User:James Chappell: Difference between revisions
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My personal research interest has been the understanding of biological mechanisms within the context of reduced systems, namely in vitro transcription and translation systems. My interest is in learning about other contexts in which reduced systems might find applications. Currently, we are investigating how to utilize such systems to gain insight into RNA function, in particular RNA network motifs. | My personal research interest has been the understanding of biological gene regulation mechanisms within the context of reduced systems, namely in vitro transcription and translation systems. My interest is in learning about other contexts in which reduced systems might find applications. Currently, we are investigating how to utilize such systems to gain insight into RNA function, in particular RNA network motifs. | ||
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===Education=== | ===Education and Career=== | ||
*Post Doc with Prof. Julius Lucks at Chemical and Biomedical Engineering, Cornell University | |||
PhD with Prof. Paul Freemont at Center for Synthetic Biology and Innovation, Imperial College London <br> | *PhD with Prof. Paul Freemont at Center for Synthetic Biology and Innovation, Imperial College London <br> | ||
*1st Class Honours Bsc in Biochemistry, Imperial College London <br> | |||
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<biblio> | <biblio> | ||
# 1 Chappell, J., Jensen, K., and Freemont, P.S. (2013). Validation of an entirely in vitro approach for rapid prototyping of DNA regulatory elements for synthetic biology. Nucleic Acids Res. [http://www.ncbi.nlm.nih.gov/pubmed/23371936 Pubmed] | # 1 Melissa K Takahashi, James Chappell, Clarmyra A Hayes, Zachary Z Sun, Jongmin Kim, Vipul Singhal, Kevin J Spring, Shaima Al-Khabouri, Christopher P Fall, Vincent Noireaux, Richard M. Murray, and Julius B. Lucks."Rapidly characterizing the fast dynamics of RNA genetic circuitry with cell-free transcription-translation (TX-TL) systems. " ACS Synthetic Biology, 2014. DOI: 10.1021/sb400206c | ||
# 2 Chappell,J., Takashashi, M. K., Meyer,S., Loughrey, D., Watters, K., Lucks,J. B. ''The Centrality of RNA for Engineering Gene Expression.'' Biotechnology Journal, 2013. DOI: 10.1002/biot.201300018 (FREE) | |||
# 3 Chappell, J., Jensen, K., and Freemont, P.S. (2013). Validation of an entirely in vitro approach for rapid prototyping of DNA regulatory elements for synthetic biology. Nucleic Acids Res. [http://www.ncbi.nlm.nih.gov/pubmed/23371936 Pubmed] | |||
# | # 4 Chappell, J. Freemont, P.S. SYNTHETIC BIOLOGY—A NEW GENERATION OF BIOFILM BIOSENSORS. [http://www.ncbi.nlm.nih.gov/books/NBK84447/ Pubmed Books] | ||
# | # 5 Gulati1, S. Rouilly, V. Niu1, X. Chappell, J. Kitney, R. Edel, J. Freemont, P. A, deMello.Opportunities for microfluidic technologies in synthetic biology. [http://www.ncbi.nlm.nih.gov/pubmed/19474079 Pubmed] | ||
</biblio> | </biblio> | ||
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===Contact Details=== | ===Contact Details=== | ||
Revision as of 13:17, 18 March 2014
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James Chappell
Research Interests
My personal research interest has been the understanding of biological gene regulation mechanisms within the context of reduced systems, namely in vitro transcription and translation systems. My interest is in learning about other contexts in which reduced systems might find applications. Currently, we are investigating how to utilize such systems to gain insight into RNA function, in particular RNA network motifs. |
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Education and Career
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Scientific Publications
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Contact DetailsJames Chappell, |