algae energy production. Specifically, we will focus on the up-regulation of lipid biosynthesis, leading to increased fuel yield. High yields might help dispel initial cost worries. By using available genome sequence information from a variety of algae, as discoveries from other microorganism systems, we could select a point in the micro-algae lipid synthesis pathway to modify.  Some options would be to increase expression of anabolic enzymes, or decrease inhibitory regulation mechanisms.  Another possibility could be to add transform algae strains so as to extend the biosynthetic pathway of lipids in such a way that the biomass produced contains lipids that are closer to those that are used for combustion.
 
===Sources:===
 
*[http://ec.asm.org.libproxy.mit.edu/cgi/content/abstract/9/4/486 Genetic Engineering of Algae for Enhanced Biofuel Production]
Radakovits R, Jinkerson RE, Darzins A, Posewitz1 MC. ''Eukar Cell'' 2010 (9,4):486–501. 
 
This review collects the current research regarding algae biofuels and summarizes the challenges that need to be addressed in order to make algae a viable source of biofuels.  Some of the approaches proposed in this paper include: upgrading the direct biosynthesis of lipids, altering lipid characteristics so as to make them a more relevant fuel source, optimizing the conversion of carbohydrates to lipids, and improving photosynthetic efficiency.  From this paper, which was just published this month, we gathered that there is great interest in developing algae biofuels as an energy source.  As a consequence of this, there is ample opportunity for innovation and genetic optimization.  This paper also contains numerous references that can serve as starting points for research ideas and tools. 
 
*Some interesting presentations:
 
[http://www.slideboom.com/presentations/159830/Engineering-Challenges-in-Algae-Energy Engineering Challenges in Algae Energy]
 
*Useful webpages:
 
[http://algae.ucsd.edu/news-and-resources.shtml UCSD Center for Algae Techology]
 
*Potentially useful articles:
-Lu X, Vora H, Chaitan K.  Overproduction of free fatty acids in E. coli: Implications for biodiesel production.  Metab Eng 2008 (10;6): 333-339.
-Hu, Q., M. Sommerfeld, E. Jarvis, M. Ghirardi, M. Posewitz, M. Seibert, and A. Darzins. 2008. Microalgal triacylglycerols as feedstocks for biofuel production: perspectives and advances. Plant J. 54:621–639.


==Publications==
==Publications==
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==Registration/Questionnaire: 20.109 Spring 2010==
==Registration/Questionnaire: 20.109 Spring 2010==


===Last Name===
===Last Name: ===  
Soegaard
Soegaard
===First Name===
===First Name: ===
Jacqueline  
Jacqueline  


===Preferred name (if not first)===
[Course/Minor]
Major: Course 20 (Biological Engineering)
Potential Minors: Management Science in Course 15, French
Concentration: French


===Course/Minor===
===Year of Graduation:===
Major: Course 20 (Biological Engineering); Potential Minor: Management Science in Course 15, French
===Year of Graduation===
2012
2012
===Telephone #===
===Telephone #:===  
787.548.7440
787.548.7440
===Email===
===Email: ===  
jmsoe@mit.edu
jmsoe@mit.edu
===Potentially Relevant Background===
===Potentially Relevant Background===


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===Please briefly describe any previous laboratory experience===
===Please briefly describe any previous laboratory experience===
I worked at the Broad Institute during a summer genomics course as part of the MIT MITES program.  Last semester I UROPed at the Khademhosseini Lab, where I worked on a project which aimed at designing a chip device for detecting cardiotoxicity using a miniaturized ELISA and in-chip cell cultures.   
I worked at the Broad Institute during a summer genomics course as part of the MIT MITES program.  Last semester I UROPed at the Khademhosseini Lab, where I worked on a project which aimed at designing a chip device for detecting cardiotoxicity using a miniaturized ELISA and in-chip cell cultures.   


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Jing Jing Gong
Jing Jing Gong
<math> σ = F/A = (m*g)/A = (24.797 g * 9.8 m/s^2)/(4.84 cm^2) = 50.21 N/cm^2 </math>

Latest revision as of 13:05, 6 May 2010

Contact Info

Jacqueline Soegaard (an artistic interpretation)

I work in the 20.109 Lab at MIT. I learned about OpenWetWare from Natalie Kuldell, and I've joined because Student in BE 20.109.

Education

  • MIT Class of 2012, Course 20: Biological Engineering

Research interests

Microalgae lipid fuel production

Publications

Useful links


Please copy the source code from this page to your user page, fill in the answers and print out a copy for next time.
You do not need to keep the information on your user page once you've printed it out.

Registration/Questionnaire: 20.109 Spring 2010

Last Name:

Soegaard

First Name:

Jacqueline

[Course/Minor] Major: Course 20 (Biological Engineering) Potential Minors: Management Science in Course 15, French Concentration: French

Year of Graduation:

2012

Telephone #:

787.548.7440

Email:

jmsoe@mit.edu

Potentially Relevant Background

Have you taken/are you taking... Answer yes/no/when
7.05/5.07 (Biochemistry) No
7.06 (Cell Biology) No
7.03 (Genetics) Yes; Spring 2010
7.02 (General Biology Lab) No
5.310 (General Chemistry Lab) No


Do you have experience with... Answer yes/no/type
Cell culture (microbial/mammalian/yeast?) Yes, mammalian.
Molecular biology (electrophoresis, PCR, etc) Yes, PCR, electrophoresis, ELISA.

Please briefly describe any previous laboratory experience

I worked at the Broad Institute during a summer genomics course as part of the MIT MITES program. Last semester I UROPed at the Khademhosseini Lab, where I worked on a project which aimed at designing a chip device for detecting cardiotoxicity using a miniaturized ELISA and in-chip cell cultures.

Anything else you would like us to know?

I have NEVER seen such a gorgeous lab before!

Commitment to academic integrity

After you print out this page, please sign your name next to the following statement to indicate your agreement:

I have read and understood the 20.109 statement on collaboration and integrity.


Jing Jing Gong

[math]\displaystyle{ σ = F/A = (m*g)/A = (24.797 g * 9.8 m/s^2)/(4.84 cm^2) = 50.21 N/cm^2 }[/math]

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