User:Jarle Pahr/Streptococcus

Pneumolysin is a cytolytic toxin, which together with cell wall fragments contributes to inflammatorh damage. ([1]) Malley et al. found that pneumolysin stimulates tumor necrosis factor-�and IL-6 release in macrophages, with the involvement of Toll-Like Receptors (TLRs) in pneumolysin recognition.

[1]: http://www.pnas.org/content/100/4/1966.full.pdf

Bibliography

http://www.ncbi.nlm.nih.gov/pubmed/21646297

http://iai.asm.org/content/69/6/3569.full

http://iai.asm.org/content/76/4/1547

http://iai.asm.org/content/73/10/6479.long

http://iai.asm.org/content/76/9/4079.full