User:Jarle Pahr/Synthetic biology

Notes on news and articles related to synthetic biology:

RNA-guided editing of bacterial genomes using CRISPR-Cas systems: http://www.nature.com/nbt/journal/v31/n3/full/nbt.2508.html

Amplifying genetic logic gates: http://www.sciencemag.org/content/early/2013/03/27/science.1232758.abstract

RNA processing enables predictable programming of gene expression: http://www.nature.com/nbt/journal/v30/n10/full/nbt.2355.html

Ribozyme-based insulator parts: http://www.nature.com/nbt/journal/v30/n11/full/nbt.2401.html?WT.ec_id=NBT-201211

Organizations and websites

http://syntheticbiology.org/

Concepts

Polymerases per second (POPS):

http://openwetware.org/wiki/PoPS

Bibliography

http://www.nature.com/nbt/journal/v27/n12/full/nbt1209-1109.html

Ideas

A biological PID? Input and the objective to be controlled could be levels of a protein or a metabolite. Output would be summed from the activity of three transcription units. Would need a way to create a set-point and convert the difference between the present level and the set-point to serve as input to the PID circuit.

• Proportional term. Activity is proportional to input (current level).
• Integrative term. Activity is proportional to the total input over a recent timeframe (how can this be achieved?)
• Derivative term. Activity is proportional to the change in input over a recent timeframe (how can this be achieved?)

Might be helpful to study mechanical or analog PID circuits.

Projects

http://www.kickstarter.com/projects/antonyevans/glowing-plants-natural-lighting-with-no-electricit