User:Jarle Pahr/Antibiotics

Notes and links regarding antibiotics:

http://gotsomescienceonyou.com/2013/08/06/resist-the-resistance/

http://openwetware.org/wiki/Fong:Antibiotics

http://bitesizebio.com/articles/antibiotic-stability-keep-your-gunpowder-dry/

http://openwetware.org/wiki/Endy:Preparing_Antibiotic_Stocks

ATCC Antibiotic concentration recommendations:

http://hymanlab.mpi-cbg.de/hyman_lab/wp-content/uploads/2012/08/atcc_recommendations_antibiotic_concentrations.pdf

Mupirocin: http://en.wikipedia.org/wiki/Mupirocin

Ampicillin:

Degraded by B-lactamase (encoded by bla)

http://openwetware.org/wiki/Ampicillin

Carbenicillin:

• Also degraded by B-lactamase, but slower than Ampicillin. (http://bitesizebio.com/articles/whats-the-problem-with-ampicillin-selection/)
• More expensive than ampicillin.

Kanamycin:

Capsule Formation is Necessary for Kanamycin Tolerance in Escherichia coli K12: http://www.microbiology.ubc.ca/sites/default/files/roles/drupal_ungrad/JEMI/17/05.1G.pdf

Chloramphenicol:

• Inhibits protein translation by interfering with peptide bond formation.

Bibliography:

Designing Antibiotic Cycling Strategies by Determining and Understanding Local Adaptive Landscapes : http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0056040

http://mbioblog.asm.org/mbiosphere/2013/05/resistance-to-last-line-antibiotic-also-makes-bacteria-resistant-to-immune-attacks.html

Persistence in the face of antibiotics:

http://www.sciencemag.org/content/334/6058/982

Lantibiotics:

http://www.ncbi.nlm.nih.gov/pubmed/19393544

Concepts

MIC

PAE

Bibliography

http://jac.oxfordjournals.org/content/54/1/139.full.pdf

The unstructured domain of colicin N kills Escherichia coli: http://onlinelibrary.wiley.com/doi/10.1111/mmi.12260/abstract