User:Jayanthi Jayakumar - Revision history

Jayanthi Jayakumar: /* Telephone # */

2010-08-22T22:47:04Z

Telephone #

←Older revision		Revision as of 22:47, 22 August 2010
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	2010		2010
	===Telephone #===		===Telephone #===
-	~~518-301-1834~~	+
	===Email===		===Email===
	jayanthi AT mit DOT edu		jayanthi AT mit DOT edu

Jayanthi Jayakumar: /* References */

2008-04-29T02:23:41Z

References

←Older revision		Revision as of 02:23, 29 April 2008
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	=== Predicted Outcomes ===		=== Predicted Outcomes ===
	===References ===		===References ===
-	Puceat, Michel. Pharmacological approaches to regenerative strategies for the treatment of cardiovascular diseases. ''Current Opinion in Pharmacology''(2008), '''8:''' 189-192.	+	Puceat, Michel. Pharmacological approaches to regenerative strategies for the treatment of cardiovascular diseases. ''Current Opinion in Pharmacology'' (2008), '''8:''' 189-192.

	Segers, Vincent F, and Lee, Richard T. Stem-cell therapy for cardiac disease. ''Nature'' (2008), '''451:''' 937-942.		Segers, Vincent F, and Lee, Richard T. Stem-cell therapy for cardiac disease. ''Nature'' (2008), '''451:''' 937-942.

Jayanthi Jayakumar: /* References */

2008-04-29T02:23:24Z

References

←Older revision		Revision as of 02:23, 29 April 2008
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	=== Predicted Outcomes ===		=== Predicted Outcomes ===
	===References ===		===References ===
-	Puceat, Michel. Pharmacological approaches to regenerative strategies for the treatment of cardiovascular diseases. ~~''Italic text~~''Current Opinion in Pharmacology~~''Italic text~~'' (2008), ~~'''Bold text~~'''8:~~'''Bold text~~'''189-192.	+	Puceat, Michel. Pharmacological approaches to regenerative strategies for the treatment of cardiovascular diseases. ''Current Opinion in Pharmacology''(2008), '''8:''' 189-192.

-	Segers, Vincent F, and Lee, Richard T. Stem-cell therapy for cardiac disease. ~~''Italic text~~''Nature~~''Italic text~~''(2008), ~~'''Bold text~~'''451:~~'''Bold text~~'''937-942.	+	Segers, Vincent F, and Lee, Richard T. Stem-cell therapy for cardiac disease. ''Nature'' (2008), '''451:''' 937-942.

-	Singh, Sanjay K, et al. REST maintains self-renewal and pluripotency of embryonic stem cells. ~~''Italic text~~''Nature~~''Italic text~~'' (2008), 1-7.	+	Singh, Sanjay K, et al. REST maintains self-renewal and pluripotency of embryonic stem cells. ''Nature'' (2008), 1-7.

	Tousoulis, Dimitris, et al. Heart regeneration: what cells to use and how? ''Current Opinion in Pharmacology'' (2008), '''8:''' 211-218.		Tousoulis, Dimitris, et al. Heart regeneration: what cells to use and how? ''Current Opinion in Pharmacology'' (2008), '''8:''' 211-218.

Jayanthi Jayakumar: /* References */

2008-04-29T02:21:51Z

References

←Older revision		Revision as of 02:21, 29 April 2008
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	Singh, Sanjay K, et al. REST maintains self-renewal and pluripotency of embryonic stem cells. ''Italic text''Nature''Italic text'' (2008), 1-7.		Singh, Sanjay K, et al. REST maintains self-renewal and pluripotency of embryonic stem cells. ''Italic text''Nature''Italic text'' (2008), 1-7.

-	Tousoulis, Dimitris, et al. Heart regeneration: what cells to use and how? ~~''Italic text~~''Current Opinion in Pharmacology~~''Italic text~~'' (2008), ~~'''Bold text~~'''8:~~'''Bold text~~''' 211-218.	+	Tousoulis, Dimitris, et al. Heart regeneration: what cells to use and how? ''Current Opinion in Pharmacology'' (2008), '''8:''' 211-218.

	== Research Interests ==		== Research Interests ==

Jayanthi Jayakumar: /* References */

2008-04-29T02:20:47Z

References

←Older revision		Revision as of 02:20, 29 April 2008
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	=== Details and Methods ===		=== Details and Methods ===
	=== Predicted Outcomes ===		=== Predicted Outcomes ===
-	===References ===	+	===References ===
		+	Puceat, Michel. Pharmacological approaches to regenerative strategies for the treatment of cardiovascular diseases. ''Italic text''Current Opinion in Pharmacology''Italic text'' (2008), '''Bold text'''8:'''Bold text'''189-192.

		+	Segers, Vincent F, and Lee, Richard T. Stem-cell therapy for cardiac disease. ''Italic text''Nature''Italic text''(2008), '''Bold text'''451:'''Bold text'''937-942.
		+
		+	Singh, Sanjay K, et al. REST maintains self-renewal and pluripotency of embryonic stem cells. ''Italic text''Nature''Italic text'' (2008), 1-7.
		+
		+	Tousoulis, Dimitris, et al. Heart regeneration: what cells to use and how? ''Italic text''Current Opinion in Pharmacology''Italic text'' (2008), '''Bold text'''8:'''Bold text''' 211-218.

	== Research Interests ==		== Research Interests ==

Jayanthi Jayakumar: /* Project Overview */

2008-04-29T02:15:21Z

Project Overview

←Older revision		Revision as of 02:15, 29 April 2008
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	=== Project Overview ===		=== Project Overview ===
-	==== Research problem ====	+	The goal of this project is to grow and sustain cardiac stem cells (CSCs) while maintaining their characteristics in vitro.
		+	The purpose of developing the CSCs is to eventually transplant them to the heart and induce their differentiation into the appropriate cardiac cell type. This will help to regenerate the damaged heart tissue.
		+	There are specific advantages to using CSCs. Since they are cells from the heart, they are compatible with the damaged heart tissue, leading to the increased likelihood of regeneration.
		+	=== Research problem ===
	(Predicted Problems)		(Predicted Problems)
	<blockquote>		<blockquote>

Jayanthi Jayakumar: /* Background Information */

2008-04-29T02:09:43Z

Background Information

←Older revision		Revision as of 02:09, 29 April 2008
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	=== Background Information ===		=== Background Information ===
	Cardiac diseases are one of the most common diseases in the world. This is especially problematic because heart failures are one the leading causes of death [2]. Chronic high blood pressure and heart attacks are widespread disorders that affect a wide range of people. These disorders cause irreparable damages to the heart tissue, eventually leading to heart failure. Unfortunately, the human heart does not have a mechanism to regenerate damaged heart tissues.		Cardiac diseases are one of the most common diseases in the world. This is especially problematic because heart failures are one the leading causes of death [2]. Chronic high blood pressure and heart attacks are widespread disorders that affect a wide range of people. These disorders cause irreparable damages to the heart tissue, eventually leading to heart failure. Unfortunately, the human heart does not have a mechanism to regenerate damaged heart tissues.
-	Researchers in the past have used embryonic stem cells, endothelial progenitor cells and mesenchymal stem cells to	+	Researchers in the past have used embryonic stem cells, endothelial progenitor cells and mesenchymal stem cells to try to regenerate these tissues. However, none of these seem to be as successful as expected.
		+	With the recent discovery of cardiac stem cells, the opportunity to induce regeneration of damaged heart tissue using the body's own cells is promising.

	=== Project Overview ===		=== Project Overview ===

Jayanthi Jayakumar: /* Background Information */

2008-04-29T02:06:30Z

Background Information

←Older revision		Revision as of 02:06, 29 April 2008
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	Growth of cardiac stem cells and the preservation of their characteristics in vitro.		Growth of cardiac stem cells and the preservation of their characteristics in vitro.
	=== Background Information ===		=== Background Information ===
		+	Cardiac diseases are one of the most common diseases in the world. This is especially problematic because heart failures are one the leading causes of death [2]. Chronic high blood pressure and heart attacks are widespread disorders that affect a wide range of people. These disorders cause irreparable damages to the heart tissue, eventually leading to heart failure. Unfortunately, the human heart does not have a mechanism to regenerate damaged heart tissues.
		+	Researchers in the past have used embryonic stem cells, endothelial progenitor cells and mesenchymal stem cells to
		+
	=== Project Overview ===		=== Project Overview ===
	==== Research problem ====		==== Research problem ====

Jayanthi Jayakumar: /* Research problem */

2008-04-29T02:01:04Z

Research problem

←Older revision		Revision as of 02:01, 29 April 2008
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	=== Project Overview ===		=== Project Overview ===
	==== Research problem ====		==== Research problem ====
-	~~<blockquote>~~
	(Predicted Problems)		(Predicted Problems)
		+	<blockquote>
	* Isolation of CSCs		* Isolation of CSCs
	* Optimization of growth conditions		* Optimization of growth conditions

Jayanthi Jayakumar: /* Research problem */

2008-04-29T02:00:44Z

Research problem

←Older revision		Revision as of 02:00, 29 April 2008
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	=== Project Overview ===		=== Project Overview ===
	==== Research problem ====		==== Research problem ====
		+	<blockquote>
	(Predicted Problems)		(Predicted Problems)
-	~ Isolation of CSCs	+	* Isolation of CSCs
-	~ Optimization of growth conditions	+	* Optimization of growth conditions
-	~ Transplation of CSCs in vivo	+	* Transplation of CSCs in vivo
		+	</blockquote>
		+
	=== Details and Methods ===		=== Details and Methods ===
	=== Predicted Outcomes ===		=== Predicted Outcomes ===